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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Astaxanthin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Astaxanthin

Osteoarthritis, Knee 2 PCOS 1 Ageing|Photo-aging 1 Risk factors of metabolic syndrome, type 2 diabetes mellitus 1 Painful Diabetic Neuropathy 1 Absorption; Chemicals 1 Hypertension (HTN) is the common modifiable risk factor for 1 Effect of astaxanthin supplementation on plasma metabolites, 1 Metabolic Syndrome X 1 Cognitive impairment, reported subjectively and/ or objectiv 1 Metabolic Flexibility 1 Astaxanthin, extracted from Haematococcus pluvialis (H. pluv 1

📋 Sample Trials

NCT02343497

Lipid-lowering Effects of an Astaxanthin Supplement in Volunteers With Mild Dyslipidaemia

Completed

NCT02397811

Astaxanthin Formulation Bioavailability

Completed

NCT03460860

Astaxanthin (2 mg) + Lycopene (1.8 mg) + D-Alpha-Tocopherol (10 IU) For The Treatment Of Skin Aging

Completed

📊 Sample Meta-Analyses

CRD42020215881

A systematic review of astaxanthin on the risk factors of metabolic syndrome

Risk factors of metabolic syndrome, type 2 diabetes mellitus

CRD42021275708

Impact of Astaxanthin supplementation on blood pressure: A systematic review and meta-analysis of randomized controlled trials

Hypertension (HTN) is the common modifiable risk factor for cardiovascular disea

CRD42022335796

Efficacy of astaxanthin in animal models of type 2 diabetes mellitus: a systematic review and meta-analysis

📚 Sample References

PMID 32003547

Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway

J Cachexia Sarcopenia Muscle · 2020

PMID 32082151

Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats

Front Pharmacol · 2020

PMID 32210012

Astaxanthin Prevents Mitochondrial Impairment Induced by Isoproterenol in Isolated Rat Heart Mitochondria

Antioxidants (Basel) · 2020

⚗️ All Ingredient data fields for Astaxanthin

⚗️ Identity

Name

Astaxanthin

Aliases / Synonyms

472-61-7; Ovoester; Astaxanthine; 3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione; all-trans-Astaxanthin; BioAstin; (3S,3'S)-Astaxanthin; AstaREAL; Natupink

🧪 Chemistry

Molecular Weight

596.8520

LogP

8.9054

Drug-likeness

0.247

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C

Isomeric SMILES

CC1=C(C(C[C@@H](C1=O)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C(=O)[C@H](CC2(C)C)O)C)\C)\C)/C)/C

InChIKey

MQZIGYBFDRPAKN-UWFIBFSHSA-N

InChI

InChI=1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1

🔗 External References

HERB DB

HBIN017178 ↗

PubChem CID

5281224 ↗

DrugBank

DB06543 ↗

NPASS

NPC74086

HIT

C0503

TCMID

1921

TCM-ID

10135

🔍 Raw view — every non-empty column on this row (31 fields)

name

Astaxanthin

common names

472-61-7; Ovoester; Astaxanthine; 3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione; all-trans-Astaxanthin; BioAstin; (3S,3'S)-Astaxanthin; AstaREAL; Natupink

herb ingredient id

HBIN017178

canonical smiles

CC1=C(C(CC(C1=O)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(C(=O)C(CC2(C)C)O)C)C)C

isomeric smiles

CC1=C(C(C[C@@H](C1=O)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C(=O)[C@H](CC2(C)C)O)C)\C)\C)/C)/C

inchi

inchikey

MQZIGYBFDRPAKN-UWFIBFSHSA-N

mol wt

596.8520

num h acceptors

num h donors

mol logp

8.9054

num rotatable bonds

drug likeness

0.247

tcmid ingredient id

1921

tcm id ingredient id

10135

pubchem cid

5281224

drugbank id

DB06543

npass id

NPC74086

hit id

C0503

🏥 Linked Health Topics

4 · studied for these conditions (text bridge)

📋 Clinical Trials

12 · subject of clinical study

NCT02343497 Lipid-lowering Effects of an Astaxanthin Supplement in Volunteers With Mild Dysl

→ Dyslipidemias

NCT02397811 Astaxanthin Formulation Bioavailability

→ Bioavailability of Astaxanthin Formulations

NCT03460860 Astaxanthin (2 mg) + Lycopene (1.8 mg) + D-Alpha-Tocopherol (10 IU) For The Trea

→ Skin Aging|Wrinkles

NCT03664466 Astaxanthin Effects on Osteoarthritis Associated Pain and Inflammatory Indicator

→ Osteoarthritis, Knee

NCT03991286 The Effect of Astaxanthin on Oxidative Stress Indices in Patients With Polycysti

→ PCOS

NCT04689984 The Benefits of Astaxanthin as Add on Therapy in the Management of Painful Diabe

→ Painful Diabetic Neuropathy

NCT05015374 Effect of Astaxanthin on the Patients With Alzheimer Disease

→ To Evaluate the Possible Benefit of Astaxanthin on

NCT05282355 Astaxanthin Reduces Exercising Heart Rate.

→ Metabolic Flexibility

NCT02310087 Oral Astaxanthin and Semen Quality, Fertilization and Embryo Development in Assi

→ Infertility, Male

NCT02373111 Effects of Isoflavone Combined With Astaxanthin on Skin Aging

→ Ageing|Photo-aging

NCT03310359 Clinical Trial of Anti-oxidant Astaxanthin in Insulin-resistant Subjects

→ Metabolic Syndrome X

NCT03368872 Clinical Trial of Astaxanthin Formulation With Exercise in Sarcopenia Elderly

→ Sarcopenia

📊 Meta-Analyses

9 · systematic review

CRD42020215881 A systematic review of astaxanthin on the risk factors of metabolic syndrome

→ Risk factors of metabolic syndrome, type 2 diabete

CRD42021275708 Impact of Astaxanthin supplementation on blood pressure: A systematic review and

→ Hypertension (HTN) is the common modifiable risk f

CRD42022335796 Efficacy of astaxanthin in animal models of type 2 diabetes mellitus: a systemat

CRD42022356955 Efficacy of astaxanthin supplementary on subjective fatigue, exercise performanc

→ Astaxanthin, extracted from Haematococcus pluviali

CRD42023428043 The effects of astaxanthin supplementation on liver enzymes levels: A systematic

→ Astaxanthin belongs to a group of carotenoids that

CRD42023409269 The effect of Astaxanthin intake on cardio-metabolic risk factors, Inflammatory,

→ unhealthy adults with metabolic syndrome and relat

CRD42023411548 Effects of Astaxanthin on Pathology-Related Biomarkers in Middle-Aged and Elderl

→ The rise in global life expectancy in recent decad

CRD42023437319 Effect of astaxanthin supplementation on plasma metabolites, inflammation, oxida

→ Effect of astaxanthin supplementation on plasma me

CRD42023470793 Astaxanthin and Improvement of Dementia: A Systematic Review of Current Clinical

→ Cognitive impairment, reported subjectively and/ o

📚 PubMed References

12 · cited research

PMID 32003547 Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via

J Cachexia Sarcopenia Muscle

PMID 32082151 Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors i

Front Pharmacol

PMID 32210012 Astaxanthin Prevents Mitochondrial Impairment Induced by Isoproterenol in Isolat

Antioxidants (Basel)

PMID 32351673 Astaxanthin Attenuates Hypertensive Vascular Remodeling by Protecting Vascular S

Oxid Med Cell Longev

PMID 32405635 Astaxanthin from Haematococcus pluvialis ameliorates the chemotherapeutic drug (

Food Funct

PMID 32438569 Astaxanthin Modulates Apoptotic Molecules to Induce Death of SKBR3 Breast Cancer

Mar Drugs

PMID 32446270 Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoh

Br J Pharmacol

PMID 32535081 Astaxanthin inhibits the reduction of glycolysis during the activation of hepati

Life Sci

PMID 32545395 Effect of Astaxanthin on Activation of Autophagy and Inhibition of Apoptosis in

Nutrients

PMID 32567157 Neuroprotective effects of astaxanthin against oxygen and glucose deprivation da

J Cell Mol Med

PMID 32604880 Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calc

Mar Drugs

PMID 32673631 Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxici

Food Chem Toxicol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables