Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Atropine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Atropine

Myopia 20 Amblyopia 4 Myopia, Progressive 3 Hypertrophic pyloric stenosis (HPS) is a condition character 1 Conscious Sedation 1 Myopia, also known as short-sightedness, is a refractive err 1 Progressive Myopia 1 Anesthesia 1 Myopia is a relatively prevalent and increasing public healt 1 Myopia|Children 1 The progression of myopia 1 Excessive salivation or drooling or Sialorrhea. 1

📋 Sample Trials

NCT00094614

Trial Comparing Daily Atropine Versus Weekend Atropine

Completed · Phase 4

NCT00251602

Analysis of Atropine and Propranolol Induced Changes

Completed · Phase 1

NCT00315302

Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye for Amblyopia in Children 3 to <7 Years Old

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42015017003

Atropine therapy versus no atropine therapy for the prevention of adverse events in paediatric patients undergoing intubation [Cochrane Protocol]

The Cochrane Anaesthesia Group

CRD42016051418

Atropine treatment for hypertrophic pyloric stenosis: a systematic review and meta-analysis

Hypertrophic pyloric stenosis (HPS) is a condition characterized by hypertrophy

CRD42019126789

The effectiveness of atropine for the treatment of excessive salivation

Excessive salivation or drooling or Sialorrhea.

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Atropine

⚗️ Identity

Name

Atropine

Aliases / Synonyms

dl-Hyoscyamine; 51-55-8; Tropine tropate; Atropen; Atropin; dl-Tropyltropate; Atropinol; Eyesules; Isopto-atropine

🧪 Chemistry

Molecular Weight

289.3750

LogP

1.9309

Drug-likeness

0.861

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3

Isomeric SMILES

CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3

InChIKey

RKUNBYITZUJHSG-PJPHBNEVSA-N

InChI

InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

NPASS

NPC209773

HIT

C1133

TCMID

2001

TCMSP

MOL002219; MOL005406; MOL009650

TCM-ID

6479

🔍 Raw view — every non-empty column on this row (33 fields)

name

Atropine

common names

dl-Hyoscyamine; 51-55-8; Tropine tropate; Atropen; Atropin; dl-Tropyltropate; Atropinol; Eyesules; Isopto-atropine

herb ingredient id

HBIN017334

canonical smiles

CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3

isomeric smiles

CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3

inchi

InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?

inchikey

RKUNBYITZUJHSG-PJPHBNEVSA-N

mol wt

289.3750

num h acceptors

num h donors

mol logp

1.9309

num rotatable bonds

drug likeness

0.861

cas id

51-55-8

tcmid ingredient id

2001

tcmsp ingredient id

MOL002219; MOL005406; MOL009650

tcm id ingredient id

6479

pubchem cid

174174

drugbank id

DB00572

npass id

NPC209773

hit id

C1133

🏥 Linked Health Topics

9 · studied for these conditions (text bridge)

Organophosphorus Poisoning

📋 Clinical Trials

12 · subject of clinical study

NCT00094614 Trial Comparing Daily Atropine Versus Weekend Atropine

→ Amblyopia

NCT00251602 Analysis of Atropine and Propranolol Induced Changes

→ Healthy

NCT00315302 Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye for Amb

→ Amblyopia

NCT00315328 Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds

→ Amblyopia

NCT00575523 Atropine for Prevention of Dysrhythmias Caused by Percutaneous Ethanol Instillat

→ Arrhythmia|Respiratory Arrest

NCT00623207 Use of Atropine in Tredmill Stress Testing

→ Chest Pain

NCT00815048 Remifentanil and Atropine for Intubation in Neonates

→ Endotracheal Intubation

NCT00834470 Adjunctive Atropine During Ketamine Sedation

→ Conscious Sedation

NCT00921102 Atropine to Prevent Nausea and Vomiting After Spinal Anesthesia for Caesarean Se

→ Cesarean Section|Anesthesia,Spinal|Postoperative N

NCT00944710 Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old

→ Amblyopia

NCT01191398 Effectiveness of Atropine and Glycopyrrolate to Reduce Hyper Salivation With Ket

→ Sialorrhea

NCT01819064 Heart Rate Response to Atropine Doses Less Than 0.1mg IV to Anesthetized Infants

→ Bradycardia|Arrhythmias

📊 Meta-Analyses

12 · systematic review

CRD42015017003 Atropine therapy versus no atropine therapy for the prevention of adverse events

→ The Cochrane Anaesthesia Group

CRD42016051418 Atropine treatment for hypertrophic pyloric stenosis: a systematic review and me

→ Hypertrophic pyloric stenosis (HPS) is a condition

CRD42019126789 The effectiveness of atropine for the treatment of excessive salivation

→ Excessive salivation or drooling or Sialorrhea.

CRD42019131332 Effectiveness of intravenous atropine prophylaxis for prevention of spinal anest

→ Hypotension is a common side effect of spinal anes

CRD42020182557 Effectiveness and safety of combined atropine 0.01% ophthalmic solution with Ort

→ teenager with myopia

CRD42020184301 Combined Orthokeratology with Atropine for children with Myopia: A Meta-analysis

→ Myopia has become a worldwide public health issue,

CRD42020188227 efficiency of atropine, contact lens and outdoors time spending on myopia progre

→ Myopia is an epidemic disease which has been a ser

CRD42020205924 Analysis of the influence of atropine eye drops in children's myopia: a syst

→ Myopia is a incresing ocular disease with range of

CRD42020207457 Efficiency of orthokeratology combined with 0.01% atropine to delay the progress

→ Myopia in children and adolescents

CRD42020220442 Atropine eye drops to control the progression of myopia: a systematic review and

→ Myopia has become a worldwide public health issue,

CRD42020220956 Effectiveness of orthokeratology combined with 0.01% atropine for Myopia in Asia

→ Childhood myopia has become a serious public conce

CRD42021247893 Efficacy and safety of atropine for the treatment of myopia: A meta-analysis of

→ Myopia is the most common cause of ocular disorder

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables