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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Azelaic acid

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Azelaic acid

Rosacea 7 Papulopustular Rosacea 7 Skin Manifestations 2 Healthy 2 Acne Vulgaris 1 Seborrheic Dermatitis on the Face 1 Acne Rosacea 1 Rosacea, Papulopustular 1 Perioral Dermatitis 1 Papulopustular Rosacea (PPR) 1 The Cochrane Skin Group 1 Melasma 1

📋 Sample Trials

NCT00403949

A Study of Azelaic Acid (AzA) 15% in Topical Treatment of Mild to Moderate Perioral Dermatitis

Completed · Phase 2

NCT00408330

A Study of Azelaic Acid (AzA) 15% Gel in the Treatment of Seborrheic Dermatitis of the Face

Completed · Phase 2

NCT01025635

Safety and Efficacy of Azelaic Acid Foam, 15% in Papulopustular Rosacea

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42015020787

Topical azelaic acid, salicylic acid, nicotinamide, and sulphur for acne [Cochrane Protocol]

The Cochrane Skin Group

CRD42020220648

The effectiveness of topical azelaic acid for dermatological conditions and cosmetic skin care

Skin conditions: anti-ageing and the dermatological conditions of rosacea, melas

CRD42022355230

The efficacy, safety and tolerability of topical minocycline compared with metronidazole, ivermectin, azelaic acid in moderate-to-severe papulopustular rosacea: a systematic review and meta‐analysis

Papulopustular facial rosacea

📚 Sample References

PMID 33425206

Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regulating the Prdxs/ROS Signaling Pathway

Oxid Med Cell Longev · 2020

⚗️ All Ingredient data fields for Azelaic acid

⚗️ Identity

Name

Azelaic acid

Aliases / Synonyms

NONANEDIOIC ACID; 123-99-9; Finacea; Anchoic acid; Azelex; Lepargylic acid; 1,7-Heptanedicarboxylic acid; Skinoren; 1,9-Nonanedioic acid

🧪 Chemistry

Molecular Weight

188.2230

LogP

1.8863

Drug-likeness

0.57

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(CCCC(=O)O)CCCC(=O)O

Isomeric SMILES

C(CCCC(=O)O)CCCC(=O)O

InChIKey

BDJRBEYXGGNYIS-UHFFFAOYSA-N

InChI

InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

🔗 External References

HERB DB

HBIN017449 ↗

PubChem CID

2266 ↗

DrugBank

DB00548 ↗

NPASS

NPC214608

TCMID

24407; 2056

TCM-ID

6449

🔍 Raw view — every non-empty column on this row (30 fields)

name

Azelaic acid

common names

NONANEDIOIC ACID; 123-99-9; Finacea; Anchoic acid; Azelex; Lepargylic acid; 1,7-Heptanedicarboxylic acid; Skinoren; 1,9-Nonanedioic acid

herb ingredient id

HBIN017449

canonical smiles

C(CCCC(=O)O)CCCC(=O)O

isomeric smiles

C(CCCC(=O)O)CCCC(=O)O

inchi

InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

inchikey

BDJRBEYXGGNYIS-UHFFFAOYSA-N

mol wt

188.2230

num h acceptors

num h donors

mol logp

1.8863

num rotatable bonds

drug likeness

0.57

tcmid ingredient id

24407; 2056

tcm id ingredient id

6449

pubchem cid

2266

drugbank id

DB00548

npass id

NPC214608

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

Papulopustular Rosacea

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00403949 A Study of Azelaic Acid (AzA) 15% in Topical Treatment of Mild to Moderate Perio

→ Perioral Dermatitis

NCT00408330 A Study of Azelaic Acid (AzA) 15% Gel in the Treatment of Seborrheic Dermatitis

→ Seborrheic Dermatitis on the Face

NCT01025635 Safety and Efficacy of Azelaic Acid Foam, 15% in Papulopustular Rosacea

→ Papulopustular Rosacea

NCT01257919 Safety and Pharmacokinetics of Azelaic Acid Foam, 15% in Papulopustular Rosacea

→ Papulopustular Rosacea

NCT01555463 Safety and Efficacy of Azelaic Acid Foam, 15 % in Papulopustular Rosacea

→ Papulopustular Rosacea

NCT02058628 Comparison of the Efficacy and Safety of Clindamycin + Benzoyl Peroxide Formulat

→ Acne Vulgaris

NCT03035955 Azelaic Acid on Demodex Counts in Rosacea

→ Rosacea

NCT03094403 To Evaluate the Therapeutic Equivalence and Safety of Azelaic Acid 15% Topical G

→ Rosacea

NCT05014906 Efficacy of Oral Minocycline (Solodyn) and Oral Minocycline (Solodyn) Plus Azela

→ Rosacea

NCT00417937 A Multicenter Trial of a Topical Medication for Papulopustular Rosacea Applied T

→ Papulopustular Rosacea

NCT00617903 Exploration of Safety and Efficacy of AzA 15% Foam Twice a Day in Rosacea

→ Papulopustular Rosacea

NCT00855595 Efficacy of Topical Azelaic Acid 15% Gel Plus Anti-inflammatory Dose Doxycycline

→ Papulopustular Rosacea

📊 Meta-Analyses

4 · systematic review

CRD42015020787 Topical azelaic acid, salicylic acid, nicotinamide, and sulphur for acne [Cochra

→ The Cochrane Skin Group

CRD42020220648 The effectiveness of topical azelaic acid for dermatological conditions and cosm

→ Skin conditions: anti-ageing and the dermatologica

CRD42022355230 The efficacy, safety and tolerability of topical minocycline compared with metro

→ Papulopustular facial rosacea

CRD42023433925 Azelaic Acid versus Hydroquinone for Managing Patients with Melasma

→ Patients with Melasma (pigmented skin disorder)

📚 PubMed References

1 · cited research

PMID 33425206 Azelaic Acid Exerts Antileukemia Effects against Acute Myeloid Leukemia by Regul

Oxid Med Cell Longev

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables