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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Berberime

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Berberime

Gastritis|Peptic Ulcer|Dyspepsia 2 Diabetes Mellitus 2 Type 2 diabetes.Chronic metabolic diseases. 1 Diabetic nephropathy (DN), or diabetic kidney disease (DKD), 1 Glycemia 1 Over the past decades, the efficacy and safety of berberine 1 Type 2 Diabetes 1 Cardiovascular Risk Factor 1 Helicobacter pylori (Hp) ：Isolated from patients with chroni 1 Nonalcoholic Fatty Liver Disease 1 Type 2 diabetes mellitus (T2DM) is one of the most common ch 1 Chronic Steatosis disease is a common cause of liver-related 1

📋 Sample Trials

NCT00425009

Therapeutic Effects of Berberine in Patients With Type 2 Diabetes

Completed · Phase 1|Phase 2

NCT00462046

Efficacy and Safety of Berberine in the Treatment of Diabetes With Dyslipidemia

Completed · Phase 3

NCT00633282

Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42011001335

Efficacy and safety of adding berberine to oral hypoglycaemia agents in lowering blood glucose among adults with type 2 diabetes mellitus: a systematic review

The prevalence of diabetes mellitus in the USA and China indicates that it has b

CRD42016044031

Berberine for polycystic ovary syndrome: a systematic review and meta-analysis of randomization controlled trials

Polycystic ovary syndrome. Berberine for Polycystic ovary syndrome.

CRD42018088497

Effectiveness of berberine for patients with acute coronary syndrome

Berberine Berberine for patients with acute coronary syndrome

📚 Sample References

PMID 34826601

The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition

Pharmacol Res · 2021

PMID 34890544

Berberine inhibits pancreatic intraepithelial neoplasia by inhibiting glycolysis via the adenosine monophosphate -activated protein kinase pathway

Eur J Pharmacol · 2021

PMID 34923903

Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study

Gut Microbes · 2021

⚗️ All Ingredient data fields for Berberime

⚗️ Identity

Name

Berberime

Aliases / Synonyms

berberine; 2086-83-1; Umbellatine; Berberin; Berbericine; Majarine; Thalsine; Umbellatin; Berberone; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium

🧪 Chemistry

Molecular Weight

336.3670

LogP

3.0963

Drug-likeness

0.674

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC

Isomeric SMILES

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC

InChIKey

YBHILYKTIRIUTE-UHFFFAOYSA-N

InChI

InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1

🔗 External References

HERB DB

HBIN017892 ↗

PubChem CID

2353 ↗

NPASS

NPC53069

HIT

C1171

TCMID

24513

🔍 Raw view — every non-empty column on this row (29 fields)

name

Berberime

common names

berberine; 2086-83-1; Umbellatine; Berberin; Berbericine; Majarine; Thalsine; Umbellatin; Berberone; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium

herb ingredient id

HBIN017892

canonical smiles

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC

isomeric smiles

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC

inchi

InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1

inchikey

YBHILYKTIRIUTE-UHFFFAOYSA-N

mol wt

336.3670

num h acceptors

num h donors

mol logp

3.0963

num rotatable bonds

drug likeness

0.674

tcmid ingredient id

24513

pubchem cid

2353

npass id

NPC53069

hit id

C1171

🏥 Linked Health Topics

7 · studied for these conditions (text bridge)

Polycystic Ovary Syndrome

syndrome

Schizophrenia

disease

Non-Alcoholic Fatty Liver Disease

syndrome

Glucose Metabolism Disorders

group

📋 Clinical Trials

12 · subject of clinical study

NCT00425009 Therapeutic Effects of Berberine in Patients With Type 2 Diabetes

→ Type 2 Diabetes

NCT00462046 Efficacy and Safety of Berberine in the Treatment of Diabetes With Dyslipidemia

→ Diabetes Mellitus, Type 2|Metabolic Syndrome

NCT00633282 Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Dis

→ Nonalcoholic Fatty Liver Disease

NCT02078167 Long Term Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Ri

→ Hypercholesterolemia

NCT02296021 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-

→ Gastritis|Peptic Ulcer|Dyspepsia

NCT02633930 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithr

→ Gastritis|Peptic Ulcer|Dyspepsia

NCT02808351 Berberine Prevent Contrast-induced Nephropathy in Patients With Diabetes

→ Diabetes Mellitus|Chronic Kidney Disease

NCT02936414 Berberine Effect on Cytokine, CRP, Metabolic Disturbance as an Adjunctive Therap

→ Schizophrenia

NCT02983188 Berberine as Adjuvant Treatment for Schizophrenia Patients

→ Schizophrenia|Schizophrenia Spectrum and Other Psy

NCT03029390 Effect of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity an

→ Prediabetes|Impaired Fasting Glucose|Impaired Gluc

NCT03198572 Efficacy and Safety of Berberine in Non-alcoholic Steatohepatitis

→ Non-alcoholic Steatohepatitis

NCT03251716 Berberine Treat Metabolic Syndrome in Schizophrenia

→ Metabolic Syndrome|Female|Schizophrenia

📊 Meta-Analyses

12 · systematic review

CRD42011001335 Efficacy and safety of adding berberine to oral hypoglycaemia agents in lowering

→ The prevalence of diabetes mellitus in the USA and

CRD42016044031 Berberine for polycystic ovary syndrome: a systematic review and meta-analysis o

→ Polycystic ovary syndrome. Berberine for Polycysti

CRD42018088497 Effectiveness of berberine for patients with acute coronary syndrome

→ Berberine Berberine for patients with acute coron

CRD42018094421 The efficacy and safety of berberine for dyslipidaemias: a systematic review and

→ Dyslipidaemias, characterized by increased plasma

CRD42019123225 Efficacy and safety of berberine in the treatment of type 2 diabetes with insuli

→ There are many patients with type 2 diabetes and i

CRD42019142286 Effect of berberine for experimental chemical and drug induced liver injury: a s

CRD42020151001 Berberine for diarrhea: a systematic review and meta-analysis

→ Diarrhea is defined as the passage of three or mor

CRD42020155086 Evidence and Potential Mechanisms of Berberine or Coptis chinensis -containing T

→ According to International Diabetes Federatio Diab

CRD42020171175 Effect of berberine for type 2 diabetes mellitus (T2DM): a preclinical systemati

CRD42020177528 Berberine and diabetic nephropathy：a systematic review and meta-analysis

→ Produced by several different medicinal plants, be

CRD42020184592 efficiency and safety of berberine therapy in patients with non-alcoholic fatty

→ Efficacy of berberine against non-alcoholic fatty

CRD42020209135 The efficacy and safety of berberine in the recurrence of colorectal adenomas: a

→ 85-90% of colorectal cancers develop from colorect

📚 PubMed References

12 · cited research

PMID 34826601 The natural product berberine synergizes with osimertinib preferentially against

Pharmacol Res

PMID 34890544 Berberine inhibits pancreatic intraepithelial neoplasia by inhibiting glycolysis

Eur J Pharmacol

PMID 34923903 Combined berberine and probiotic treatment as an effective regimen for improving

Gut Microbes

PMID 34968467 Berberine inhibits gastric cancer development and progression by regulating the

Life Sci

PMID 34984827 Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppr

J Cell Mol Med

PMID 35001506 Berberine regulates mesangial cell proliferation and cell cycle to attenuate dia

J Cell Mol Med

PMID 35037116 Improvement of adjunctive berberine treatment on negative symptoms in patients w

Eur Arch Psychiatry Clin Neurosci

PMID 35093536 Novel mechanistic insight on the neuroprotective effect of berberine: The role o

Free Radic Biol Med

PMID 35173608 Berberine Inhibits FOXM1 Dependent Transcriptional Regulation of POLE2 and Inter

Front Pharmacol

PMID 35215376 Pre-Administration of Berberine Exerts Chemopreventive Effects in AOM/DSS-Induce

Nutrients

PMID 35250593 Combined Use of Bicyclol and Berberine Alleviates Mouse Nonalcoholic Fatty Liver

Front Pharmacol

PMID 35259053 Berberine represses Wnt/β-catenin pathway activation via modulating the microRNA

Bioengineered

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables