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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Berberine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Berberine

Pharmacokinetic Study in Healthy Volunteers 1 Diabetes Mellitus 1

📋 Sample Trials

NCT05845931

Sex Differences in Berberine Pharmacokinetics

Recruiting

NCT05947370

Berberine on the Secretion of Incretin

Completed · Early_Phase 1

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 31037132

Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction

Theranostics · 2019

PMID 28990249

Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer

Cell Prolif · 2017

PMID 25682924

Berberine inhibits the proliferation of human uterine leiomyoma cells

Fertil Steril · 2015

⚗️ All Ingredient data fields for Berberine

⚗️ Identity

Name

Berberine

Aliases / Synonyms

2086-83-1; Umbellatine; Berberin; Berbericine; Majarine; Thalsine; Umbellatin; Berberone; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium

🧪 Chemistry

Molecular Weight

336.3670

LogP

3.0963

Drug-likeness

0.674

Oral Bioavailability

36.8610

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC

Isomeric SMILES

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC

InChIKey

YBHILYKTIRIUTE-UHFFFAOYSA-N

InChI

InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

NPASS

NPC183485

SymMap

104

TCMID

2303

TCMSP

MOL001454

TCM-ID

6346

🔍 Raw view — every non-empty column on this row (34 fields)

name

Berberine

common names

2086-83-1; Umbellatine; Berberin; Berbericine; Majarine; Thalsine; Umbellatin; Berberone; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium

herb ingredient id

HBIN017893

canonical smiles

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC

isomeric smiles

COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC

inchi

InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1

inchikey

YBHILYKTIRIUTE-UHFFFAOYSA-N

mol wt

336.3670

num h acceptors

num h donors

mol logp

3.0963

num rotatable bonds

drug likeness

0.674

ob score

36.8610

cas id

2086-83-1

symmap mol id

104

tcmid ingredient id

2303

tcmsp ingredient id

MOL001454

tcm id ingredient id

6346

pubchem cid

2353

drugbank id

DB04115

npass id

NPC183485

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Diabetes Mellitus

group

📋 Clinical Trials

2 · subject of clinical study

NCT05845931 Sex Differences in Berberine Pharmacokinetics

→ Pharmacokinetic Study in Healthy Volunteers

NCT05947370 Berberine on the Secretion of Incretin

→ Diabetes Mellitus

📚 PubMed References

12 · cited research

PMID 31037132 Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondri

Theranostics

PMID 28990249 Berberine inhibits the chemotherapy-induced repopulation by suppressing the arac

Cell Prolif

PMID 25682924 Berberine inhibits the proliferation of human uterine leiomyoma cells

Fertil Steril

PMID 22019891 A clinical study on the short-term effect of berberine in comparison to metformi

Eur J Endocrinol

PMID 21496227 Berberine modulates AP-1 activity to suppress HPV transcription and downstream s

Mol Cancer

PMID 31399854 Berberine inhibits epithelial-mesenchymal transition and promotes apoptosis of t

J Cell Commun Signal

PMID 31734944 Berberine protects against diabetic kidney disease via promoting PGC-1α-regulate

Br J Pharmacol

PMID 31828466 Berberine attenuated the cytotoxicity induced by t-BHP via inhibiting oxidative

Cell Mol Neurobiol

PMID 31866303 Circadian pharmacological effects of berberine on chronic colitis in mice: Role

Biochem Pharmacol

PMID 31874145 Berberine suppresses colon cancer cell proliferation by inhibiting the SCAP/SREB

Biochem Pharmacol

PMID 31881227 MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of be

Life Sci

PMID 31976031 Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in

Oxid Med Cell Longev

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables