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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Biotin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Biotin

Diabetes Mellitus, Type 2 2 Biotinidase deficiency is an autosomal recessively inherited 1 Biotin Deficiency 1 Thoracic Diseases|Parathyroid Diseases 1 Amyotrophic Lateral Sclerosis 1 Severe Obesity|Metabolic Syndrome 1 Progressive Multiple Sclerosis 1 Moderate Persistent Asthma 1 Healthy Volunteers|Biotin Excretion 1 Healthy 1 Hair Falling|Thin Hair|Dry Hair|Brittle Hair|Dry Skin 1 End Stage Renal Disease|Restless Legs Syndrome 1

📋 Sample Trials

NCT00894920

Biotin Status in Pregnancy

Completed

NCT03034707

Interference of Biotin Supplementation in Biotin-streptavidin Platforms for Hormone Testing

Completed

NCT03427086

Safety and Tolerability of High Dose Biotin in Patients With Amyotrophic Lateral Sclerosis

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42020182059

Effect of newborn screening and time to treatment on the clinical course of biotinidase deficiency: a systematic review.

Biotinidase deficiency is an autosomal recessively inherited disorder in which a

CRD42023487188

Post-Partum Hair Fall, Is There Any Solution? A Systematic Review

Post-partum hair fall, therapy.

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Biotin

⚗️ Identity

Name

Biotin

Aliases / Synonyms

d-biotin; 58-85-5; vitamin H; Vitamin B7; Bioepiderm; coenzyme R; Bios II; Factor S; D(+)-Biotin

🧪 Chemistry

Molecular Weight

244.3160

LogP

0.7968

Drug-likeness

0.493

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1C2C(C(S1)CCCCC(=O)O)NC(=O)N2

Isomeric SMILES

C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2

InChIKey

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

InChI

InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

🔗 External References

HERB DB

HBIN018535 ↗

PubChem CID

171548 ↗

DrugBank

DB00121 ↗

NPASS

NPC199072

HIT

C1189

SymMap

1298

TCMID

2395

TCM-ID

6199

🔍 Raw view — every non-empty column on this row (32 fields)

name

Biotin

common names

d-biotin; 58-85-5; vitamin H; Vitamin B7; Bioepiderm; coenzyme R; Bios II; Factor S; D(+)-Biotin

herb ingredient id

HBIN018535

canonical smiles

C1C2C(C(S1)CCCCC(=O)O)NC(=O)N2

isomeric smiles

C1[C@H]2[C@@H]([C@@H](S1)CCCCC(=O)O)NC(=O)N2

inchi

InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

inchikey

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

mol wt

244.3160

num h acceptors

num h donors

mol logp

0.7968

num rotatable bonds

drug likeness

0.493

symmap mol id

1298

tcmid ingredient id

2395

tcm id ingredient id

6199

pubchem cid

171548

drugbank id

DB00121

npass id

NPC199072

hit id

C1189

🏥 Linked Health Topics

4 · studied for these conditions (text bridge)

Amyotrophic Lateral Sclerosis

syndrome

Biotin Deficiency

syndrome

Progressive Multiple Sclerosis

syndrome

Moderate Persistent Asthma

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00894920 Biotin Status in Pregnancy

→ Biotin Deficiency

NCT03034707 Interference of Biotin Supplementation in Biotin-streptavidin Platforms for Horm

→ Thoracic Diseases|Parathyroid Diseases

NCT03427086 Safety and Tolerability of High Dose Biotin in Patients With Amyotrophic Lateral

→ Amyotrophic Lateral Sclerosis

NCT03746821 Biotin Sample Collection Study

→ Healthy Volunteers|Biotin Excretion

NCT03995277 Effect of Biotin on Routine Laboratory Values

→ Biotin Ingestion|Interference With Routine Analyic

NCT00289354 Efficacy and Safety Study of Chromium Picolinate + Biotin on Glucose and Cholest

→ Diabetes Mellitus, Type 2

NCT00308451 A 30 Day Acute Efficacy and Safety Study of Chromium Picolinate + Biotin on Glyc

→ Diabetes Mellitus, Type 2

NCT02011191 Biotin Deficiency and Restless Legs Syndrome

→ End Stage Renal Disease|Restless Legs Syndrome

NCT03302806 Study to Assess Effect and Safety of High Dose of Biotin (Qizenday®) in Progress

→ Progressive Multiple Sclerosis

NCT05450900 Can Biotin Supplementation be Used to Mask hCG Abuse?

→ Healthy

NCT05632549 The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapi

→ Moderate Persistent Asthma

NCT05832190 Correcting GUT microbioTa by Combined Supplementation of fibERs and bIotiN to Im

→ Severe Obesity|Metabolic Syndrome

📊 Meta-Analyses

2 · systematic review

CRD42020182059 Effect of newborn screening and time to treatment on the clinical course of biot

→ Biotinidase deficiency is an autosomal recessively

CRD42023487188 Post-Partum Hair Fall, Is There Any Solution? A Systematic Review

→ Post-partum hair fall, therapy.

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables