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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

17-beta-estradiol

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with 17-beta-estradiol

Postmenopausal Vaginal Atrophy 1 Climacteric Syndrome|Menopause|Hypoestrogenism 1 Soy protein is a recommended protein source in dietary guide 1 Overweight 1 Bioequivalence 1 School bullying behavior or peer victimization 1 Overactive Bladder Syndrome 1 Pain includes experimental pain and clinical pain conditions 1 Osteoporosis Risk|Menopause 1 Oral contraceptives are used by many women around the world. 1 Metastatic Breast Cancer 1 Molecular and genetic expression in endometrial samples or c 1

📋 Sample Trials

NCT05197374

Effect of Estradiol Pretreatment on Antagonist ICSI Cycles

Completed · Phase 4

NCT05586711

Local DHEA and Estradiol on Dyspareunia in Postmenopausal Women

Recruiting · Phase 4

NCT05243823

Vaginal Estradiol Tablets (Vagifem®) and Endometrial Cancer Risk in the Treatment of Postmenopausal Vaginal Atrophy

Completed

📊 Sample Meta-Analyses

CRD42020187219

The effect of using of estradiol, progestogen, or contraceptive pill as pretreatment for GnRH antagonist cycles

We would like to the study the effect of using of estradiol, progestogen, or con

CRD42020204087

The efficacy of luteal estradiol pretreatment prior to the GnRH antagonist protocol in normal responders, a systemic review and meta-analysis.

GnRH antagonist protocol had gaining popularity recently, however, its numbers o

CRD42022368235

Serum estradiol and cardiovascular events in postmenopausal individuals: a systematic review and meta-analysis

Cardiovascular-related mortality, adverse cardiovascular events (i.e., myocardia

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for 17-beta-estradiol

⚗️ Identity

Name

17-beta-estradiol

Aliases / Synonyms

estradiol; beta-Estradiol; 17beta-Estradiol; 50-28-2; Oestradiol; Dihydrofolliculin; Estrace; Vivelle; progynon; Diogynets

🧪 Chemistry

Molecular Weight

272.3880

LogP

3.6092

Drug-likeness

0.757

Oral Bioavailability

12.4120

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O

InChIKey

VOXZDWNPVJITMN-ZBRFXRBCSA-N

InChI

InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

NPASS

NPC48342

HIT

C0055

SymMap

11883

TCMID

23197; 31749

TCMSP

MOL010919

TCM-ID

9262

🔍 Raw view — every non-empty column on this row (35 fields)

name

17-beta-estradiol

common names

estradiol; beta-Estradiol; 17beta-Estradiol; 50-28-2; Oestradiol; Dihydrofolliculin; Estrace; Vivelle; progynon; Diogynets

herb ingredient id

HBIN001991

canonical smiles

CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

isomeric smiles

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O

inchi

InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

inchikey

VOXZDWNPVJITMN-ZBRFXRBCSA-N

mol wt

272.3880

num h acceptors

num h donors

mol logp

3.6092

num rotatable bonds

drug likeness

0.757

ob score

12.4120

cas id

50-28-2

symmap mol id

11883

tcmid ingredient id

23197; 31749

tcmsp ingredient id

MOL010919

tcm id ingredient id

9262

pubchem cid

5757

drugbank id

DB00783

npass id

NPC48342

hit id

C0055

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

Female Infertility

phenotype

Recurrent Urinary Tract Infection

Overactive Bladder Syndrome

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT05197374 Effect of Estradiol Pretreatment on Antagonist ICSI Cycles

→ Female Infertility

NCT05586711 Local DHEA and Estradiol on Dyspareunia in Postmenopausal Women

→ Vulvovaginal Atrophy|Genitourinary Syndrome of Men

NCT05243823 Vaginal Estradiol Tablets (Vagifem®) and Endometrial Cancer Risk in the Treatmen

→ Postmenopausal Vaginal Atrophy

NCT05332106 Bioavailability of Estradiol Valerate and Dienogest 2 mg/2 mg With Regards to Re

→ Bioequivalence

NCT05221021 Vaginal Estradiol vs Oral Beta-3 Agonist for Overactive Bladder Syndrome

→ Overactive Bladder Syndrome

NCT05617820 Study Comparing Estradiol Vaginal Inserts 4mcg To IMVEXXY ® (Estradiol Vaginal I

→ Dyspareunia

NCT05282277 Examining the Effects of Estradiol on Neural and Molecular Response to Reward

→ Depression|Psychosis|Anhedonia

NCT05388656 Estrogen Variability and Irritability During the Menopause Transition

→ Menopause|Irritable Mood

NCT05903820 Rhythmic Estradiol and Bone Health

→ Osteoporosis Risk|Menopause

NCT06005610 Estradiol Therapy In Transgender Women to Research Interactions With HIV Therapy

→ HIV I Infection

NCT06136208 Pharmacokinetic Aspects of 25-mg Estradiol Pellet in Climacteric Women

→ Climacteric Syndrome|Menopause|Hypoestrogenism

NCT05716516 STUDY02001740;22SCH740: Estradiol For ER+ Advanced Breast Cancer (ESTHER)

→ Metastatic Breast Cancer

📊 Meta-Analyses

9 · systematic review

CRD42020187219 The effect of using of estradiol, progestogen, or contraceptive pill as pretreat

→ We would like to the study the effect of using of

CRD42020204087 The efficacy of luteal estradiol pretreatment prior to the GnRH antagonist proto

→ GnRH antagonist protocol had gaining popularity re

CRD42022368235 Serum estradiol and cardiovascular events in postmenopausal individuals: a syste

→ Cardiovascular-related mortality, adverse cardiova

CRD42023429752 Molecular and genetic regulation of the healthy endometrium by estrogens and pro

→ Molecular and genetic expression in endometrial sa

CRD42023439239 The effect of soy isoflavones on estrogen-related intermediate outcomes: A syste

→ Soy protein is a recommended protein source in die

CRD42023460827 Hormonal contraception and bone metabolism

→ Oral contraceptives are used by many women around

CRD42023494710 Sex Hormones and Pain: A Systematic Review and Meta-analysis.

→ Pain includes experimental pain and clinical pain

CRD42023494738 HPA and HPG dependent hormones and bullying behavior: a systematic review

→ School bullying behavior or peer victimization

CRD42023358439 Efficacy and Safety of Individualized versus Conventional Ovarian Stimulation fo

→ infertility couples treat with assisted reproducti

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables