Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Cannabidiol

Open on HERB 2.0 ↗

137

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Cannabidiol

Epilepsy 9 Schizophrenia 5 Healthy 4 Cannabis Use Disorder 3 Alcohol Use Disorder 3 Opioid-use Disorder 2 Opioid Use Disorder 2 Social Anxiety Disorder 2 Tuberous Sclerosis Complex|Seizures 2 Opiate Addiction 2 Schizophrenia|Schizoaffective Disorder 2 Infantile Spasms 2

📋 Sample Trials

NCT04851392

Do Adolescents and Adults Differ in Their Acute Response to Cannabis?

Completed

NCT00309413

A Clinical Trial on the Antipsychotic Properties of Cannabidiol

Completed · Phase 2

NCT00588731

Cannabidiol Treatment of Cognitive Dysfunction in Schizophrenia

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42018032359

Cannabidiol (CBD) in the treatment of infantile refractory epilepsy: systematic review with metanalysis

Refractory epilepsy in people up to 12 years old.

CRD42018080518

Neuroprotective role of cannabidiol: a systematic review

Neuroinflammation, neuroimmunology, brain tissue oxidative/nitrosative stress or

CRD42018090260

Systematic review of cannabidiol for psychotic disorders<br />

Psychotic disorders

📚 Sample References

PMID 31699976

Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

Cell Death Dis · 2019

PMID 31648363

A time-dependent contribution of hippocampal CB1 , CB2 and PPARγ receptors to cannabidiol-induced disruption of fear memory consolidation

Br J Pharmacol · 2019

PMID 31570536

Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1-2 Phosphorylation

J Neurosci · 2019

⚗️ All Ingredient data fields for Cannabidiol

⚗️ Identity

Name

Cannabidiol

Aliases / Synonyms

13956-29-1; (-)-Cannabidiol; (-)-trans-Cannabidiol; Epidiolex; CBD; (-)-CBD; GWP42003-P; CARDIOLRX; Cannabidiol [USAN]

🧪 Chemistry

Molecular Weight

314.4690

LogP

5.8465

Drug-likeness

0.511

Oral Bioavailability

3.9670

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CCCCCC1=CC(=C(C(=C1)O)C2C=C(CCC2C(=C)C)C)O

Isomeric SMILES

CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O

InChIKey

QHMBSVQNZZTUGM-ZWKOTPCHSA-N

InChI

InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1

🔗 External References

HERB DB

HBIN019558 ↗

PubChem CID

644019 ↗

CAS Number

13956-29-1 ↗

NPASS

NPC299568

HIT

C1211

SymMap

588

TCMID

3079

TCMSP

MOL005027

TCM-ID

5972

🔍 Raw view — every non-empty column on this row (34 fields)

name

Cannabidiol

common names

13956-29-1; (-)-Cannabidiol; (-)-trans-Cannabidiol; Epidiolex; CBD; (-)-CBD; GWP42003-P; CARDIOLRX; Cannabidiol [USAN]

herb ingredient id

HBIN019558

canonical smiles

CCCCCC1=CC(=C(C(=C1)O)C2C=C(CCC2C(=C)C)C)O

isomeric smiles

CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O

inchi

InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1

inchikey

QHMBSVQNZZTUGM-ZWKOTPCHSA-N

mol wt

314.4690

num h acceptors

num h donors

mol logp

5.8465

num rotatable bonds

drug likeness

0.511

ob score

3.9670

cas id

13956-29-1

symmap mol id

588

tcmid ingredient id

3079

tcmsp ingredient id

MOL005027

tcm id ingredient id

5972

pubchem cid

644019

npass id

NPC299568

hit id

C1211

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

📋 Clinical Trials

12 · subject of clinical study

NCT04851392 Do Adolescents and Adults Differ in Their Acute Response to Cannabis?

→ Cannabis|Cannabis Intoxication|Cannabis Use|Cannab

NCT00309413 A Clinical Trial on the Antipsychotic Properties of Cannabidiol

→ Schizophrenia|Psychotic Disorders

NCT00588731 Cannabidiol Treatment of Cognitive Dysfunction in Schizophrenia

→ Schizophrenia|Schizoaffective Disorder

NCT00628290 Evaluation of the Antipsychotic Efficacy of Cannabidiol in Acute Schizophrenic P

→ Schizophrenia

NCT01037322 Cannabidiol for Inflammatory Bowel Disease

→ Crohn's Disease|Ulcerative Colitis

NCT01180374 The Effects of Cannabidiol and ∆-9-THC in Humans

→ Healthy

NCT01311778 Study to Test the Safety and Efficacy of Cannabidiol as a Treatment Intervention

→ Opiate Addiction

NCT02044809 Cannabidiol: a Novel Intervention for Cannabis Use Problems?

→ Cannabis Use Disorder

NCT02051387 Cannabidiol as a Different Type of an Antipsychotic: Drug Delivery and Interacti

→ Schizophrenia

NCT02088060 A Four-week Clinical Trial Investigating Efficacy and Safety of Cannabidiol as a

→ Schizophrenia

NCT02286986 Cannabidiol (CBD) to 27 Patients (Aged 2 Years - 19 Years) With Drug Resistant E

→ Epilepsy

NCT02291536 Processing of Salient Emotional Stimuli as a Function of Tetrahydrocannabinol (T

→ Healthy Humans

📊 Meta-Analyses

12 · systematic review

CRD42018032359 Cannabidiol (CBD) in the treatment of infantile refractory epilepsy: systematic

→ Refractory epilepsy in people up to 12 years old.

CRD42018080518 Neuroprotective role of cannabidiol: a systematic review

→ Neuroinflammation, neuroimmunology, brain tissue o

CRD42018090260 Systematic review of cannabidiol for psychotic disorders<br />

→ Psychotic disorders

CRD42018105628 Cannabidiol and withdrawal treatment

→ cannabis and marijuana users, dependence and withd

CRD42018109578 Cannabidiol as a candidate alcohol use disorder pharmacotherapy: a systematic re

→ Alcohol use disorder, alcohol abuse or dependence.

CRD42018109957 Cannabidiol and emotional memory: a systematic review

→ Cannabidiol, emotional memory, psychiatric disorde

CRD42018111429 A meta-analysis of the safety, tolerability, and side effects of cannabidiol (CB

→ Cannabidiol (CBD) for all indications.

CRD42019119735 Efficacy and safety of cannabidiol in the treatment of tumors in humans: a syste

→ Tumors or tumours in/on humans from malignancy tha

CRD42019119766 Cannabidiol as a treatment for mood disorders: a systematic review

→ Mood disorders (Depressive disorders or Bipolar di

CRD42019124628 Efficacy and safety of cannabidiol in the treatment of conflict-related post-tra

→ Post-Traumatic Stress Disorders directly related t

CRD42019126994 How does cannabidiol (CBD) influence the acute effects of delta-9- tetrahydrocan

→ The acute administration of Δ9-THC and CBD in huma

CRD42019131354 Cannabidiol (CBD) for autism spectrum disorders: a systematic review

→ Autism spectrum disorders.

📚 PubMed References

12 · cited research

PMID 31699976 Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer

Cell Death Dis

PMID 31648363 A time-dependent contribution of hippocampal CB1 , CB2 and PPARγ receptors to ca

Br J Pharmacol

PMID 31570536 Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabino

J Neurosci

PMID 31518892 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1

Redox Biol

PMID 31382646 Cannabidiol Regulates the Expression of Keratinocyte Proteins Involved in the In

Cells

PMID 31326506 Cannabidiol improves behavioural and neurochemical deficits in adult female offs

Brain Behav Immun

PMID 31075907 Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Col

Cancers (Basel)

PMID 30660647 Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorec

Cancer Lett

PMID 30177808 Antiapoptotic effects of cannabidiol in an experimental model of cognitive decli

Transl Psychiatry

PMID 30157131 Cannabidiol modulates serotonergic transmission and reverses both allodynia and

Pain

PMID 30061636 GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour gr

Oncogene

PMID 29940353 Cannabidiol induced apoptosis in human monocytes through mitochondrial permeabil

Free Radic Biol Med

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables