Relationship Graph Explorer

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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Cantharidin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Cantharidin

Molluscum Contagiosum 4 Inflammation 2 Common Wart|Warts Hand|Warts|Papillomavirus Infections|DNA V 1 Arthritis, Rheumatoid 1 Verruca Vulgaris 1 Molluscum Contagiosum, Skin Disease 1

📋 Sample Trials

NCT00667225

Efficacy of Cantharidin in Molluscum Contagiosum

Completed

NCT01084824

A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen (LN2) and Cantharidin

Completed

NCT02665260

Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum Contagiosum

Completed · Phase 2

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 30478299

The combination of cantharidin and antiangiogenic therapeutics presents additive antitumor effects against pancreatic cancer

Oncogenesis · 2018

PMID 29797403

Serine/threonine protein phosphatase 5 is a potential therapeutic target in cholangiocarcinoma

Liver Int · 2018

PMID 24425774

Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors

Proc Natl Acad Sci U S A · 2014

⚗️ All Ingredient data fields for Cantharidin

⚗️ Identity

Name

Cantharidin

Aliases / Synonyms

56-25-7; Cantharone; CANTHARIDINE; Kantaridin; Kantharidin; Cantharides camphor; Cantaridina; Cantharidinum; Kantharidin [German]

🧪 Chemistry

Molecular Weight

196.2020

LogP

0.6436

Drug-likeness

0.421

Oral Bioavailability

51.2340

H-Bond Acceptors

🔬 Structures

Canonical SMILES

CC12C3CCC(C1(C(=O)OC2=O)C)O3

Isomeric SMILES

C[C@@]12[C@H]3CC[C@@H]([C@@]1(C(=O)OC2=O)C)O3

InChIKey

DHZBEENLJMYSHQ-XCVPVQRUSA-N

InChI

InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-

🔗 External References

HERB DB

HBIN019611 ↗

PubChem CID

5944 ↗

CAS Number

56-25-7 ↗

HIT

C0958

SymMap

4211

TCMID

3094

TCMSP

MOL001858

TCM-ID

5930

🔍 Raw view — every non-empty column on this row (33 fields)

name

Cantharidin

common names

56-25-7; Cantharone; CANTHARIDINE; Kantaridin; Kantharidin; Cantharides camphor; Cantaridina; Cantharidinum; Kantharidin [German]

herb ingredient id

HBIN019611

canonical smiles

CC12C3CCC(C1(C(=O)OC2=O)C)O3

isomeric smiles

C[C@@]12[C@H]3CC[C@@H]([C@@]1(C(=O)OC2=O)C)O3

inchi

InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-

inchikey

DHZBEENLJMYSHQ-XCVPVQRUSA-N

mol wt

196.2020

num h acceptors

num h donors

mol logp

0.6436

num rotatable bonds

drug likeness

0.421

ob score

51.2340

cas id

56-25-7

symmap mol id

4211

tcmid ingredient id

3094

tcmsp ingredient id

MOL001858

tcm id ingredient id

5930

pubchem cid

5944

hit id

C0958

🏥 Linked Health Topics

3 · diseases via target pathways

Inflammation

phenotype

Molluscum Contagiosum

syndrome

Arthritis, Rheumatoid

disease

📋 Clinical Trials

10 · subject of clinical study

NCT00667225 Efficacy of Cantharidin in Molluscum Contagiosum

→ Molluscum Contagiosum, Skin Disease

NCT01084824 A Trial Examining the Treatment of Common Warts With Combination Liquid Nitrogen

→ Verruca Vulgaris

NCT02665260 Safety and Efficacy Study of Topical Cantharidin for the Treatment of Molluscum

→ Molluscum Contagiosum

NCT03017846 Safety and Efficacy of Topical Cantharidin for the Treatment of Molluscum Contag

→ Molluscum Contagiosum

NCT03487549 Cantharidin and Occlusion in Verruca Epithelium

→ Common Wart|Warts Hand|Warts|Papillomavirus Infect

NCT01026064 Cantharidin-induced Skin Blister for Testing Anti-inflammatory Effects of Macrol

→ Inflammation

NCT01762787 Phase I Methodology Study to Validate the Cantharidin Blister Model in Healthy V

→ Inflammation

NCT03306589 Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM

→ Arthritis, Rheumatoid

NCT03377790 Cantharidin Application in Molluscum Patients-1

→ Molluscum Contagiosum

NCT03377803 Cantharidin Application in Molluscum Patients

→ Molluscum Contagiosum

📚 PubMed References

8 · cited research

PMID 30478299 The combination of cantharidin and antiangiogenic therapeutics presents additive

Oncogenesis

PMID 29797403 Serine/threonine protein phosphatase 5 is a potential therapeutic target in chol

Liver Int

PMID 24425774 Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-o

Proc Natl Acad Sci U S A

PMID 21958460 Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phospha

Eur J Cancer

PMID 21376459 PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through p

Cancer Lett

PMID 32407961 Cantharidin treatment inhibits hepatocellular carcinoma development by regulatin

Pharmacol Res

PMID 34326690 Cantharidin inhibits osteosarcoma proliferation and metastasis by directly targe

Int J Biol Sci

PMID 36499054 Inhibition of MZF1/c-MYC Axis by Cantharidin Impairs Cell Proliferation in Gliob

Int J Mol Sci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables