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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Capsaicin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Capsaicin

Pain 7 Healthy 7 Chest Pain 2 Osteoarthritis, Knee 2 Non-allergic Rhinitis 2 Supplementation of capsaicin and its derivatives may benefit 1 Post Surgical Neuropathic Pain 1 Knee osteoarthritis（KOA）is a common chronic degenerative dis 1 Neuropathic Pain|Chronic Pain 1 Acute Pain 1 Cannabinoid hyperemesis syndrome (CHS) is a condition that i 1 Head and Neck Cancer|Radiation Toxicity 1

📋 Sample Trials

NCT00003610

Capsaicin Lozenges in Treating Patients With Mucositis Caused by Radiation Therapy

Completed · Phase 3

NCT00004316

Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis

Completed · Phase 1|Phase 2

NCT00008476

Capsaicin to Control Pain Following Third Molar Extraction

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42016035254

Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: an individual patient data meta-analysis

Osteoarthritis is the most common joint disorder, and frequently affects the kne

CRD42018079825

Capsaicin as an ergogenic aid: a systematic review

Our group recently demonstrated that acute capsaicin supplementation (12 mg) inc

CRD42020181639

The effectiveness, efficacy and adverse events of topical capsaicin to treat cutaneous itch: a systematic review and meta-analysis

Topical capsaicin to treat patients with cutaneous itch conditions or itch-assoc

📚 Sample References

PMID 31635402

Capsaicin Targets tNOX (ENOX2) to Inhibit G1 Cyclin/CDK Complex, as Assessed by the Cellular Thermal Shift Assay (CETSA)

Cells · 2019

PMID 31782192

Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway

Phytother Res · 2020

PMID 32375895

Immunomodulatory and anti-oxidative effect of the direct TRPV1 receptor agonist capsaicin on Schwann cells

J Neuroinflammation · 2020

⚗️ All Ingredient data fields for Capsaicin

⚗️ Identity

Name

Capsaicin

Aliases / Synonyms

404-86-4; (E)-Capsaicin; Zostrix; CAPSAICINE; Qutenza; Styptysat; Axsain; trans-Capsaicin; Isodecenoic acid vanillylamide

🧪 Chemistry

Molecular Weight

305.4180

LogP

3.7896

Drug-likeness

0.539

Oral Bioavailability

10.3100

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

Isomeric SMILES

CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC

InChIKey

YKPUWZUDDOIDPM-SOFGYWHQSA-N

InChI

InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+

🔗 External References

HERB DB

HBIN019690 ↗

PubChem CID

1548943 ↗

CAS Number

404-86-4 ↗

NPASS

NPC255550

HIT

C1214

SymMap

161

TCMID

3141; 33991; 32304

TCMSP

MOL002579

TCM-ID

5899

🔍 Raw view — every non-empty column on this row (34 fields)

name

Capsaicin

common names

404-86-4; (E)-Capsaicin; Zostrix; CAPSAICINE; Qutenza; Styptysat; Axsain; trans-Capsaicin; Isodecenoic acid vanillylamide

herb ingredient id

HBIN019690

canonical smiles

CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

isomeric smiles

CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC

inchi

InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+

inchikey

YKPUWZUDDOIDPM-SOFGYWHQSA-N

mol wt

305.4180

num h acceptors

num h donors

mol logp

3.7896

num rotatable bonds

drug likeness

0.539

ob score

10.3100

cas id

404-86-4

symmap mol id

161

tcmid ingredient id

3141; 33991; 32304

tcmsp ingredient id

MOL002579

tcm id ingredient id

5899

pubchem cid

1548943

npass id

NPC255550

hit id

C1214

🏥 Linked Health Topics

9 · studied for these conditions (text bridge)

Non-Allergic Rhinitis

syndrome

Neuropathic Pain

phenotype

📋 Clinical Trials

12 · subject of clinical study

NCT00003610 Capsaicin Lozenges in Treating Patients With Mucositis Caused by Radiation Thera

→ Head and Neck Cancer|Radiation Toxicity

NCT00004316 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cy

→ Interstitial Cystitis|Vulvar Diseases

NCT00008476 Capsaicin to Control Pain Following Third Molar Extraction

→ Facial Pain

NCT00088686 Capsaicin to Control Pain Following Third Molar Extraction

→ Healthy|Tooth Extraction

NCT00176969 Response of Topical Capsaicin in Alopecia Areata

→ Alopecia Areata

NCT00471055 Efficacy Study on Symptomatic Control of Patient With Knee Osteoarthritis Betwee

→ Osteoarthritis, Knee Joint|Capsicum

NCT00583180 Sensory Function After Wound Instillation of Capsaicin

→ Primary Hyperalgesia

NCT00993070 Efficacy and Safety Study of Topical Capsaicin in Painful Diabetic Neuropathy

→ Diabetic Polyneuropathy

NCT01223820 Neuro-immunological Analysis of Idiopathic Rhinitis Patients and Controls Treate

→ Idiopathic Rhinitis Patients|Healthy Controls

NCT01533428 A Study to Evaluate Efficacy and Safety of a Single Application of Capsaicin 8%T

→ Diabetic Peripheral Neuropathy|Pain

NCT01540877 A Human Experimental Model for Neuropathic Pain Using Combined Application of Ca

→ Ipsi- and Contralateral Hypoesthesia

NCT01667523 The Effect of Capsaicin and Cinnamaldehyde on Intestinal Permeability

→ Healthy

📊 Meta-Analyses

12 · systematic review

CRD42016035254 Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical c

→ Osteoarthritis is the most common joint disorder,

CRD42018079825 Capsaicin as an ergogenic aid: a systematic review

→ Our group recently demonstrated that acute capsaic

CRD42020181639 The effectiveness, efficacy and adverse events of topical capsaicin to treat cut

→ Topical capsaicin to treat patients with cutaneous

CRD42020213306 Efficacy of pain management in adult patients with diabetic peripheral neuropath

→ Diabetic peripheral neuropathy involves neurovascu

CRD42021227824 Efficacy of Capsaicin for Cannabinoid hyperemesis syndrome in the Emergency Depa

→ Cannabinoid hyperemesis syndrome (CHS) is a condit

CRD42021228032 The Effects of Capsaicin Supplementation on Blood Lipid levels and Inflammatory

→ Dyslipidemia is an important risk factor for many

CRD42021252461 Effects of capsaicin on weight control outcomes in adults: systematic review

→ Excess weight is a relevant problem for public hea

CRD42021262605 Capsaicin for the treatment of non-allergic rhinitis: a systematic review

→ Non-allergic rhinitis.

CRD42021274702 Meta-analysis of the effects of consumption of capsaicin/capsaicin-containing bi

→ With the development of society and economy, the l

CRD42021278763 Comparative efficacy and safety of intraarticular injection of lidocaine and cap

→ Knee osteoarthritis（KOA）is a common chronic degene

CRD42021285398 A systematic review and meta-analysis of capsaicin for osteoarthritis

→ Capsaicin for osteoarthritis.

CRD42022320884 The therapeutic effect of capsaicin on swallowing function associated with aging

→ Deterioration of swallowing function is caused by

📚 PubMed References

12 · cited research

PMID 31635402 Capsaicin Targets tNOX (ENOX2) to Inhibit G1 Cyclin/CDK Complex, as Assessed by

Cells

PMID 31782192 Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt

Phytother Res

PMID 32375895 Immunomodulatory and anti-oxidative effect of the direct TRPV1 receptor agonist

J Neuroinflammation

PMID 32685028 Therapeutic potential of targeting MKK3-p38 axis with Capsaicin for Nasopharynge

Theranostics

PMID 32982728 Capsaicin Is a Negative Allosteric Modulator of the 5-HT3 Receptor

Front Pharmacol

PMID 33016967 Eugenol and capsaicin exhibit anti-metastatic activity via modulating TGF-β sign

Food Funct

PMID 33163267 Capsaicin acts through tNOX (ENOX2) to induce autophagic apoptosis in p53-mutate

Am J Cancer Res

PMID 33986684 Capsaicin protects cardiomyocytes against lipopolysaccharide-induced damage via

Front Pharmacol

PMID 34205555 TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Inde

Cells

PMID 34445392 Bacterial Antigens Reduced the Inhibition Effect of Capsaicin on Cal 27 Oral Can

Int J Mol Sci

PMID 34512323 Capsaicin Potentiates Anticancer Drug Efficacy Through Autophagy-Mediated Riboph

Front Pharmacol

PMID 34659883 Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting

Am J Cancer Res

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables