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Disease
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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⚗️ Ingredient

Carnosine

Open on HERB 2.0 ↗
12
Clinical Trials
10
Meta-Analyses
13
PubMed References
Top Conditions Studied with Carnosine
Attention Deficit Hyperactivity Disorder 1 Carnosine 1 Type 1 Diabetes|Oxidative Stress|Carnosine|Diabetic Nephropa 1 Bipolar I Disorder 1 Type 2 diabetes and cardiovascular disease are major health 1 Schizophrenia|Schizoaffective Disorder 1 The cause of senile cataract in the aging eye is believed to 1 Schizophrenia 1 The aging population resulted in the rising of cancer, cardi 1 Persian Gulf Syndrome 1 Overweight and obesity 1 Peripheral Neuropathy|Cancer 1
📋 Sample Trials
NCT00177177
L-carnosine for Schizophrenia
Completed
NCT00177463
L-Carnosine for Bipolar I Disorder
Completed
NCT00721708
Pharmacokinetics of Carnosine
Completed
📊 Sample Meta-Analyses
CRD42017075354
Effect of Carnosine supplementation on health outcomes: a systematic review and meta analysis of randomised controlled trials
Type 2 diabetes and cardiovascular disease are major health threats growing in n
CRD42020191588
The effect of carnosine or beta-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis
Glycaemic control and insulin resistance.
CRD42020146229
Effect of L-Carnosine on children with Autism Spectrum Disorders: A systematic review and meta-analysis of randomised controlled trials
Autism Spectrum Disorders
📚 Sample References
PMID 30658430
Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1
Cells · 2019
PMID 28826042
Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage
Redox Biol · 2018
PMID 32134423
Carnosine ameliorates age-related dementia via improving mitochondrial dysfunction in SAMP8 mice
Food Funct · 2020
⚗️ All Ingredient data fields for Carnosine
⚗️ Identity
Name
Carnosine
Aliases / Synonyms
L-Carnosine; 305-84-0; beta-Alanyl-L-histidine; Ignotine; Karnozin; Karnozzn; L-Histidine, beta-alanyl-; L-Ignotine; N-2-M
🧪 Chemistry
Molecular Weight
226.2360
LogP
-1.1296
Drug-likeness
0.489
H-Bond Acceptors
4
H-Bond Donors
4
Rotatable Bonds
6
🔬 Structures
Canonical SMILES
C1=C(NC=N1)CC(C(=O)O)NC(=O)CCN
Isomeric SMILES
C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)CCN
InChIKey
CQOVPNPJLQNMDC-ZETCQYMHSA-N
InChI
InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
🔗 External References
HERB DB
HBIN019758 ↗
PubChem CID
439224 ↗
HIT
C0175
TCMID
3205
🔍 Raw view — every non-empty column on this row (28 fields)
name
Carnosine
common names
L-Carnosine; 305-84-0; beta-Alanyl-L-histidine; Ignotine; Karnozin; Karnozzn; L-Histidine, beta-alanyl-; L-Ignotine; N-2-M
herb ingredient id
HBIN019758
canonical smiles
C1=C(NC=N1)CC(C(=O)O)NC(=O)CCN
isomeric smiles
C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)CCN
inchi
InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1
inchikey
CQOVPNPJLQNMDC-ZETCQYMHSA-N
mol wt
226.2360
num h acceptors
4
num h donors
4
mol logp
-1.1296
num rotatable bonds
6
drug likeness
0.489
tcmid ingredient id
3205
pubchem cid
439224
hit id
C0175

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)
Diabetic Neuropathies
group
Multiple Sclerosis
syndrome
Schizophrenia
disease
Persian Gulf Syndrome
syndrome
Bipolar I Disorder
disease

📋 Clinical Trials

12 · subject of clinical study
NCT00177177 L-carnosine for Schizophrenia
→ Schizophrenia|Schizoaffective Disorder
NCT00177463 L-Carnosine for Bipolar I Disorder
→ Bipolar I Disorder
NCT00721708 Pharmacokinetics of Carnosine
→ Oxidative Stress
NCT00810368 Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
→ Persian Gulf Syndrome
NCT02011100 Effect of Carnosine on Diabetes and Cardiovascular Risk Factors
→ Metabolic Diseases, Type 2 Diabetes, Cardiovascula
NCT02686697 Carnosine and Cognitive Training in Schizophrenia
→ Schizophrenia
NCT02928250 Role of Carnosine as an Adjuvant Therapy for Diabetic Nephropathy in Pediatrics
→ Type 1 Diabetes|Oxidative Stress|Carnosine|Diabeti
NCT03844113 Carnosine for Peripheral Vascular Disease
→ Peripheral Arterial Disease
NCT03995810 Oral Carnosine for Neuromuscular Performance in Multiple Sclerosis
→ Multiple Sclerosis
NCT02808624 L-carnosine Prophylactic Effect on Oxaliplatin Induced Peripheral Neuropathy in
→ Peripheral Neuropathy|Cancer
NCT05422352 Role of Carnosine in Combination With Vitamin B Complex in Preventing the Progre
→ Diabetic Neuropathies
NCT05723939 Carnosine Supplementation and Cardiovascular Function
→ Carnosine

📊 Meta-Analyses

10 · systematic review
CRD42017075354 Effect of Carnosine supplementation on health outcomes: a systematic review and
→ Type 2 diabetes and cardiovascular disease are maj
CRD42020191588 The effect of carnosine or beta-alanine supplementation on markers of glycaemic
→ Glycaemic control and insulin resistance.
CRD42020146229 Effect of L-Carnosine on children with Autism Spectrum Disorders: A systematic r
→ Autism Spectrum Disorders
CRD42020168567 Effectiveness and safety of Carnosine supplementation in behavioral disorders in
→ Autism Spectrum Disorder (ASD)
CRD42020209818 Effect of L-Carnosine in children with Attention Deficit Hyperactivity Disorder:
→ Attention Deficit Hyperactivity Disorder
CRD42022314033 Effect of L-carnosine in patients with age-related diseases: A systematic review
→ The aging population resulted in the rising of can
CRD42022349231 Polaprezinc "zinc carnosine" as an adjuvant to triple therapy for the ma
→ H pylori is an extremely common organism infecting
CRD42022352602 N-acetylcarnosine as a Topical Treatment for Age-Related Cataracts: A Systematic
→ The cause of senile cataract in the aging eye is b
CRD42023472430 Effect of glutamatergic medications for obsessive-compulsive and related disorde
→ Obsessive-compulsive and related disorders (OCRD):
CRD42023481654 L-carnosine for adults with overweight and obesity: a systematic review of rando
→ Overweight and obesity

📚 PubMed References

12 · cited research
PMID 30658430 Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Ce
Cells
PMID 28826042 Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducin
Redox Biol
PMID 32134423 Carnosine ameliorates age-related dementia via improving mitochondrial dysfuncti
Food Funct
PMID 32664451 A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Conc
Int J Mol Sci
PMID 32782394 Carnosine suppresses human glioma cells under normoxic and hypoxic conditions pa
Acta Pharmacol Sin
PMID 32899420 Carnosine Impedes PDGF-Stimulated Proliferation and Migration of Vascular Smooth
Nutrients
PMID 33241846 Carnosine alleviates diabetic nephropathy by targeting GNMT, a key enzyme mediat
Clin Sci (Lond)
PMID 33390976 Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Throu
Front Pharmacol
PMID 33768569 Carnosine improves aging-induced cognitive impairment and brain regional neurode
J Neurochem
PMID 34299128 Carnosine Protects against Cerebral Ischemic Injury by Inhibiting Matrix-Metallo
Int J Mol Sci
PMID 35091983 Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in
J Physiol Biochem
PMID 35740105 Carnosine Alleviates Knee Osteoarthritis and Promotes Synoviocyte Protection via
Antioxidants (Basel)
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables