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trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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⚗️ Ingredient

Cepharanthine

Open on HERB 2.0 ↗
1
Clinical Trials
0
Meta-Analyses
7
PubMed References
Top Conditions Studied with Cepharanthine
Asymptomatic COVID-19 1
📋 Sample Trials
NCT05398705
Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitalized Adults With COVID-19
Completed · Phase 2
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 31699152
Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosome fusion through blockade of the F-actin network
J Exp Clin Cancer Res · 2019
PMID 29024815
Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer
Cancer Lett · 2018
PMID 28923401
Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth
Cancer Lett · 2017
⚗️ All Ingredient data fields for Cepharanthine
⚗️ Identity
Name
Cepharanthine
Aliases / Synonyms
481-49-2; Cepharanthin; (+)-Cepharanthine; O-Methylcepharanoline; Cepharantin; Cepharanthine [JAN]; CCRIS 6539; 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan; Cepharanthine (TN)
🧪 Chemistry
Molecular Weight
606.7190
LogP
6.8739
Drug-likeness
0.245
Oral Bioavailability
77.4180
H-Bond Acceptors
8
Rotatable Bonds
2
🔬 Structures
Canonical SMILES
CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
Isomeric SMILES
CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
InChIKey
YVPXVXANRNDGTA-WDYNHAJCSA-N
InChI
InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1
🔗 External References
HERB DB
HBIN020124 ↗
PubChem CID
10206 ↗
CAS Number
481-49-2 ↗
NPASS
NPC73492
SymMap
671
TCMID
3412
TCMSP
MOL006973
TCM-ID
5813
🔍 Raw view — every non-empty column on this row (33 fields)
name
Cepharanthine
common names
481-49-2; Cepharanthin; (+)-Cepharanthine; O-Methylcepharanoline; Cepharantin; Cepharanthine [JAN]; CCRIS 6539; 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan; Cepharanthine (TN)
herb ingredient id
HBIN020124
canonical smiles
CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
isomeric smiles
CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
inchi
InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1
inchikey
YVPXVXANRNDGTA-WDYNHAJCSA-N
mol wt
606.7190
num h acceptors
8
num h donors
0
mol logp
6.8739
num rotatable bonds
2
drug likeness
0.245
ob score
77.4180
cas id
481-49-2
symmap mol id
671
tcmid ingredient id
3412
tcmsp ingredient id
MOL006973
tcm id ingredient id
5813
pubchem cid
10206
npass id
NPC73492

📋 Clinical Trials

1 · subject of clinical study
NCT05398705 Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitali
→ Asymptomatic COVID-19

📚 PubMed References

7 · cited research
PMID 31699152 Downregulation of MYO1C mediated by cepharanthine inhibits autophagosome-lysosom
J Exp Clin Cancer Res
PMID 29024815 Identification of a novel autophagic inhibitor cepharanthine to enhance the anti
Cancer Lett
PMID 28923401 Pharmacological blockade of cholesterol trafficking by cepharanthine in endothel
Cancer Lett
PMID 21628669 Genetic variants of ABCC10, a novel tenofovir transporter, are associated with k
J Infect Dis
PMID 34956164 Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Dow
Front Microbiol
PMID 35186185 Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mic
Oxid Med Cell Longev
PMID 35800437 Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regul
Front Pharmacol
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables