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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Chenodeoxycholic acid

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Chenodeoxycholic acid

Severe Obesity 2 Cerebrotendinous Xanthomatoses 2

📋 Sample Trials

NCT02340247

Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass

Completed · Phase 4

NCT02876484

Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass

Completed · Phase 4

NCT05499026

Safety and Efficacy of CDCA in CTX Chenodeoxycholic Acid (CDCA) in Patients Affected by Cerebrotendinous Xanthomatosis (CTX)

Completed

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 31268738

Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea

FASEB J · 2019

PMID 28378364

Chenodeoxycholic acid stimulated fibroblast growth factor 19 response - a potential biochemical test for bile acid diarrhoea

Aliment Pharmacol Ther · 2017

PMID 28145001

Treatment with the natural FXR agonist chenodeoxycholic acid reduces clearance of plasma LDL whilst decreasing circulating PCSK9, lipoprotein(a) and apolipoprotein C-III

J Intern Med · 2017

⚗️ All Ingredient data fields for Chenodeoxycholic acid

⚗️ Identity

Name

Chenodeoxycholic acid

Aliases / Synonyms

Chenodiol; 474-25-9; Chenix; Chenic acid; Chenodesoxycholic acid; Cdca; Chenodeoxycholate; Gallodesoxycholic acid; Chendol

🧪 Chemistry

Molecular Weight

392.5800

LogP

4.4779

Drug-likeness

0.659

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

Isomeric SMILES

C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

InChIKey

RUDATBOHQWOJDD-BSWAIDMHSA-N

InChI

InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1

🔗 External References

HERB DB

HBIN020281 ↗

PubChem CID

10133 ↗

NPASS

NPC34046

HIT

C1228

TCMID

24254

TCM-ID

5778

🔍 Raw view — every non-empty column on this row (30 fields)

name

Chenodeoxycholic acid

common names

Chenodiol; 474-25-9; Chenix; Chenic acid; Chenodesoxycholic acid; Cdca; Chenodeoxycholate; Gallodesoxycholic acid; Chendol

herb ingredient id

HBIN020281

canonical smiles

CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

isomeric smiles

C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

inchi

InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1

inchikey

RUDATBOHQWOJDD-BSWAIDMHSA-N

mol wt

392.5800

num h acceptors

num h donors

mol logp

4.4779

num rotatable bonds

drug likeness

0.659

tcmid ingredient id

24254

tcm id ingredient id

5778

pubchem cid

10133

npass id

NPC34046

hit id

C1228

📋 Clinical Trials

4 · subject of clinical study

NCT02340247 Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass

→ Severe Obesity

NCT02876484 Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-e

→ Severe Obesity

NCT05499026 Safety and Efficacy of CDCA in CTX Chenodeoxycholic Acid (CDCA) in Patients Affe

→ Cerebrotendinous Xanthomatoses

NCT06180057 Bioequivalence Study to Compare Chenodeoxycholic Acid Capsules (250mg Chenodeoxy

→ Cerebrotendinous Xanthomatoses

📚 PubMed References

11 · cited research

PMID 31268738 Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy f

FASEB J

PMID 28378364 Chenodeoxycholic acid stimulated fibroblast growth factor 19 response - a potent

Aliment Pharmacol Ther

PMID 28145001 Treatment with the natural FXR agonist chenodeoxycholic acid reduces clearance o

J Intern Med

PMID 26888164 Effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glu

Diabetes Obes Metab

PMID 26235421 The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activit

Cell Metab

PMID 23783097 Effects of chenodeoxycholic acid on the secretion of gut peptides and fibroblast

J Clin Endocrinol Metab

PMID 21649640 Scoparone potentiates transactivation of the bile salt export pump gene and this

Br J Pharmacol

PMID 21499302 Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growt

Oncogene

PMID 33193099 Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/Apo

Front Endocrinol (Lausanne)

PMID 35364069 Chenodeoxycholic acid inhibits lung adenocarcinoma progression via the integrin

Eur J Pharmacol

PMID 36421471 Chenodeoxycholic Acid (CDCA) Promoted Intestinal Epithelial Cell Proliferation b

Antioxidants (Basel)

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables