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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Citric acid

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Citric acid

Gingival Recession 2 Acute Kidney Injury|Acute Kidney Failure|Renal Replacement T 1 The smear layer is an amorphous film that is always formed b 1 Methods of citric acid cough reflex testing, across discipli 1 Comparison of properties between the main chelating agents u 1 Iron Deficiency and/or Anemia 1 Intrabony Periodontal Defect 1 Helicobacter Pylori Infection 1

📋 Sample Trials

NCT02259543

Root Biomodification With Citric Acid and Tetracycline Improves the Outcomes of Root Coverage

Completed

NCT02359942

The Diagnostic Validity of the Urea Breath Test

Completed

NCT02714075

Comparison of Iron Absorption From Extruded FePP-fortified Rice Containing Zinc, Citric Acid/Trisodium Citrate and EDTA

Completed

📊 Sample Meta-Analyses

CRD42017079055

Systematic review of methods of citric acid cough reflex testing

Methods of citric acid cough reflex testing, across disciplines.

CRD42022308329

Effect of commonly used endodontic chelators (such as Etidronic acid, citric acid, QMix and others) on radicular dentine: A systematic review.

The smear layer is an amorphous film that is always formed by the action of endo

CRD42023425927

Update on chelating agents in endodontic treatment: a systematic review

Comparison of properties between the main chelating agents used in endodontics

📚 Sample References

PMID 33888605

Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Channel 1

J Neurosci · 2021

⚗️ All Ingredient data fields for Citric acid

⚗️ Identity

Name

Citric acid

Aliases / Synonyms

77-92-9; Citric acid, anhydrous; 2-hydroxypropane-1,2,3-tricarboxylic acid; Anhydrous citric acid; Aciletten; Citro; Citretten; Chemfill; Citric acid anhydrous

🧪 Chemistry

Molecular Weight

192.1230

LogP

-1.2485

Drug-likeness

0.427

Oral Bioavailability

56.2200

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Isomeric SMILES

C(C(=O)O)C(CC(=O)O)(C(=O)O)O

InChIKey

KRKNYBCHXYNGOX-UHFFFAOYSA-N

InChI

InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

🔗 External References

HERB DB

HBIN020984 ↗

PubChem CID

311 ↗

CAS Number

77-92-9 ↗

HIT

C1246

TCMID

23224

TCMSP

MOL001456

TCM-ID

5608

🔍 Raw view — every non-empty column on this row (32 fields)

name

Citric acid

common names

77-92-9; Citric acid, anhydrous; 2-hydroxypropane-1,2,3-tricarboxylic acid; Anhydrous citric acid; Aciletten; Citro; Citretten; Chemfill; Citric acid anhydrous

herb ingredient id

HBIN020984

canonical smiles

C(C(=O)O)C(CC(=O)O)(C(=O)O)O

isomeric smiles

C(C(=O)O)C(CC(=O)O)(C(=O)O)O

inchi

InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

inchikey

KRKNYBCHXYNGOX-UHFFFAOYSA-N

mol wt

192.1230

num h acceptors

num h donors

mol logp

-1.2485

num rotatable bonds

drug likeness

0.427

ob score

56.2200

cas id

77-92-9

tcmid ingredient id

23224

tcmsp ingredient id

MOL001456

tcm id ingredient id

5608

pubchem cid

311

hit id

C1246

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Gingival Recession

syndrome

📋 Clinical Trials

6 · subject of clinical study

NCT02259543 Root Biomodification With Citric Acid and Tetracycline Improves the Outcomes of

→ Gingival Recession

NCT02359942 The Diagnostic Validity of the Urea Breath Test

→ Helicobacter Pylori Infection

NCT02714075 Comparison of Iron Absorption From Extruded FePP-fortified Rice Containing Zinc,

→ Iron Deficiency and/or Anemia

NCT03095378 Evaluation of Root Coverage by Connective Graft and Different Root Conditioning

→ Gingival Recession

NCT03769402 The Influence of Citric Acid Bone Surface Etching and Bone Defect Fill on GCF BM

→ Intrabony Periodontal Defect

NCT03836742 HEmoFiltration With Citric Acid Anticoagulation

→ Acute Kidney Injury|Acute Kidney Failure|Renal Rep

📊 Meta-Analyses

3 · systematic review

CRD42017079055 Systematic review of methods of citric acid cough reflex testing

→ Methods of citric acid cough reflex testing, acros

CRD42022308329 Effect of commonly used endodontic chelators (such as Etidronic acid, citric aci

→ The smear layer is an amorphous film that is alway

CRD42023425927 Update on chelating agents in endodontic treatment: a systematic review

→ Comparison of properties between the main chelatin

📚 PubMed References

1 · cited research

PMID 33888605 Citric Acid in Drug Formulations Causes Pain by Potentiating Acid-Sensing Ion Ch

J Neurosci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables