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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Citrulline

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Citrulline

Mitochondrial Diseases 1 Cardiovascular Diseases|Heart Diseases|Heart Defects, Congen 1 The domain being studied is within the field of exercise per 1 Metabolism|Elderly 1 Atorvastatin 1 Recovering after a physical fitness 1 Menopause 1 Physical exercise, both aerobic and anaerobic 1 MELAS Syndrome 1 It has been suggested that citrulline (CIT; a non-proteinoge 1 Intestinal Failure 1 Fatigue during physical performance and potential nitric oxi 1

📋 Sample Trials

NCT00201214

Citrulline for Children Undergoing Cardiopulmonary Bypass Surgery

Completed · Phase 1|Phase 2

NCT00714675

Citrulline and Protein Metabolism in the Malnourished Elderly People

Completed

NCT01599676

Citrulline, Exercise Training and Muscle Strength in the Elderly

Completed

📊 Sample Meta-Analyses

CRD42019115488

The effect of L-citrulline on the subjective feeling of fatigue and exercise performance

Physical exercise, both aerobic and anaerobic

CRD42019145681

Effects of citrulline alone or combined with exercise on muscle mass, muscle strength and physical performance among older adults: a systematic review (Protocol)

It has been suggested that citrulline (CIT; a non-proteinogenic amino acid) supp

CRD42020159338

Effects of citrulline supplementation on resistance training responses: a systematic review and meta-analysis of randomized controlled trials

The effects of citrulline supplementation on muscle soreness, strength and endur

📚 Sample References

PMID 35460170

Citrulline protects human retinal pigment epithelium from hydrogen peroxide and iron/ascorbate induced damages

J Cell Mol Med · 2022

PMID 36564641

Citrulline enteral administration markedly reduces immunosuppressive extrafollicular plasma cell differentiation in a preclinical model of sepsis

Eur J Immunol · 2022

⚗️ All Ingredient data fields for Citrulline

⚗️ Identity

Name

Citrulline

Aliases / Synonyms

L-citrulline; 372-75-8; H-cit-oh; delta-Ureidonorvaline; Sitrulline; (S)-2-Amino-5-ureidopentanoic acid; N5-Carbamoyl-L-ornithine; L-Cytrulline; Citrulline, L-

🧪 Chemistry

Molecular Weight

175.1880

LogP

-1.1532

Drug-likeness

0.394

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(CC(C(=O)O)N)CNC(=O)N

Isomeric SMILES

C(C[C@@H](C(=O)O)N)CNC(=O)N

InChIKey

RHGKLRLOHDJJDR-BYPYZUCNSA-N

InChI

InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1

🔗 External References

HERB DB

HBIN021006 ↗

PubChem CID

9750 ↗

SymMap

14702

TCMID

3774

TCM-ID

5598

🔍 Raw view — every non-empty column on this row (29 fields)

name

Citrulline

common names

L-citrulline; 372-75-8; H-cit-oh; delta-Ureidonorvaline; Sitrulline; (S)-2-Amino-5-ureidopentanoic acid; N5-Carbamoyl-L-ornithine; L-Cytrulline; Citrulline, L-

herb ingredient id

HBIN021006

canonical smiles

C(CC(C(=O)O)N)CNC(=O)N

isomeric smiles

C(C[C@@H](C(=O)O)N)CNC(=O)N

inchi

InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1

inchikey

RHGKLRLOHDJJDR-BYPYZUCNSA-N

mol wt

175.1880

num h acceptors

num h donors

mol logp

-1.1532

num rotatable bonds

drug likeness

0.394

symmap mol id

14702

tcmid ingredient id

3774

tcm id ingredient id

5598

pubchem cid

9750

🏥 Linked Health Topics

2 · studied for these conditions (text bridge)

Melas Syndrome

syndrome

Mitochondrial Diseases

group

📋 Clinical Trials

12 · subject of clinical study

NCT00201214 Citrulline for Children Undergoing Cardiopulmonary Bypass Surgery

→ Cardiovascular Diseases|Heart Diseases|Heart Defec

NCT00714675 Citrulline and Protein Metabolism in the Malnourished Elderly People

→ Metabolism|Elderly

NCT01599676 Citrulline, Exercise Training and Muscle Strength in the Elderly

→ Elderly Patients

NCT01849107 Plasma Citrulline: A Marker for Monitoring & Quantifying Radiation-Induced Small

→ Diarrhea|Anorexia|Dyspepsia

NCT02417428 Citrulline Supplementation Combined With Exercise: Effect on Muscle Function in

→ Sarcopenia|Obesity

NCT02801695 Evaluation of the Efficacy of Citrulline Supplementation on the Delay of Deliver

→ Pre-eclampsia|Pregnancy

NCT02809170 The Effect of Arginine and Citrulline Supplementation on Endothelial Dysfunction

→ Mitochondrial Diseases

NCT03596684 Citrulline Efficacy to Improve Carbohydrate Metabolism Abnormalities in the Pati

→ Atorvastatin

NCT05143879 Long-Term Effect of Combined Citrulline and Nitrate-Rich Beetroot Extract Supple

→ Citrulline|Nitrate|Athletes

NCT00756080 "Effects of Oral Citrulline on Protein Metabolism in Healthy Humans: a Prospecti

→ Healthy Subjects

NCT00950976 Dose-response Enteral Citrulline for Normal Healthy Volunteers and Surgery Patie

→ Nutritional Deficiency

NCT01339494 Nitric Oxide Production in MELAS Syndrome

→ MELAS Syndrome

📊 Meta-Analyses

6 · systematic review

CRD42019115488 The effect of L-citrulline on the subjective feeling of fatigue and exercise per

→ Physical exercise, both aerobic and anaerobic

CRD42019145681 Effects of citrulline alone or combined with exercise on muscle mass, muscle str

→ It has been suggested that citrulline (CIT; a non-

CRD42020159338 Effects of citrulline supplementation on resistance training responses: a system

→ The effects of citrulline supplementation on muscl

CRD42020179291 The effect of Citrulline supplementation on exercise performance in healthy adul

→ The domain being studied is within the field of ex

CRD42021287530 The effect of L-arginine, L-citrulline and combined L-arginine with L-citrulline

→ Fatigue during physical performance and potential

CRD42022359806 Influence of arginine and citrulline on biomarkers of inflammation and oxidative

→ Recovering after a physical fitness

📚 PubMed References

2 · cited research

PMID 35460170 Citrulline protects human retinal pigment epithelium from hydrogen peroxide and

J Cell Mol Med

PMID 36564641 Citrulline enteral administration markedly reduces immunosuppressive extrafollic

Eur J Immunol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables