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Ingredient
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Gene Target
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Disease
30,170
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
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⚗️ Ingredient

Clr

Open on HERB 2.0 ↗
16
Clinical Trials
0
Meta-Analyses
6
PubMed References
Top Conditions Studied with Clr
Smith-Lemli-Opitz Syndrome 2 Septic Patients|Nonseptic Patients 1 Coronary Artery Disease 1 Pancreatic Ductal Adenocarcinoma|Pancreatic Cancer|Pancreas 1 Autism|Asperger Disorder|PDD-NOS 1 Lipids 1 Lipid Metabolism Disorders|Sterols|Diet, High-Fat|Cholestero 1 Lipid Metabolism 1 Hyperlipidemia|Cardiovascular Diseases|Hypercholesterolemia 1 Hypercholesterolemia|Insulin Resistance|Insulin Secretion 1 Hypercholesterolemia|Cognitive Dysfunction|Hyperhomocysteine 1 Healthy 1
📋 Sample Trials
NCT00114634
Short-term Behavioral Effects of Cholesterol Therapy in Smith-Lemli-Opitz Syndrome
Completed · Phase 2
NCT00272844
Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome
Completed · Phase 1|Phase 2
NCT00328211
Intralumenal Effects on Cholesterol Absorption/Synthesis
Completed
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 32197645
High cholesterol induces apoptosis and autophagy through the ROS-activated AKT/FOXO1 pathway in tendon-derived stem cells
Stem Cell Res Ther · 2020
PMID 32566088
Cholesterol Induces Nrf-2- and HIF-1 α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis
Oxid Med Cell Longev · 2020
PMID 32751976
Cholesterol and Mevalonate: Two Metabolites Involved in Breast Cancer Progression and Drug Resistance through the ERRα Pathway
Cells · 2020
⚗️ All Ingredient data fields for Clr
⚗️ Identity
Name
Clr
Aliases / Synonyms
cholesterol; 57-88-5; Cholesterin; Cholest-5-en-3beta-ol; Cholesteryl alcohol; Dythol; Cholestrin; Cordulan; Dusoline; Dusoran
🧪 Chemistry
Molecular Weight
386.6640
LogP
7.3887
Drug-likeness
0.488
Oral Bioavailability
37.8740
H-Bond Acceptors
1
H-Bond Donors
1
Rotatable Bonds
5
🔬 Structures
Canonical SMILES
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
Isomeric SMILES
C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
InChIKey
HVYWMOMLDIMFJA-DPAQBDIFSA-N
InChI
InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
🔗 External References
HERB DB
HBIN021150 ↗
PubChem CID
5997 ↗
CAS Number
80356-14-5 ↗
NPASS
NPC28657
HIT
C1234
SymMap
3442
TCMSP
MOL000953
🔍 Raw view — every non-empty column on this row (32 fields)
name
Clr
common names
cholesterol; 57-88-5; Cholesterin; Cholest-5-en-3beta-ol; Cholesteryl alcohol; Dythol; Cholestrin; Cordulan; Dusoline; Dusoran
herb ingredient id
HBIN021150
canonical smiles
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
isomeric smiles
C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
inchi
InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
inchikey
HVYWMOMLDIMFJA-DPAQBDIFSA-N
mol wt
386.6640
num h acceptors
1
num h donors
1
mol logp
7.3887
num rotatable bonds
5
drug likeness
0.488
ob score
37.8740
cas id
80356-14-5
symmap mol id
3442
tcmsp ingredient id
MOL000953
pubchem cid
5997
npass id
NPC28657
hit id
C1234

🏥 Linked Health Topics

3 · studied for these conditions (text bridge)
Glaucoma
syndrome
Smith-Lemli-Opitz Syndrome
syndrome
Coronary Artery Disease
syndrome

📋 Clinical Trials

12 · subject of clinical study
NCT00114634 Short-term Behavioral Effects of Cholesterol Therapy in Smith-Lemli-Opitz Syndro
→ Smith-Lemli-Opitz Syndrome
NCT00272844 Treatment of the Cholesterol Defect in Smith-Lemli-Opitz Syndrome
→ Smith-Lemli-Opitz Syndrome
NCT00328211 Intralumenal Effects on Cholesterol Absorption/Synthesis
→ Healthy
NCT00965068 Cholesterol in ASD: Characterization and Treatment
→ Autism|Asperger Disorder|PDD-NOS
NCT01773278 Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrom
→ Smith-Lemli-Opitz Syndrome|Cone-Rod Dystrophy|Hear
NCT02065817 Dose of Labeled Cholesterol for Kinetics: A Pilot Study
→ Lipid Metabolism
NCT02549144 Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition a
→ Lipids
NCT03359369 Prognostic Value of Serum Cholesterol and Triglyceride in Septic and Non Septic
→ Septic Patients|Nonseptic Patients
NCT03631238 The Dual Impact of Homocysteine and Cholesterol on Cognitive Functions
→ Hypercholesterolemia|Cognitive Dysfunction|Hyperho
NCT03698929 Effect of Dietary Cholesterol on Plasma Lipids
→ Dietary Modification|Nutritional and Metabolic Dis
NCT04862260 Cholesterol Disruption in Combination With the Standard of Care in Patients With
→ Pancreatic Ductal Adenocarcinoma|Pancreatic Cancer
NCT00438893 Effects of a Long Term Dietary Portfolio and of Sequential Removal of Food Compo
→ Hyperlipidemia|Cardiovascular Diseases|Hypercholes

📚 PubMed References

6 · cited research
PMID 32197645 High cholesterol induces apoptosis and autophagy through the ROS-activated AKT/F
Stem Cell Res Ther
PMID 32566088 Cholesterol Induces Nrf-2- and HIF-1 α-Dependent Hepatocyte Proliferation and Li
Oxid Med Cell Longev
PMID 32751976 Cholesterol and Mevalonate: Two Metabolites Involved in Breast Cancer Progressio
Cells
PMID 33685483 Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal c
Mol Neurodegener
PMID 33842002 Ca2+-activated Cl- channel TMEM16A inhibition by cholesterol promotes angiogenes
J Adv Res
PMID 34054517 Cholesterol Stimulates the Transient Receptor Potential Melastatin 4 Channel in
Front Pharmacol
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables