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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Codeine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Codeine

Pain, Postoperative 2 The Cochrane Pain, Palliative and Supportive Care Group 2 Sciatica Acute|Sciatica 1 Depressive Disorder, Major|Diabetic Neuropathies|Fibromyalgi 1 Opioid use disorder/opioid dependence. Opioid agonist treatm 1 Postoperative Dental Pain 1 Acute Pain Due to Trauma 1 Opioid prescribing and consumption in otolaryngology ambulat 1 Postcraniotomy Pain 1 Coughs, regardless of etiology. 1 Post-operative Pain Control 1 Codeine dependence. 1

📋 Sample Trials

NCT04202406

Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Success in Patients With Acute Pulpitis

Completed

NCT00174538

Codeine in Sickle Cell Disease

Completed · Phase 1|Phase 2

NCT00474721

Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries

Completed

📊 Sample Meta-Analyses

CRD42015018975

Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain [Cochrane Protocol]

The Cochrane Pain, Palliative and Supportive Care Group

CRD42016033604

Codeine versus placebo for chronic cough in children [Cochrane Protocol]

The Cochrane Airways Group

CRD42016045967

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults [Cochrane Protocol]

The Cochrane Pain, Palliative and Supportive Care Group

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Codeine

⚗️ Identity

Name

Codeine

Aliases / Synonyms

Methylmorphine; Codeine anhydrous; Codicept; Coducept; l-Codeine; 76-57-3; Morphine monomethyl ether; O3-Methylmorphine; (-)-Codeine

🧪 Chemistry

Molecular Weight

299.3700

LogP

1.5011

Drug-likeness

0.798

Oral Bioavailability

45.4790

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O

Isomeric SMILES

CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O

InChIKey

OROGSEYTTFOCAN-DNJOTXNNSA-N

InChI

InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1

🔗 External References

HERB DB

HBIN021216 ↗

PubChem CID

5284371 ↗

CAS Number

76-57-3 ↗

NPASS

NPC43069

HIT

C1249

SymMap

258

TCMID

3885

TCMSP

MOL006982

TCM-ID

5546

🔍 Raw view — every non-empty column on this row (34 fields)

name

Codeine

common names

Methylmorphine; Codeine anhydrous; Codicept; Coducept; l-Codeine; 76-57-3; Morphine monomethyl ether; O3-Methylmorphine; (-)-Codeine

herb ingredient id

HBIN021216

canonical smiles

CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O

isomeric smiles

CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O

inchi

InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1

inchikey

OROGSEYTTFOCAN-DNJOTXNNSA-N

mol wt

299.3700

num h acceptors

num h donors

mol logp

1.5011

num rotatable bonds

drug likeness

0.798

ob score

45.4790

cas id

76-57-3

symmap mol id

258

tcmid ingredient id

3885

tcmsp ingredient id

MOL006982

tcm id ingredient id

5546

pubchem cid

5284371

npass id

NPC43069

hit id

C1249

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

Esophageal Motility Disorders

Symptomatic Irreversible Pulpitis

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT04202406 Preoperative Acetaminophen- Caffeine- Codeine Combination and Anaesthetic Succes

→ Symptomatic Irreversible Pulpitis

NCT00174538 Codeine in Sickle Cell Disease

→ Sickle Cell Disease

NCT00474721 Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injurie

→ Pain

NCT00699114 Analgesic Effect of Ibuprofen, Paracetamol (Acetaminophen), and Paracetamol (Ace

→ Surgery

NCT01267136 A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Chil

→ Tonsillitis|Pain

NCT01322204 Codeine in Mechanically Ventilated Neonates

→ Mechanically Ventilated Neonates|Painful Procedure

NCT02647788 Acetaminophen/Codeine vs Acetaminophen/Ibuprofen for Pain Control and Patient Sa

→ Pain, Postoperative

NCT04399122 Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetamin

→ Post-operative Pain Control

NCT04730297 Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After

→ To Control Pain After Third Molar Surgery

NCT00456898 Study Evaluating the Potential of DVS SR to Inhibit the CYP2D6 Pathway

→ Depressive Disorder, Major|Diabetic Neuropathies|F

NCT00694369 A Study to Asses the Effect of MK0663 in the Treatment of Patients With Postoper

→ Postoperative Dental Pain

NCT00784810 A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paraceta

→ Osteoarthritis|Back Pain

📊 Meta-Analyses

11 · systematic review

CRD42015018975 Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, app

→ The Cochrane Pain, Palliative and Supportive Care

CRD42016033604 Codeine versus placebo for chronic cough in children [Cochrane Protocol]

→ The Cochrane Airways Group

CRD42016045967 Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neurop

→ The Cochrane Pain, Palliative and Supportive Care

CRD42016052129 Identification and treatment of codeine dependence: a systematic review

→ Codeine dependence.

CRD42019123095 The efficacy of codeine antitussive agents versus placebo in symptomatic treatme

→ Coughs, regardless of etiology.

CRD42020201054 Effectiveness of paracetamol associated with codeine compared to paracetamol wit

→ The removal of third molars is a common practice i

CRD42023373868 The efficacy of codeine antitussive agents versus placebo in symptomatic treatme

→ Adults subjects and Children (>1 year old) with

CRD42023454183 Evaluating Pharmacological Interventions for Diabetic Neuropathy: A Network Meta

→ Pharmacological interventions used to manage diabe

CRD42023474614 Opioid Prescribing In Otolaryngology, a systematic review and meta-analysis

→ Opioid prescribing and consumption in otolaryngolo

CRD42023492183 Effectiveness of diacetylmorphine for opioid agonist treatment: A systematic rev

→ Opioid use disorder/opioid dependence. Opioid agon

CRD42023493615 Efficacy and safety of different oral opioids in postoperative pain management a

→ Total knee and hip arthroplasties are common proce

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables