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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Colchicine

Open on HERB 2.0 ↗

139

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Colchicine

COVID-19 12 Pharmacokinetics 10 Healthy 8 Coronary Artery Disease 7 Gout 5 Acute Coronary Syndrome 4 COVID19 4 COVID-19. 3 Atrial Fibrillation 3 Atrial fibrillation is a serious arrhythmia that can endange 2 HEART FAILURE 2 Pericarditis|Recurrence 2

📋 Sample Trials

NCT00984009

A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice

Completed · Phase 1

NCT00004748

Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis

Completed · Phase 3

NCT00128414

Study of Colchicine to Treat and Prevent Recurrent Pericarditis (First Episode)

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42015017733

Colchicine for prevention of cardiovascular events [Cochrane Protocol]

The Cochrane Heart Group

CRD42015024647

Colchicine for children with pericarditis: a systematic review of case-series and case-reports

Recurrent episodes of pericarditis can occur in up to a third of affected people

CRD42015025336

Colchicine for knee osteoarthritis

Osteoarthritis involving the knee.

📚 Sample References

PMID 22632542

Differential effects of colchicine in blood mononuclear cells of patients with Behçet disease in relation to colchicine responsiveness

Br J Dermatol · 2012

PMID 24720919

Anti-inflammatory treatment with colchicine in stable chronic heart failure: a prospective, randomized study

JACC Heart Fail · 2014

PMID 23040570

Colchicine for prevention of early atrial fibrillation recurrence after pulmonary vein isolation: a randomized controlled study

J Am Coll Cardiol · 2012

⚗️ All Ingredient data fields for Colchicine

⚗️ Identity

Name

Colchicine

Aliases / Synonyms

64-86-8; Colchisol; Colchicinum; Colchicin; Colchicina; Colchineos; Condylon; Colcin; Colsaloid

🧪 Chemistry

Molecular Weight

399.4430

LogP

2.8716

Drug-likeness

0.833

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Isomeric SMILES

CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

InChIKey

IAKHMKGGTNLKSZ-INIZCTEOSA-N

InChI

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

🔗 External References

HERB DB

HBIN021260 ↗

PubChem CID

6167 ↗

CAS Number

64-86-8 ↗

NPASS

NPC226941

HIT

C1250

SymMap

1348

TCMID

3911

TCM-ID

5537

🔍 Raw view — every non-empty column on this row (32 fields)

name

Colchicine

common names

64-86-8; Colchisol; Colchicinum; Colchicin; Colchicina; Colchineos; Condylon; Colcin; Colsaloid

herb ingredient id

HBIN021260

canonical smiles

CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

isomeric smiles

CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

inchi

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

inchikey

IAKHMKGGTNLKSZ-INIZCTEOSA-N

mol wt

399.4430

num h acceptors

num h donors

mol logp

2.8716

num rotatable bonds

drug likeness

0.833

cas id

64-86-8

symmap mol id

1348

tcmid ingredient id

3911

tcm id ingredient id

5537

pubchem cid

6167

npass id

NPC226941

hit id

C1250

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Amyotrophic Lateral Sclerosis

Myocardial Infarction

syndrome

Pericarditis

syndrome

Familial Mediterranean Fever

syndrome

Postpericardiotomy Syndrome

phenotype

Essential Hypertension

syndrome

Fibrosis, Liver

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00984009 A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice

→ Pharmacokinetics

NCT00004748 Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis

→ Liver Cirrhosis, Biliary

NCT00128414 Study of Colchicine to Treat and Prevent Recurrent Pericarditis (First Episode)

→ Pericarditis|Recurrence

NCT00128427 Study of Colchicine to Prevent the Postpericardiotomy Syndrome

→ Postpericardiotomy Syndrome

NCT00128453 Study of Colchicine to Treat Acute Pericarditis and Prevent Recurrences

→ Pericarditis

NCT00179413 Study of Long-term Peg Intron vs. Colchicine in Non-responders.

→ Hepatitis C Virus|Advanced Fibrosis|Cirrhosis

NCT00235079 Study of Colchicine to Treat and Prevent Recurrent Pericarditis After Failure of

→ Pericarditis|Recurrence

NCT00700297 Colchicine Randomized Double-Blind Controlled Crossover Study in Behcet's Diseas

→ Behcet's Syndrome

NCT00754819 Targeting Inflammation in Acute Coronary Syndrome Using Colchicine

→ Acute Coronary Syndrome

NCT00960193 Drug-Food Interaction Study of Seville Orange Juice and Colchicine

→ Healthy

NCT00960323 Drug-Drug Interaction Study Between Colchicine and Atorvastatin

→ Healthy

NCT00983216 Drug-Drug Interaction Study Between Colchicine and Ketoconazole

→ Pharmacokinetics

📊 Meta-Analyses

12 · systematic review

CRD42015017733 Colchicine for prevention of cardiovascular events [Cochrane Protocol]

→ The Cochrane Heart Group

CRD42015024647 Colchicine for children with pericarditis: a systematic review of case-series an

→ Recurrent episodes of pericarditis can occur in up

CRD42015025336 Colchicine for knee osteoarthritis

→ Osteoarthritis involving the knee.

CRD42016046010 Colchicine prophylactic treatment for prevention of atrial fibrillation after ca

→ Atrial fibrillation post cardiac surgery, i.e. CAB

CRD42017067427 The efficacy and safety of anti-inflammatory biologics, disease-modifying anti-r

→ Osteoarthritis is the most common joint disorder,

CRD42018099696 Colchicine intoxication and colchicine-induced rhabdomyolysis associated with co

→ Colchicine is a spindle poison. It inhibits the fo

CRD42019139353 Colchicine for prevention of post-lung resection and cardiac procedure atrial fi

→ Current research shows that verification is a drug

CRD42019142599 Effectiveness of colchicine as a treatment for oral ulcers: a systematic review

CRD42020161727 Meta-analysis of colchicine on cardiovascular outcomes and all-cause mortality i

→ Gout is a crystal related arthropathy caused by th

CRD42020163534 Effect of Anakinra on Colchicine Resistant and Steroid Dependent Recurrent Peric

→ Recurrent Pericarditis: Pericarditis is an inflamm

CRD42020166270 Efficacy and Safety of Colchicine after acute coronary syndrome, systematic revi

→ Acute coronary syndrome

CRD42020170251 Efficacy and Safety of Colchicine after Myocardial Infarction

→ Inflammation appears to play an important role in

📚 PubMed References

12 · cited research

PMID 22632542 Differential effects of colchicine in blood mononuclear cells of patients with B

Br J Dermatol

PMID 24720919 Anti-inflammatory treatment with colchicine in stable chronic heart failure: a p

JACC Heart Fail

PMID 23040570 Colchicine for prevention of early atrial fibrillation recurrence after pulmonar

J Am Coll Cardiol

PMID 27129183 Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to supp

Clin Sci (Lond)

PMID 21689407 Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-ba

J Biomed Sci

PMID 25362043 AMP-activated protein kinase suppresses urate crystal-induced inflammation and t

Ann Rheum Dis

PMID 23478658 Macrophage migration inhibitory factor induces contractile and mitochondria dysf

Crit Care Med

PMID 32733639 Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis th

Oxid Med Cell Longev

PMID 33232770 Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cell

Vascul Pharmacol

PMID 33968934 Colchicine Blocks Tubulin Heterodimer Recycling by Tubulin Cofactors TBCA, TBCB,

Front Cell Dev Biol

PMID 34425229 Colchicine protects against cartilage degeneration by inhibiting MMP13 expressio

Osteoarthritis Cartilage

PMID 34622440 Divergent impacts of tocilizumab and colchicine in COVID-19-associated coagulopa

Br J Haematol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables