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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Coumarins

Open on HERB 2.0 ↗

153

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Coumarins

Healthy 22 Atrial Fibrillation 20 Thromboembolism 7 Healthy Volunteers 5 Type 2 Diabetes Mellitus 3 Neoplasms 2 Stroke|Venous Thrombosis|Atrial Fibrillation|Atrial Flutter 2 Atrial Fibrillation|Stroke 2 Diabetes Mellitus, Type 2 2 Anticoagulation 2 Pulmonary Arterial Hypertension 1 Drug Therapy, Combination 1

📋 Sample Trials

NCT02254148

The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)

Completed · Phase 1

NCT04679948

A Study in Healthy People to Test Whether BI 730357 Influences the Amount of Caffeine, Warfarin, Omeprazole, and Midazolam in the Blood

Completed · Phase 1

NCT00007683

Warfarin and Antiplatelet Therapy in Chronic Heart Failure

Completed · Phase 3

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 33901456

Warfarin Induces Calcification of the Aortic Valve Through Extracellular Signal-regulated Kinase 1/2 and β-catenin Signaling

Ann Thorac Surg · 2021

⚗️ All Ingredient data fields for Coumarins

⚗️ Identity

Name

Coumarins

Aliases / Synonyms

warfarin; 81-81-2; Coumadin; Coumafene; Zoocoumarin; Coumafen; Brumolin; Coumefene; Kypfarin; Solfarin

🧪 Chemistry

Molecular Weight

308.3330

LogP

3.6096

Drug-likeness

0.748

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O

Isomeric SMILES

CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O

InChIKey

PJVWKTKQMONHTI-UHFFFAOYSA-N

InChI

InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3

🔗 External References

HERB DB

HBIN021614 ↗

PubChem CID

54678486 ↗

CAS Number

140679-94-3 ↗

NPASS

NPC2989

TCMID

34666

TCM-ID

1364

🔍 Raw view — every non-empty column on this row (30 fields)

name

Coumarins

common names

warfarin; 81-81-2; Coumadin; Coumafene; Zoocoumarin; Coumafen; Brumolin; Coumefene; Kypfarin; Solfarin

herb ingredient id

HBIN021614

canonical smiles

CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O

isomeric smiles

CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O

inchi

InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3

inchikey

PJVWKTKQMONHTI-UHFFFAOYSA-N

mol wt

308.3330

num h acceptors

num h donors

mol logp

3.6096

num rotatable bonds

drug likeness

0.748

cas id

140679-94-3

tcmid ingredient id

34666

tcm id ingredient id

1364

pubchem cid

54678486

npass id

NPC2989

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Blood Coagulation Disorders

Myocardial Infarction

📋 Clinical Trials

12 · subject of clinical study

NCT02254148 The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (C

→ Healthy

NCT04679948 A Study in Healthy People to Test Whether BI 730357 Influences the Amount of Caf

→ Healthy

NCT00007683 Warfarin and Antiplatelet Therapy in Chronic Heart Failure

→ Heart Failure

NCT00014352 Combination Chemotherapy Plus Warfarin in Treating Patients With Prostate Cancer

→ Prostate Cancer|Thromboembolism

NCT00024297 Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Cathet

→ Thromboembolism

NCT00027066 Warfarin Versus Aspirin Recurrent Stroke Study

→ Stroke

NCT00041938 Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial

→ Heart Disease|Stroke|Ischemic Heart Disease|Myocar

NCT00070655 Evaluating the Use of SR34006 Compared to Warfarin or Acenocoumarol in Patients

→ Atrial Fibrillation

NCT00091299 Warfarin and Vatalanib in Treating Patients With Advanced Solid Tumors

→ Unspecified Adult Solid Tumor, Protocol Specific

NCT00157651 Access II - Trial of Warfarin to Prevent Malfunction of Haemodialysis Catheters

→ End Stage Renal Disease|Thrombosis|Bleeding

NCT00291330 Efficacy and Safety of Dabigatran Compared to Warfarin for 6 Month Treatment of

→ Thromboembolism

NCT00403767 An Efficacy and Safety Study of Rivaroxaban With Warfarin for the Prevention of

→ Atrial Fibrillation|Stroke|Embolism

📚 PubMed References

1 · cited research

PMID 33901456 Warfarin Induces Calcification of the Aortic Valve Through Extracellular Signal-

Ann Thorac Surg

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables