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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Curcumin

Open on HERB 2.0 ↗

121

Clinical Trials

186

Meta-Analyses

199

PubMed References

Top Conditions Studied with Curcumin

Prostate Cancer 4 Healthy 4 Periodontitis 3 Colorectal Cancer 3 Breast Cancer 3 People with different diseases 3 Familial Adenomatous Polyposis 2 Oral submucous fibrosis (OSF) is an insidious and chronic or 2 Bioavailability 2 Knee Osteoarthritis 2 Alzheimer's Disease 2 Irritable Bowel Syndrome 2

📋 Sample Trials

NCT00164749

A Pilot Study of Curcumin and Ginkgo for Treating Alzheimer's Disease

Completed · Phase 1|Phase 2

NCT03066791

Turmeric and Curcumin on Sebum Production

Completed

NCT01831193

Effect of Oral Supplementation With Curcumin (Turmeric) in Patients With Proteinuric Chronic Kidney Disease

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42020166300

“Comparative Efficiency Of Ginger Extract Gel With And Without Curcumin Gel For Management Of Homogeneous Leukoplakia Evaluated By Salivary Malondialdehyde Level” (Biomarker)

Oral leukoplakia (OL) is the most frequent precancerous lesion of the oral cavit

CRD42022334940

Anticancer effects of gingerol, shogaol and curcumin in cervical cancer: A systemic review.

CRD42022323737

Arteannuin, fructus lycii extract and curcumin for uterine cervical carcinoma: A protocol for systematic review and meta-analysis

Cancer is a worldwide public health concern, with severe social and economic rep

📚 Sample References

PMID 25595578

Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis

Am J Obstet Gynecol · 2015

PMID 29807115

Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1

Cancer Lett · 2018

PMID 22258452

Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression

Cancer Res · 2012

⚗️ All Ingredient data fields for Curcumin

⚗️ Identity

Name

Curcumin

Aliases / Synonyms

458-37-7; Diferuloylmethane; Natural yellow 3; Kacha haldi; Indian saffron; Curcuma; Gelbwurz; Haldar; Curcumin I

🧪 Chemistry

Molecular Weight

368.3850

LogP

3.3699

Drug-likeness

0.548

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

Isomeric SMILES

COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

InChIKey

VFLDPWHFBUODDF-FCXRPNKRSA-N

InChI

InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

🔗 External References

HERB DB

HBIN021985 ↗

PubChem CID

969516 ↗

CAS Number

485-37-7 ↗

NPASS

NPC160900

HIT

C0739

TCMID

4397

TCMSP

MOL000090; MOL002581

TCM-ID

5362

🔍 Raw view — every non-empty column on this row (32 fields)

name

Curcumin

common names

458-37-7; Diferuloylmethane; Natural yellow 3; Kacha haldi; Indian saffron; Curcuma; Gelbwurz; Haldar; Curcumin I

herb ingredient id

HBIN021985

canonical smiles

COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

isomeric smiles

COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

inchi

InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

inchikey

VFLDPWHFBUODDF-FCXRPNKRSA-N

mol wt

368.3850

num h acceptors

num h donors

mol logp

3.3699

num rotatable bonds

drug likeness

0.548

cas id

485-37-7

tcmid ingredient id

4397

tcmsp ingredient id

MOL000090; MOL002581

tcm id ingredient id

5362

pubchem cid

969516

npass id

NPC160900

hit id

C0739

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Alzheimer'S Disease

syndrome

Amyotrophic Lateral Sclerosis

Inflammatory Bowel Diseases

group

Irritable Bowel Syndrome

Polycystic Kidney, Autosomal Dominant

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00164749 A Pilot Study of Curcumin and Ginkgo for Treating Alzheimer's Disease

→ Alzheimer's Disease

NCT03066791 Turmeric and Curcumin on Sebum Production

→ Inflammation; Skin

NCT01831193 Effect of Oral Supplementation With Curcumin (Turmeric) in Patients With Protein

→ Proteinuria

NCT03845322 Curcumin/Turmeric as a Treatment for Patients With Subdural Hematomas Recurrence

→ Hematoma, Subdural, Chronic

NCT03980509 A "Window Trial" on Curcumin for Invasive Breast Cancer Primary Tumors

→ Breast Cancer

NCT00027495 Curcumin for the Prevention of Colon Cancer

→ Colorectal Cancer

NCT00094445 Trial of Curcumin in Advanced Pancreatic Cancer

→ Pancreatic Neoplasms|Adenocarcinoma

NCT00099710 Curcumin in Patients With Mild to Moderate Alzheimer's Disease

→ Alzheimer's Disease

NCT00113841 Curcumin (Diferuloylmethane Derivative) With or Without Bioperine in Patients Wi

→ Multiple Myeloma

NCT00181662 Pharmacokinetics of Curcumin in Healthy Volunteers

→ Healthy

NCT00192842 Gemcitabine With Curcumin for Pancreatic Cancer

→ Pancreatic Cancer

NCT00365209 Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplasti

→ Healthy, no Evidence of Disease|Tobacco Use Disord

📊 Meta-Analyses

12 · systematic review

CRD42020166300 “Comparative Efficiency Of Ginger Extract Gel With And Without Curcumin Gel For

→ Oral leukoplakia (OL) is the most frequent precanc

CRD42022334940 Anticancer effects of gingerol, shogaol and curcumin in cervical cancer: A syste

CRD42022323737 Arteannuin, fructus lycii extract and curcumin for uterine cervical carcinoma: A

→ Cancer is a worldwide public health concern, with

CRD42019148682 Bioavailability of curcumin is a determinant of its anti-inflammatory potential

→ Inflammation is a key biological risk factor under

CRD42021237458 The action of curcumin against damage resulting from stroke: a systematic review

CRD42021279230 Combination of Curcumin and Photodynamic Therapy Based on the Use of Red Light o

CRD42015019039 The effects of curcumin on musculoskeletal pain: a systematic review protocol

→ Curcuma longa (turmeric) from the Ginger family (Z

CRD42015025056 Clinical effects of curcumin on depression: a systematic review and meta-analysi

→ Depression or depressive disorder.

CRD42015025203 The role of curcumin in patients with major depressive disorders: a mini meta-an

→ Major Depressive Disorders (MDD) is a serious clin

CRD42015026890 Efficacy and safety of oral pharmacologic interventions comparable with curcumin

→ Knee OA is a common and progressive joint disease

CRD42016035384 Can curcumin effectively improve glycemic control in type 2 diabetic patients? A

→ Diabetes is a rapidly growing contributor to globa

CRD42016036778 Effects of curcumin on blood lipid levels: a systematic review and meta-analysis

→ Several pharmacological studies have reported that

📚 PubMed References

12 · cited research

PMID 25595578 Curcumin ameliorates high glucose-induced neural tube defects by suppressing cel

Am J Obstet Gynecol

PMID 29807115 Curcumin suppresses oncogenicity of human colon cancer cells by covalently modif

Cancer Lett

PMID 22258452 Targeting pioneering factor and hormone receptor cooperative pathways to suppres

Cancer Res

PMID 21237271 Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 induci

Pharmacol Res

PMID 26609559 Curcumin inhibits activation of TRPM2 channels in rat hepatocytes

Redox Biol

PMID 27077805 Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic ste

Cell Death Dis

PMID 32033136 Highlighting Curcumin-Induced Crosstalk between Autophagy and Apoptosis as Suppo

Cells

PMID 32012894 Low Dosed Curcumin Combined with Visible Light Exposure Inhibits Renal Cell Carc

Cancers (Basel)

PMID 31843707 Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy

Neurobiol Dis

PMID 31816386 Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mito

Free Radic Biol Med

PMID 30951849 Curcumin restores innate immune Alzheimer's disease risk gene expression to amel

Neurobiol Dis

PMID 30934902 Curcumin and o-Vanillin Exhibit Evidence of Senolytic Activity in Human IVD Cell

J Clin Med

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables