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Gene Target
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Disease
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
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⚗️ Ingredient

Cyclosporin a

Open on HERB 2.0 ↗
8
Clinical Trials
0
Meta-Analyses
0
PubMed References
Top Conditions Studied with Cyclosporin a
Atopic Dermatitis 1 Aplastic Anemia 1 Sjogren's Syndrome|Dry Eye|Ocular Surface Disease 1 Non-severe Aplastic Anemia 1 Myocardial Injury|Cardiac Surgery 1 Management of Punctal Stenosis 1 Healthy 1 Dry Eye 1
📋 Sample Trials
NCT05771012
Topical Cyclosporin A 0.05% Eye Drops for Management of Symptomatic Acquired Punctal Stenosis. A Prospective, Controlled Clinical Study.
Completed
NCT05692843
Optimization of Cyclosporin in Atopic Dermatitis Through Multiomic Predictive Models of Treatment Response
Recruiting · Phase 4
NCT06013436
AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye
Completed
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
None linked yet.
⚗️ All Ingredient data fields for Cyclosporin a
⚗️ Identity
Name
Cyclosporin a
Aliases / Synonyms
cyclosporine; Ciclosporin; Cyclosporin; 59865-13-3; Sandimmune; Cyclosporine A; Neoral; Sandimmun; Ramihyphin A
🧪 Chemistry
Molecular Weight
1202.6350
LogP
3.2690
Drug-likeness
0.148
H-Bond Acceptors
12
H-Bond Donors
5
Rotatable Bonds
15
🔬 Structures
Canonical SMILES
CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
Isomeric SMILES
CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
InChIKey
PMATZTZNYRCHOR-CGLBZJNRSA-N
InChI
InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
🔗 External References
HERB DB
HBIN022374 ↗
PubChem CID
5284373 ↗
TCM-ID
16673
🔍 Raw view — every non-empty column on this row (27 fields)
name
Cyclosporin a
common names
cyclosporine; Ciclosporin; Cyclosporin; 59865-13-3; Sandimmune; Cyclosporine A; Neoral; Sandimmun; Ramihyphin A
herb ingredient id
HBIN022374
canonical smiles
CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
isomeric smiles
CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
inchi
InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
inchikey
PMATZTZNYRCHOR-CGLBZJNRSA-N
mol wt
1202.6350
num h acceptors
12
num h donors
5
mol logp
3.2690
num rotatable bonds
15
drug likeness
0.148
tcm id ingredient id
16673
pubchem cid
5284373

🏥 Linked Health Topics

2 · diseases via target pathways
Aplastic Anemia
syndrome
Atopic Dermatitis
disease

📋 Clinical Trials

8 · subject of clinical study
NCT05771012 Topical Cyclosporin A 0.05% Eye Drops for Management of Symptomatic Acquired Pun
→ Management of Punctal Stenosis
NCT05692843 Optimization of Cyclosporin in Atopic Dermatitis Through Multiomic Predictive Mo
→ Atopic Dermatitis
NCT06013436 AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Pa
→ Sjogren's Syndrome|Dry Eye|Ocular Surface Disease
NCT05691764 Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischem
→ Myocardial Injury|Cardiac Surgery
NCT05797623 Safety and Effectiveness of Trappa Ethanolamine Tablets Combined With Ciclospori
→ Non-severe Aplastic Anemia
NCT05745701 A Drug-Drug Interaction Study to Examine the Impact of Itraconazole and Cyclospo
→ Healthy
NCT06043908 The Effect of 0.05% CsA Eye Drops on Post-refractive Surgery Dry Eye
→ Dry Eye
NCT06004752 Efficacy and Safety of CsA+AVA in the Treatment of NSAA in the Elderly
→ Aplastic Anemia
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables