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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Cystisine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Cystisine

Smoking Cessation 6 Tobacco Use Disorder|Alcohol Use Disorder|Smoking Cessation 1 Smoking is a major cause of morbidity and mortality worldwid 1 Smoking is a chronic disease that generates 8 million premat 1

📋 Sample Trials

NCT02957786

Cytisine Versus Varenicline for Smoking Cessation

Completed · Phase 3

NCT03268343

A Study in Healthy Volunteers to Investigate the Effect of Food on the Bioavailability of Cytisine

Completed · Phase 1

NCT03509948

A Study in Healthy Smokers to Investigate the Effect of Food on the Bioavailability of Cytisine in a New Formulation

Completed · Phase 1

📊 Sample Meta-Analyses

CRD42021266448

The efficacy, safety and cost effectiveness of Cytisine for smoking cessation: a systematic review and meta-analysis

Smoking is a major cause of morbidity and mortality worldwide. Five million adul

CRD42022296780

Evaluation of the effectiveness of cytisine for the treatment of smoking cessation: a systematic review and meta-analysis

Smoking is a chronic disease that generates 8 million premature deaths annually

CRD42012003455

Cytisine for smoking cessation

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Cystisine

⚗️ Identity

Name

Cystisine

Aliases / Synonyms

CYTISINE; 485-35-8; Baptitoxine; Sophorine; Cytisinicline; Baptitoxin; Laburnin; Cytiton; Tabex; Ulexine

🧪 Chemistry

Molecular Weight

190.2460

LogP

0.5550

Drug-likeness

0.648

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

C1C2CNCC1C3=CC=CC(=O)N3C2

Isomeric SMILES

C1[C@H]2CNC[C@@H]1C3=CC=CC(=O)N3C2

InChIKey

ANJTVLIZGCUXLD-DTWKUNHWSA-N

InChI

InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1

🔗 External References

HERB DB

HBIN022517 ↗

PubChem CID

10235 ↗

NPASS

NPC77890

HIT

C1276

TCM-ID

14724

🔍 Raw view — every non-empty column on this row (29 fields)

name

Cystisine

common names

CYTISINE; 485-35-8; Baptitoxine; Sophorine; Cytisinicline; Baptitoxin; Laburnin; Cytiton; Tabex; Ulexine

herb ingredient id

HBIN022517

canonical smiles

C1C2CNCC1C3=CC=CC(=O)N3C2

isomeric smiles

C1[C@H]2CNC[C@@H]1C3=CC=CC(=O)N3C2

inchi

InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9+/m0/s1

inchikey

ANJTVLIZGCUXLD-DTWKUNHWSA-N

mol wt

190.2460

num h acceptors

num h donors

mol logp

0.5550

num rotatable bonds

drug likeness

0.648

tcm id ingredient id

14724

pubchem cid

10235

npass id

NPC77890

hit id

C1276

📋 Clinical Trials

7 · subject of clinical study

NCT02957786 Cytisine Versus Varenicline for Smoking Cessation

→ Smoking Cessation

NCT03268343 A Study in Healthy Volunteers to Investigate the Effect of Food on the Bioavaila

→ Smoking Cessation

NCT03509948 A Study in Healthy Smokers to Investigate the Effect of Food on the Bioavailabil

→ Smoking Cessation

NCT03709823 Trial of Cytisine in Adult Smokers

→ Smoking Cessation

NCT03848208 A Single Dose-escalation Study of Cytisine in Adult Smokers

→ Smoking Cessation

NCT04015414 Varenicline Versus Cytisine for Smoking Cessation in Primary Care Setting

→ Smoking Cessation

NCT05729243 Cytisine for Smoking Cessation

→ Tobacco Use Disorder|Alcohol Use Disorder|Smoking

📊 Meta-Analyses

3 · systematic review

CRD42021266448 The efficacy, safety and cost effectiveness of Cytisine for smoking cessation: a

→ Smoking is a major cause of morbidity and mortalit

CRD42022296780 Evaluation of the effectiveness of cytisine for the treatment of smoking cessati

→ Smoking is a chronic disease that generates 8 mill

CRD42012003455 Cytisine for smoking cessation

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables