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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Digitoxin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Digitoxin

Cystic Fibrosis 1

📋 Sample Trials

NCT00782288

Phase II Study of Digitoxin to Treat Cystic Fibrosis

Completed · Phase 2

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 28916653

YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation

Cancer Res · 2017

PMID 28688145

Therapeutic concentrations of digitoxin inhibit endothelial focal adhesion kinase and angiogenesis induced by different growth factors

Br J Pharmacol · 2017

PMID 24104877

Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides

Cardiovasc Res · 2014

⚗️ All Ingredient data fields for Digitoxin

⚗️ Identity

Name

Digitoxin

Aliases / Synonyms

71-63-6; Digitoxoside; Crystodigin; Digitoxinum; Unidigin; Digitophyllin; Carditoxin; Cristapurat; Digitoksin

🧪 Chemistry

Molecular Weight

764.9500

LogP

3.2473

Drug-likeness

0.188

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CCC7(C6(CCC7C8=CC(=O)OC8)O)C)C)C)C)O)O

Isomeric SMILES

C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5CC[C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)C)C)C)O)O

InChIKey

WDJUZGPOPHTGOT-XUDUSOBPSA-N

InChI

InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27+,28-,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1

🔗 External References

HERB DB

HBIN023784 ↗

PubChem CID

441207 ↗

NPASS

NPC72260

HIT

C0019

TCMID

5525

TCM-ID

4919

🔍 Raw view — every non-empty column on this row (30 fields)

name

Digitoxin

common names

71-63-6; Digitoxoside; Crystodigin; Digitoxinum; Unidigin; Digitophyllin; Carditoxin; Cristapurat; Digitoksin

herb ingredient id

HBIN023784

canonical smiles

CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CCC7(C6(CCC7C8=CC(=O)OC8)O)C)C)C)C)O)O

isomeric smiles

C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5CC[C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)C)C)C)O)O

inchi

inchikey

WDJUZGPOPHTGOT-XUDUSOBPSA-N

mol wt

764.9500

num h acceptors

num h donors

mol logp

3.2473

num rotatable bonds

drug likeness

0.188

tcmid ingredient id

5525

tcm id ingredient id

4919

pubchem cid

441207

npass id

NPC72260

hit id

C0019

🏥 Linked Health Topics

1 · diseases via target pathways

Cystic Fibrosis

syndrome

📋 Clinical Trials

1 · subject of clinical study

NCT00782288 Phase II Study of Digitoxin to Treat Cystic Fibrosis

→ Cystic Fibrosis

📚 PubMed References

5 · cited research

PMID 28916653 YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the

Cancer Res

PMID 28688145 Therapeutic concentrations of digitoxin inhibit endothelial focal adhesion kinas

Br J Pharmacol

PMID 24104877 Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiot

Cardiovasc Res

PMID 32468057 Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arr

Int J Oncol

PMID 34717917 Digitoxin promotes apoptosis and inhibits proliferation and migration by reducin

Chem Biol Interact

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables