Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Digoxin

Open on HERB 2.0 ↗

106

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Digoxin

Healthy 21 Healthy Volunteers 7 Diabetes|Healthy 3 Healthy Volunteer 3 Atrial Fibrillation 3 Heart Failure 3 Drug Interaction Potentiation 2 Type 2 Diabetes Mellitus 2 Neoplasms 2 Diabetes Mellitus, Type 2 2 Rheumatoid Arthritis 2 Prostate Cancer 2

📋 Sample Trials

NCT03856970

Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers

Completed · Phase 1

NCT01517399

Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects

Completed · Phase 1

NCT02254148

The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)

Completed · Phase 1

📊 Sample Meta-Analyses

CRD42016052935

Digoxin versus placebo, no intervention, or other medical interventions for atrial fibrillation and atrial flutter: a protocol for a systematic review with meta-analysis and trial sequential analysis

CRD42019152063

In adults with heart valve disease without concomitant heart failure, what is the clinical and cost effectiveness of alpha-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin-II receptor blockers (ARBs), beta blockers, calcium channel blockers, digoxin, diuretics, statins and nitrates to improve clinical outcome?

Diagnosed heart valve disease in adults aged 18 years and over: Aortic (includin

CRD42021226885

Association between digoxin therapy and incidence, cancer-specific mortality of prostate cancer: a systematic review and meta-analysis

The usage of digoxin therapy for prostate cancer.

📚 Sample References

PMID 34704235

Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion

Neurosci Bull · 2022

PMID 34853001

Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis

Ann Rheum Dis · 2022

⚗️ All Ingredient data fields for Digoxin

⚗️ Identity

Name

Digoxin

Aliases / Synonyms

20830-75-5; Lanoxin; 12beta-Hydroxydigitoxin; Rougoxin; Digacin; Dilanacin; Dynamos; Vanoxin; Fargoxin

🧪 Chemistry

Molecular Weight

780.9490

LogP

2.2181

Drug-likeness

0.162

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)O

Isomeric SMILES

C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O

InChIKey

LTMHDMANZUZIPE-PUGKRICDSA-N

InChI

InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1

🔗 External References

HERB DB

HBIN023789 ↗

PubChem CID

2724385 ↗

NPASS

NPC173555

HIT

C0020

TCMID

5532

TCM-ID

4918

🔍 Raw view — every non-empty column on this row (30 fields)

name

Digoxin

common names

20830-75-5; Lanoxin; 12beta-Hydroxydigitoxin; Rougoxin; Digacin; Dilanacin; Dynamos; Vanoxin; Fargoxin

herb ingredient id

HBIN023789

canonical smiles

CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)O

isomeric smiles

C[C@@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@H](O[C@H](C[C@@H]2O)O[C@@H]3[C@H](O[C@H](C[C@@H]3O)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5C[C@H]([C@]7([C@@]6(CC[C@@H]7C8=CC(=O)OC8)O)C)O)C)C)C)O)O

inchi

inchikey

LTMHDMANZUZIPE-PUGKRICDSA-N

mol wt

780.9490

num h acceptors

num h donors

mol logp

2.2181

num rotatable bonds

drug likeness

0.162

tcmid ingredient id

5532

tcm id ingredient id

4918

pubchem cid

2724385

npass id

NPC173555

hit id

C0020

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Essential Hypertension

syndrome

Congenital Heart Disease

group

Acute Heart Failure

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT03856970 Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contrace

→ Healthy Volunteers

NCT01517399 Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin,

→ Solid Tumors

NCT02254148 The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (C

→ Healthy

NCT02685462 Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitor

→ Healthy

NCT03131973 Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, M

→ Rheumatoid Arthritis

NCT04425902 Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metop

→ HIV Infections

NCT00904176 Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digo

→ Type 2 Diabetes Mellitus

NCT02783040 Interaction of BI 425809 With Midazolam, Warfarin, Omeprazole and Digoxin

→ Healthy

NCT03363815 A Study to Evaluate the Effect of Multiple Doses of CC-90001 on the Pharmacokine

→ Heathy Volunteer

NCT00006330 Pharmacokinetic and Pharmacodynamic Interaction Study of Digoxin and Hawthorn

→ Heart Diseases

NCT00712465 An Interaction Study With Digoxin and AZD1305

→ Atrial Fibrillation

NCT00723424 Drug Interaction Study - Effect of AZD5672 on the Pharmacokinetics of Digoxin

→ Healthy Volunteers|Pharmacokinetics

📊 Meta-Analyses

12 · systematic review

CRD42016052935 Digoxin versus placebo, no intervention, or other medical interventions for atri

CRD42019152063 In adults with heart valve disease without concomitant heart failure, what is th

→ Diagnosed heart valve disease in adults aged 18 ye

CRD42021226885 Association between digoxin therapy and incidence, cancer-specific mortality of

→ The usage of digoxin therapy for prostate cancer.

CRD42021237536 Is digoxin use for cardiovascular disease associated with risk of prostate cance

→ Digoxin is a commonly used medication for heart fa

CRD42022365996 Population Pharmacokinetics of Digoxin in Elderly Patients: A Systematic Review

→ To study the literature available about population

CRD42013006258 Effectiveness and safety of digoxin on chronic heart failure: meta analysis of c

→ Heart failure is a condition in which the heart is

CRD42014013492 Outcomes of Digoxin treatment in right heart failure: a systematic review

→ Heart Failure, Digoxin, Mortality

CRD42018105300 Population pharmacokinetics of digoxin in adults and elderly: a systematic revie

→ Pharmacokinetics

CRD42022321459 The safety of digoxin based on therapeutic drug monitoring: a systematic review

→ This study will investigate comparisons of the saf

CRD42022325321 Effect of digoxin on mortality in patients with atrial fibrillation and heart fa

→ We will study the effect of digoxin use in patient

CRD42020222258 The effect of digoxin use on mortality and hospitalization in Patients with Atri

→ Atrial fibrillation(AF) is a common cardiac rhythm

CRD42021214181 Digoxin and all-cause mortality in Patients with Heart Failure with Preserved Ej

→ Clinical efficacy and effectiveness of digoxin in

📚 PubMed References

2 · cited research

PMID 34704235 Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Mod

Neurosci Bull

PMID 34853001 Digoxin targets low density lipoprotein receptor-related protein 4 and protects

Ann Rheum Dis

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables