Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Diosmetin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

📋 Sample Trials

None linked yet.

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 30825187

Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclitaxel in non-small cell lung cancer cells via Nrf2 inhibition

Br J Pharmacol · 2019

PMID 31833613

Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes through regulating the Akt and NF-κB signaling pathways

Phytother Res · 2020

PMID 33449987

Diosmetin attenuates metabolic syndrome and left ventricular alterations via the suppression of angiotensin II/AT 1 receptor/gp91 phox/p-NF-κB protein expression in high-fat diet fed rats

Food Funct · 2021

⚗️ All Ingredient data fields for Diosmetin

⚗️ Identity

Name

Diosmetin

Aliases / Synonyms

520-34-3; 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one; Luteolin 4'-methyl ether; 4'-Methylluteolin; Salinigricoflavonol; Diosmetine; Pillon; 3',5,7-trihydroxy-4'-methoxyflavone; 5,7,3'-Trihydroxy-4'-methoxyflavone

🧪 Chemistry

Molecular Weight

300.2660

LogP

2.5854

Drug-likeness

0.672

Oral Bioavailability

31.1380

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

Isomeric SMILES

COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

InChIKey

MBNGWHIJMBWFHU-UHFFFAOYSA-N

InChI

InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3

🔗 External References

HERB DB

HBIN024184 ↗

PubChem CID

5281612 ↗

CAS Number

520-34-3 ↗

NPASS

NPC52005

HIT

C0026

SymMap

5049

TCMID

6451; 21760

TCMSP

MOL002881

TCM-ID

12601

🔍 Raw view — every non-empty column on this row (36 fields)

name

Diosmetin

common names

herb ingredient id

HBIN024184

canonical smiles

COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

isomeric smiles

COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

inchi

InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3

inchikey

MBNGWHIJMBWFHU-UHFFFAOYSA-N

mol wt

300.2660

num h acceptors

num h donors

mol logp

2.5854

num rotatable bonds

drug likeness

0.672

ob score

31.1380

cas id

520-34-3

symmap mol id

5049

tcmid ingredient id

6451; 21760

tcmsp ingredient id

MOL002881

tcm id ingredient id

12601

pubchem cid

5281612

npass id

NPC52005

hit id

C0026

tcmsp mol id

MOL002881

tcmsp molecule id

2881

🌿 Related Herbs

1 · contains this compound

Ephedra

Ma Huang

🧬 Gene / Protein Targets

10 · directly binds these targets

NCOA1

Gene NCOA1

NCOA2

Gene NCOA2

Prostaglandin G/H synthase 1

Prostaglandin G/H synthase 2

Heat shock protein HSP 90

Dipeptidyl peptidase IV

Trypsin-1

Nitric oxide synthase, inducible

mRNA of PKA Catalytic Subunit C-alpha

Calmodulin

🏥 Linked Health Topics

30 · diseases via target pathways

Cardiovascular disease, unspecified

disease

Chronic inflammatory diseases

Carpal Tunnel Syndrome

Myocardial Infarction

syndrome

Peutz-Jeghers Syndrome

syndrome

Malignant Mesothelioma

Rheumatoid arthritis, unspecified

Inflammatory diseases

disease

Bladder cancer

disease

Abdominal aortic aneurysm

disease

Adenomatous polyposis

disease

Carcinoma in situ, unspecified

disease

Dysmenorrhea, unspecified

disease

Genitourinary tumors

disease

Gestational hypertension

disease

Oropharyngeal squamous cell carcinoma

disease

📚 PubMed References

11 · cited research

PMID 30825187 Diosmetin induces apoptosis and enhances the chemotherapeutic efficacy of paclit

Br J Pharmacol

PMID 31833613 Diosmetin exhibits anti-proliferative and anti-inflammatory effects on TNF-α-sti

Phytother Res

PMID 33449987 Diosmetin attenuates metabolic syndrome and left ventricular alterations via the

Food Funct

PMID 34091150 Diosmetin ameliorate type 2 diabetic mellitus by up-regulating Corynebacterium g

Phytomedicine

PMID 34262136 Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflamm

Acta Pharmacol Sin

PMID 34573119 Diosmetin Ameliorates Vascular Dysfunction and Remodeling by Modulation of Nrf2/

Antioxidants (Basel)

PMID 34922636 Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3/c-Myc

Biol Res

PMID 35242278 Diosmetin Protects against Cardiac Hypertrophy via p62/Keap1/Nrf2 Signaling Path

Oxid Med Cell Longev

PMID 35481411 Diosmetin attenuates oxidative stress-induced damage to lens epithelial cells vi

Bioengineered

PMID 35684047 Diosmetin Targeted at Peroxisome Proliferator-Activated Receptor Gamma Alleviate

Nutrients

PMID 35955819 Lobelia chinensis Extract and Its Active Compound, Diosmetin, Improve Atopic Der

Int J Mol Sci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables