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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Diosmin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Diosmin

Chronic Venous Disease of Lower Limbs 1 Bioequivalence 1 insufficiency venous 1 Venous Insufficiency 1 Metabolic Syndrome and Diabetic Neuropathy 1 Infertility 1 Deep Vein Thrombosis|Postthrombotic Syndrome 1

📋 Sample Trials

NCT01532882

Efficacy and Safety of Diosmin 600mg Versus Placebo on Painful Symptomatology in Patients With Chronic Venous Disease of Lower Limbs

Completed · Phase 3

NCT02134249

Diosmin Versus Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome

Completed · Phase 2|Phase 3

NCT03413618

Rivaroxaban With Diosmin in Long-term Treatment of Deep Vein Thrombosis

Completed · Phase 4

📊 Sample Meta-Analyses

CRD42017078018

Systematic review and meta-analysis of efficacy of diosmin and hesperidin versus aminftones in inflammatory mediators levels decrease and pain scale in chronic venous insufficiency treatment.

insufficiency venous

📚 Sample References

PMID 26361726

Diosmin downregulates the expression of T cell receptors, pro-inflammatory cytokines and NF-κB activation against LPS-induced acute lung injury in mice

Pharmacol Res · 2015

PMID 33302042

Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in atopic dermatitis

Phytomedicine · 2021

PMID 33744325

Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity

Life Sci · 2021

⚗️ All Ingredient data fields for Diosmin

⚗️ Identity

Name

Diosmin

Aliases / Synonyms

520-27-4; Barosmin; Diosimin; Flebosten; Venosmine; Diosmil; Diosmine; Daflon; Tovene

🧪 Chemistry

Molecular Weight

608.5490

LogP

-1.0897

Drug-likeness

0.159

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

Isomeric SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

InChIKey

GZSOSUNBTXMUFQ-YFAPSIMESA-N

InChI

InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

🔗 External References

HERB DB

HBIN024193 ↗

PubChem CID

5281613 ↗

NPASS

NPC209296

HIT

C0027

TCMID

6453

TCMSP

MOL005093

TCM-ID

4839

🔍 Raw view — every non-empty column on this row (31 fields)

name

Diosmin

common names

520-27-4; Barosmin; Diosimin; Flebosten; Venosmine; Diosmil; Diosmine; Daflon; Tovene

herb ingredient id

HBIN024193

canonical smiles

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

isomeric smiles

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

inchi

inchikey

GZSOSUNBTXMUFQ-YFAPSIMESA-N

mol wt

608.5490

num h acceptors

num h donors

mol logp

-1.0897

num rotatable bonds

drug likeness

0.159

tcmid ingredient id

6453

tcmsp ingredient id

MOL005093

tcm id ingredient id

4839

pubchem cid

5281613

npass id

NPC209296

hit id

C0027

🏥 Linked Health Topics

2 · diseases via target pathways

📋 Clinical Trials

6 · subject of clinical study

NCT01532882 Efficacy and Safety of Diosmin 600mg Versus Placebo on Painful Symptomatology in

→ Chronic Venous Disease of Lower Limbs

NCT02134249 Diosmin Versus Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome

→ Infertility

NCT03413618 Rivaroxaban With Diosmin in Long-term Treatment of Deep Vein Thrombosis

→ Deep Vein Thrombosis|Postthrombotic Syndrome

NCT03471910 Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in S

→ Venous Insufficiency

NCT05158192 Bioavailability of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to Ref

→ Bioequivalence

NCT05243238 Hesperidin and Diosmin Effect on Metabolic Syndrome

→ Metabolic Syndrome and Diabetic Neuropathy

📊 Meta-Analyses

1 · systematic review

CRD42017078018 Systematic review and meta-analysis of efficacy of diosmin and hesperidin versus

→ insufficiency venous

📚 PubMed References

7 · cited research

PMID 26361726 Diosmin downregulates the expression of T cell receptors, pro-inflammatory cytok

Pharmacol Res

PMID 33302042 Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in

Phytomedicine

PMID 33744325 Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanis

Life Sci

PMID 33802633 Diosmin Mitigates Cyclophosphamide Induced Premature Ovarian Insufficiency in Ra

Int J Mol Sci

PMID 34638796 Diosmin Inhibits Glioblastoma Growth through Inhibition of Autophagic Flux

Int J Mol Sci

PMID 34943101 Diosmin Alleviates Doxorubicin-Induced Liver Injury via Modulation of Oxidative

Antioxidants (Basel)

PMID 36139795 Diosmin and Trolox Have Anti-Arthritic, Anti-Inflammatory and Antioxidant Potenc

Antioxidants (Basel)

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables