Relationship Graph Explorer
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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
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Ingredient
44,595
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Gene Target
15,505
→
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Disease
30,170
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
🏥 Disease / Health Topic
Apnea
20
Clinical Trials
16
Meta-Analyses
0
PubMed References
📋 Sample Trials
NCT00182312
Caffeine for Apnea of Prematurity (CAP)
Completed · Phase 3
NCT00273754
The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA).
Completed · Phase 2
NCT01020357
Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study
Completed · Phase 3
📊 Sample Meta-Analyses
CRD42016052844
Effectiveness of caffeine versus aminophylline for apnea of prematurity in preterm neonates of less than or equal to 34 weeks gestation
Apnea of prematurity.
CRD42017069939
Association between obstructive sleep apnea and alcohol, caffeine and tobacco: a systematic review
Sleep apnea (SA) is a common sleep disorder with paused or shallow breathing dur
CRD42018089872
High versus low dose caffeine in preterm infants: a systematic review and meta-analysis
Preterm infants (defined as if born before gestational week 37) is a fragile and
📚 Sample References
None linked yet.
🏥 All Disease / Health Topic data fields for Apnea
🏥 Names
Disease Name
Apnea
Alias Names
Apnoea; Absence of Spontaneous Respiration; Apneic Episodes; Apnea
Topic Type
phenotype
🧬 Ontology Classifications
DisGeNET Type
phenotype
UMLS Type
Sign or Symptom
MeSH Class
Respiratory Tract Diseases; Pathological Conditions, Signs and Symptoms
HPO Class
Abnormality of the respiratory system
🔗 External References
🔍 Raw view — every non-empty column on this row (26 fields)
name
Apnea
alias name
Apnoea; Absence of Spontaneous Respiration; Apneic Episodes; Apnea
topic type
phenotype
disgenet disease type
phenotype
umls disease type
Sign or Symptom
mesh disease class
Respiratory Tract Diseases; Pathological Conditions, Signs and Symptoms
hpo disease class
Abnormality of the respiratory system
umls disease type id
T184
mesh disease class id
C08; C23
hpo disease class id
HP:0002086
herb disease id
HBDIS000222
disgenet id
C0003578
mesh id
D001049
hpo id
HP:0002104
⚗️ Related Ingredients
5 · shared evidence📋 Clinical Trials
12 · subject of clinical studyNCT00182312 Caffeine for Apnea of Prematurity (CAP)
→ Apnea of Prematurity
NCT00273754 The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children
→ Sleep Apnea, Obstructive|Tonsillectomy|Adenoidecto
NCT01020357 Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study
→ Apnea of Prematurity
NCT01435486 Caffeine Citrate for the Treatment of Apnea Associated With Bronchiolitis in You
→ Bronchiolitis|Apnea|Caffeine
NCT02103777 High Versus Low Dose of Caffeine for Apnea of Prematurity
→ Apnea|Preterm Infants
NCT02293824 Effect of Feedings on Caffeine in Premature Infants
→ Apnea of Prematurity|Premature Newborn|Caffeine
NCT02677584 Prophylactic Versus Therapeutic Caffeine for Apnea of Prematurity
→ Apnea
NCT02484300 The Effect of Melatonin on Sleep and Ventilatory Control in Obstructive Sleep Ap
→ Obstructive Sleep Apnea
NCT02566226 Impact of Intrathecal Morphine on Sleep Apnea Syndrome
→ Sleep Apnea Syndromes
NCT02732795 Sleep Apnea and Obesity Affects on Morphine Pharmacokinetics
→ Pediatric Sleep Apnea|Obesity|Morphine Metabolism
NCT02564068 Oxytocin on HR in Sleep Apnea Patient
→ Sleep Apnea
NCT03148899 Impact of Oxytocin on Obstructive Sleep Apnea Induced Changes in Sleep
→ Sleep Apnea, Obstructive
📊 Meta-Analyses
12 · systematic reviewCRD42016052844 Effectiveness of caffeine versus aminophylline for apnea of prematurity in prete
→ Apnea of prematurity.
CRD42017069939 Association between obstructive sleep apnea and alcohol, caffeine and tobacco: a
→ Sleep apnea (SA) is a common sleep disorder with p
CRD42018089872 High versus low dose caffeine in preterm infants: a systematic review and meta-a
→ Preterm infants (defined as if born before gestati
CRD42019122881 Efficacy of caffeine versus aminophylline in the treatment of apnea of prematuri
→ Apnea of prematurity
CRD42020165459 The use of caffeine for the treatment of apnea in neonates (neonatal intensive c
→ Apnea of prematurity (AOP) is a common development
CRD42021277545 Is caffeine therapy for preterm infants able to alter brain activity? A Systemat
→ Disturbances of brain maturation can be related to
CRD42021282536 Caffeine in preterm infants and effects on sleep in the postnatal period, childh
→ Caffeine citrate is the first choice as a therapeu
CRD42022378060 Efficacy and safety of mometasone furoate combined with montelukast for adenoid
→ Adenoid hypertrophy (AH) is a disease caused by ad
CRD42022367322 A systematic review and meta-analysis of norepinephrine reuptake inhibitors comb
→ Obstructive sleep apnea has become a common diseas
CRD42020197436 Effect of testosterone therapy on sleep and sleep disordered breathing：sy
→ Sleep disordered breathing: Respiratory Disorder I
CRD42020215699 Effects of Non-Vitamin K Antagonist Oral Anticoagulats versus Vitamin K Antagoni
→ Atrial fibrillation (AF) is the most prevalent car
CRD42023423265 Caffeine therapy for apnea of prematurity: a systematic review and meta-analysis
→ Preterm infants (defined as if born before gestati
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
empty — needs
HERB_herb_ingredientimport - Ingredient ↔ Target:
empty — needs
HERB_ingredient_targetimport - Target ↔ Disease:
empty — needs
HERB_target_diseaseimport - Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables