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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Epicatechin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Epicatechin

Duchenne Muscular Dystrophy 1 Borderline Hypertension 1 Pharmacological interventions used to manage Friedreich Atax 1 Healthy and/or suffering from cardiometabolic diseases (incl 1 Vasodilation 1 Statin Intolerance 1 Pre-diabetes 1 Hypertension|Endothelial Dysfunction 1 Heart Failure 1

📋 Sample Trials

NCT01691404

Study on the Effects of Epicatechin and Quercetin Supplementation on Vascular Function and Blood Pressure (FLAVO)

Completed

NCT02656212

Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin (Part 2)

Completed · Phase 1

NCT01690676

Effect of an Apple Polyphenol Extract on Brachial Artery Flow-mediated Vasodilatory Function

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42021293038

Effect of (–)-epicatechin intake on cardiometabolic parameters – a systematic review of randomized controlled intervention studies

Healthy and/or suffering from cardiometabolic diseases (incl. pre-stage)

CRD42023481130

Evaluating Pharmacological Interventions for Friedreich Ataxia: A Network Meta-Analysis of Randomised Trials

Pharmacological interventions used to manage Friedreich Ataxia. Friedreich ataxi

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Epicatechin

⚗️ Identity

Name

Epicatechin

Aliases / Synonyms

(-)-Epicatechin; 490-46-0; L-Epicatechin; Epicatechol; l-Acacatechin; (-)-Epicatechol; epi-Catechin; epi-Catechol; (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol

🧪 Chemistry

Molecular Weight

290.2710

LogP

1.5461

Drug-likeness

0.51

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

Isomeric SMILES

C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

InChIKey

PFTAWBLQPZVEMU-UKRRQHHQSA-N

InChI

InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1

🔗 External References

HERB DB

HBIN025287 ↗

PubChem CID

72276 ↗

NPASS

NPC157410

SymMap

1398

TCMID

6853

TCM-ID

4604

🔍 Raw view — every non-empty column on this row (30 fields)

name

Epicatechin

common names

(-)-Epicatechin; 490-46-0; L-Epicatechin; Epicatechol; l-Acacatechin; (-)-Epicatechol; epi-Catechin; epi-Catechol; (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol

herb ingredient id

HBIN025287

canonical smiles

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

isomeric smiles

C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

inchi

InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1

inchikey

PFTAWBLQPZVEMU-UKRRQHHQSA-N

mol wt

290.2710

num h acceptors

num h donors

mol logp

1.5461

num rotatable bonds

drug likeness

0.51

symmap mol id

1398

tcmid ingredient id

6853

tcm id ingredient id

4604

pubchem cid

72276

npass id

NPC157410

🏥 Linked Health Topics

2 · diseases via target pathways

Heart Failure

syndrome

Borderline Hypertension

syndrome

📋 Clinical Trials

7 · subject of clinical study

NCT01691404 Study on the Effects of Epicatechin and Quercetin Supplementation on Vascular Fu

→ Hypertension|Endothelial Dysfunction

NCT02656212 Early Phase Pre-Clinical and Initial Clinical Research on Epicatechin (Part 2)

→ Pre-diabetes

NCT01690676 Effect of an Apple Polyphenol Extract on Brachial Artery Flow-mediated Vasodilat

→ Borderline Hypertension

NCT02292342 An Investigation of the Dose-dependent Vascualr Effects of (-)-Epicatechin in He

→ Vasodilation

NCT02964377 Plus Epicatechin Duchenne Muscular Dystrophy in Non-ambulatory Adolescents

→ Duchenne Muscular Dystrophy

NCT02068040 Effects of Epicatechin on Functional Capacity, Skeletal Muscle Structure and Dia

→ Heart Failure

NCT02490527 Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exe

→ Statin Intolerance

📊 Meta-Analyses

2 · systematic review

CRD42021293038 Effect of (–)-epicatechin intake on cardiometabolic parameters – a systematic re

→ Healthy and/or suffering from cardiometabolic dise

CRD42023481130 Evaluating Pharmacological Interventions for Friedreich Ataxia: A Network Meta-A

→ Pharmacological interventions used to manage Fried

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables