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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

(-)-epigallocatechin-3-gallate

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with (-)-epigallocatechin-3-gallate

Light Chain (AL) Amyloidosis|Cardiac Involvement 1 Cognitive Function|Mood 1 Irreversible Pulpitis 1 Acne Vulgaris 1 Huntington Disease 1 Frailty|Inflammation 1 Fragile X Syndrome 1 Fetal Alcohol Syndrome (FAS) 1 Relapsing-remitting Multiple Sclerosis 1 Esophageal Obstruction 1 Papilloma-induced Cervical Lesions 1 EGCG Influence on Catecholamine Metabolism 1

📋 Sample Trials

NCT00867555

Green Tea, High in Epigallocatechin Gallate (EGCG) and Postprandial Fat Oxidation

Completed

NCT01357681

Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study)

Completed · Phase 2

NCT01687556

EGCG Improves Acne by Modulating Molecular Targets

Completed

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 30822414

A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topical Application of Epigallocatechin-3-Gallate in the Modulation of Cutaneous Scarring in Human Skin

J Invest Dermatol · 2019

PMID 30591655

Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells

Cancers (Basel) · 2018

PMID 29882708

Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila

FASEB J · 2018

⚗️ All Ingredient data fields for (-)-epigallocatechin-3-gallate

⚗️ Identity

Name

(-)-epigallocatechin-3-gallate

Aliases / Synonyms

(-)-Epigallocatechin gallate; EGCG; 989-51-5; Epigallocatechin gallate; Epigallocatechin 3-gallate; Tea catechin; Epigallocatechin-3-gallate; Teavigo; (-)-Epigallocatechin-3-o-gallate; Epigallocatechin-3-monogallate

🧪 Chemistry

Molecular Weight

458.3750

LogP

2.2332

Drug-likeness

0.212

Oral Bioavailability

55.0870

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

Isomeric SMILES

C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

InChIKey

WMBWREPUVVBILR-WIYYLYMNSA-N

InChI

InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1

🔗 External References

HERB DB

HBIN025346 ↗

PubChem CID

65064 ↗

CAS Number

989-51-5 ↗

NPASS

NPC250436

HIT

C0047

TCMID

23283; 30998; 25797; 6922; 39022; 24101

TCMSP

MOL006821

TCM-ID

12177; 9875; 16222; 9917

🔍 Raw view — every non-empty column on this row (33 fields)

name

(-)-epigallocatechin-3-gallate

common names

herb ingredient id

HBIN025346

canonical smiles

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

isomeric smiles

C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

inchi

InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1

inchikey

WMBWREPUVVBILR-WIYYLYMNSA-N

mol wt

458.3750

num h acceptors

num h donors

mol logp

2.2332

num rotatable bonds

drug likeness

0.212

ob score

55.0870

cas id

989-51-5

tcmid ingredient id

23283; 30998; 25797; 6922; 39022; 24101

tcmsp ingredient id

MOL006821

tcm id ingredient id

12177; 9875; 16222; 9917

pubchem cid

65064

npass id

NPC250436

hit id

C0047

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)

Irreversible Pulpitis

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00867555 Green Tea, High in Epigallocatechin Gallate (EGCG) and Postprandial Fat Oxidatio

→ Obesity|Type 2 Diabetes Mellitus

NCT01357681 Effects of EGCG (Epigallocatechin Gallate) in Huntington's Disease (ETON-Study)

→ Huntington Disease

NCT01687556 EGCG Improves Acne by Modulating Molecular Targets

→ Acne Vulgaris

NCT01699711 Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Per

→ Down Syndrome (DS)

NCT02558933 Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcoh

→ Fetal Alcohol Syndrome (FAS)

NCT02891538 Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer

→ Colon Cancer

NCT03199430 Epigallocatechin Gallate Lowers Circulating Catecholamine Concentrations and Alt

→ EGCG Influence on Catecholamine Metabolism

NCT03740295 Impact of Ketone Bodies and Epigallocatechin Gallate in Multiple Sclerosis

→ Multiple Sclerosis

NCT02015312 A Trial for the Treatment of Cardiac AL-Amyloidosis With the Green Tea Compound

→ Light Chain (AL) Amyloidosis|Cardiac Involvement

NCT04553666 Reducing Frailty for Older Cancer Survivors Using Supplements

→ Frailty|Inflammation

NCT00525668 Sunphenon Epigallocatechin-gallate (EGCg) in Relapsing-remitting Multiple Sclero

→ Relapsing-remitting Multiple Sclerosis

NCT00981292 Effects of Epigallocatechin Gallate (EGCG) in Healthy, Young Adults

→ Cognitive Function|Mood

📚 PubMed References

12 · cited research

PMID 30822414 A Double-Blind, Randomized Trial Shows the Role of Zonal Priming and Direct Topi

J Invest Dermatol

PMID 30591655 Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer

Cancers (Basel)

PMID 29882708 Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling an

FASEB J

PMID 29855550 Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal i

Mucosal Immunol

PMID 29031698 Aggregation of Aβ(17-36) in the Presence of Naturally Occurring Phenolic Inhibit

J Mol Biol

PMID 29024813 A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serv

Cancer Lett

PMID 28739640 EGCG ameliorates high-fat- and high-fructose-induced cognitive defects by regula

FASEB J

PMID 28703809 Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection

Cell Death Dis

PMID 26473505 Regulation of Transforming Growth Factor β-Activated Kinase Activation by Epigal

Arthritis Rheumatol

PMID 25721086 Upregulation of B-cell translocation gene 2 by epigallocatechin-3-gallate via p3

Cancer Lett

PMID 24913014 Molecular identification for epigallocatechin-3-gallate-mediated antioxidant int

J Biomed Sci

PMID 24876174 Antifibrotic properties of epigallocatechin-3-gallate in endometriosis

Hum Reprod

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables