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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Ergothioneine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Ergothioneine

Antioxidative Stress|Cold|Influenza|Aging|Inflammation 1

📋 Sample Trials

NCT05190432

Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)

Active_Not_Recruiting

📊 Sample Meta-Analyses

None linked yet.

📚 Sample References

PMID 27101740

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6

Free Radic Biol Med · 2016

PMID 32104530

The Antiaging Activity of Ergothioneine in UVA-Irradiated Human Dermal Fibroblasts via the Inhibition of the AP-1 Pathway and the Activation of Nrf2-Mediated Antioxidant Genes

Oxid Med Cell Longev · 2020

PMID 33964294

Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-κB, and apoptotic signaling and inhibiting γ-glutamyl transpeptidase

Life Sci · 2021

⚗️ All Ingredient data fields for Ergothioneine

⚗️ Identity

Name

Ergothioneine

Aliases / Synonyms

497-30-3; L-(+)-Ergothioneine; L-Ergothioneine; Sympectothion; Ergothionine; Thioneine; l-Thioneine; Thiolhistidine-betaine; L(+)-Ergothioneine

🧪 Chemistry

Molecular Weight

229.3050

LogP

-0.5605

Drug-likeness

0.537

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C[N+](C)(C)C(CC1=CNC(=S)N1)C(=O)[O-]

Isomeric SMILES

C[N+](C)(C)[C@@H](CC1=CNC(=S)N1)C(=O)[O-]

InChIKey

SSISHJJTAXXQAX-ZETCQYMHSA-N

InChI

InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1

🔗 External References

HERB DB

HBIN025561 ↗

PubChem CID

5351619 ↗

NPASS

NPC218262

TCMID

7253

🔍 Raw view — every non-empty column on this row (28 fields)

name

Ergothioneine

common names

497-30-3; L-(+)-Ergothioneine; L-Ergothioneine; Sympectothion; Ergothionine; Thioneine; l-Thioneine; Thiolhistidine-betaine; L(+)-Ergothioneine

herb ingredient id

HBIN025561

canonical smiles

C[N+](C)(C)C(CC1=CNC(=S)N1)C(=O)[O-]

isomeric smiles

C[N+](C)(C)[C@@H](CC1=CNC(=S)N1)C(=O)[O-]

inchi

InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1

inchikey

SSISHJJTAXXQAX-ZETCQYMHSA-N

mol wt

229.3050

num h acceptors

num h donors

mol logp

-0.5605

num rotatable bonds

drug likeness

0.537

tcmid ingredient id

7253

pubchem cid

5351619

npass id

NPC218262

📋 Clinical Trials

1 · subject of clinical study

NCT05190432 Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)

→ Antioxidative Stress|Cold|Influenza|Aging|Inflamma

📚 PubMed References

3 · cited research

PMID 27101740 Ergothioneine oxidation in the protection against high-glucose induced endotheli

Free Radic Biol Med

PMID 32104530 The Antiaging Activity of Ergothioneine in UVA-Irradiated Human Dermal Fibroblas

Oxid Med Cell Longev

PMID 33964294 Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-κ

Life Sci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables