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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Estriol

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Estriol

Vaginal Atrophy 3 Menopause 1 Atrophic Vaginitis 1 Menopause is a transition period marked for many women by fl 1 Vaginal Health 1 Relapsing-remitting Multiple Sclerosis|Secondary-progressive 1 Relapsing Remitting Multiple Sclerosis 1 Pregnancy 1 Multiple Sclerosis|Neurogenic Bladder 1

📋 Sample Trials

NCT00451204

A Combination Trial of Copaxone Plus Estriol in Relapsing Remitting Multiple Sclerosis (RRMS)

Completed · Phase 2

NCT00908570

Topical Estriol for Vaginal Health

Completed · Phase 1

NCT01466114

Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition

Unknown · Phase 2

📊 Sample Meta-Analyses

CRD42021281694

Does the use of estriol bring relief of vasomotor symptoms in the menopausal period? A systematic review and meta-analysis

Menopause is a transition period marked for many women by fluctuating physiologi

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Estriol

⚗️ Identity

Name

Estriol

Aliases / Synonyms

50-27-1; Oestriol; Trihydroxyestrin; Aacifemine; Estratriol; Ovestrion; Destriol; Ovestin; Theelol

🧪 Chemistry

Molecular Weight

288.3870

LogP

2.5800

Drug-likeness

0.687

Oral Bioavailability

27.3160

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O

Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)O)CCC4=C3C=CC(=C4)O

InChIKey

PROQIPRRNZUXQM-ZXXIGWHRSA-N

InChI

InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1

🔗 External References

HERB DB

HBIN025820 ↗

PubChem CID

5756 ↗

CAS Number

50-27-1 ↗

NPASS

NPC214224

TCMID

7385

TCMSP

MOL012142

TCM-ID

4498

🔍 Raw view — every non-empty column on this row (32 fields)

name

Estriol

common names

50-27-1; Oestriol; Trihydroxyestrin; Aacifemine; Estratriol; Ovestrion; Destriol; Ovestin; Theelol

herb ingredient id

HBIN025820

canonical smiles

CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O

isomeric smiles

C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)O)CCC4=C3C=CC(=C4)O

inchi

InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1

inchikey

PROQIPRRNZUXQM-ZXXIGWHRSA-N

mol wt

288.3870

num h acceptors

num h donors

mol logp

2.5800

num rotatable bonds

drug likeness

0.687

ob score

27.3160

cas id

50-27-1

tcmid ingredient id

7385

tcmsp ingredient id

MOL012142

tcm id ingredient id

4498

pubchem cid

5756

npass id

NPC214224

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Atrophic Vaginitis

syndrome

📋 Clinical Trials

10 · subject of clinical study

NCT00451204 A Combination Trial of Copaxone Plus Estriol in Relapsing Remitting Multiple Scl

→ Relapsing Remitting Multiple Sclerosis

NCT00908570 Topical Estriol for Vaginal Health

→ Vaginal Health

NCT01466114 Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition

→ Relapsing-remitting Multiple Sclerosis|Secondary-p

NCT03343912 Estriol and Trimegestone Dose-response Trial With Single Dose Application of Vag

→ Pregnancy

NCT03363997 Pharmacokinetics and Pharmacodynamics of 3 Dosages of Estriol After Continuous V

→ Menopause

NCT04574999 Study to Determine Efficacy & Safety of a Low Concentration Estriol (0.005%) in

→ Vaginal Atrophy

NCT02413008 A Clinical Trial to Assess the Safety of 0.005 % Estriol Vaginal Gel in Hormone

→ Vaginal Atrophy

NCT02967510 Study Evaluating the Efficacy and Safety of Three Formulations of Ultra-low Dose

→ Vaginal Atrophy

NCT03774407 Vaginal Estriol in Multiple Sclerosis

→ Multiple Sclerosis|Neurogenic Bladder

NCT01370551 Clinical Study of Vaginal Lactobacilli and Estriol (Gynoflor®) for Atrophic Vagi

→ Atrophic Vaginitis

📊 Meta-Analyses

1 · systematic review

CRD42021281694 Does the use of estriol bring relief of vasomotor symptoms in the menopausal per

→ Menopause is a transition period marked for many w

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables