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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Eugenol

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Eugenol

Different types cancers 1 Pulpitides|Endodontic Inflammation|Toothaches|Operative Dent 1 There are various adverse effect of both zinc oxide eugenol 1 root canal filling materials used in pulpectomy in primary t 1 Oral cancer has become a global health problem due to its hi 1

📋 Sample Trials

NCT03472456

Endodontic Medications for Irreversible Pulpitis: Articaine or Eugenol?

Completed

📊 Sample Meta-Analyses

CRD42019157503

Antidiabetic effect of eugenol: A meta-analysis of animal studies.

CRD42022297556

Comparative evaluation of adverse effect of zinc oxide eugenol and calcium hydroxide iodoform paste as an obturating material in primary tooth

There are various adverse effect of both zinc oxide eugenol and calcium hydroxid

CRD42022317055

Alternative root canal filling materials to zinc oxide-eugenol in primary teeth

root canal filling materials used in pulpectomy in primary teeth

📚 Sample References

PMID 32089784

Apoptotic Inducement of Neuronal Cells by Aluminium Chloride and the Neuroprotective Effect of Eugenol in Wistar Rats

Oxid Med Cell Longev · 2020

PMID 33245926

Dual role of eugenol on chronic gastric ulcer in rats: Low-dose healing efficacy and the worsening gastric lesion in high doses

Chem Biol Interact · 2021

PMID 33443517

Eugenol emerges as an elixir by targeting β-catenin, the central cancer stem cell regulator in lung carcinogenesis: an in vivo and in vitro rationale

Food Funct · 2021

⚗️ All Ingredient data fields for Eugenol

⚗️ Identity

Name

Eugenol

Aliases / Synonyms

97-53-0; 4-Allyl-2-methoxyphenol; 4-Allylguaiacol; Eugenic acid; Allylguaiacol; p-Eugenol; Caryophyllic acid; 2-Methoxy-4-prop-2-enylphenol; p-Allylguaiacol

🧪 Chemistry

Molecular Weight

164.2040

LogP

2.1293

Drug-likeness

0.693

Oral Bioavailability

56.2420

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

COC1=C(C=CC(=C1)CC=C)O

Isomeric SMILES

COC1=C(C=CC(=C1)CC=C)O

InChIKey

RRAFCDWBNXTKKO-UHFFFAOYSA-N

InChI

InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3,5-7,11H,1,4H2,2H3

🔗 External References

HERB DB

HBIN026067 ↗

PubChem CID

3314 ↗

CAS Number

97-53-0 ↗

NPASS

NPC257124

HIT

C0064

SymMap

TCMID

7520; 38978

TCMSP

MOL000254

TCM-ID

4452; 5858

🔍 Raw view — every non-empty column on this row (34 fields)

name

Eugenol

common names

97-53-0; 4-Allyl-2-methoxyphenol; 4-Allylguaiacol; Eugenic acid; Allylguaiacol; p-Eugenol; Caryophyllic acid; 2-Methoxy-4-prop-2-enylphenol; p-Allylguaiacol

herb ingredient id

HBIN026067

canonical smiles

COC1=C(C=CC(=C1)CC=C)O

isomeric smiles

COC1=C(C=CC(=C1)CC=C)O

inchi

InChI=1S/C10H12O2/c1-3-4-8-5-6-9(11)10(7-8)12-2/h3,5-7,11H,1,4H2,2H3

inchikey

RRAFCDWBNXTKKO-UHFFFAOYSA-N

mol wt

164.2040

num h acceptors

num h donors

mol logp

2.1293

num rotatable bonds

drug likeness

0.693

ob score

56.2420

cas id

97-53-0

symmap mol id

tcmid ingredient id

7520; 38978

tcmsp ingredient id

MOL000254

tcm id ingredient id

4452; 5858

pubchem cid

3314

npass id

NPC257124

hit id

C0064

📋 Clinical Trials

1 · subject of clinical study

NCT03472456 Endodontic Medications for Irreversible Pulpitis: Articaine or Eugenol?

→ Pulpitides|Endodontic Inflammation|Toothaches|Oper

📊 Meta-Analyses

5 · systematic review

CRD42019157503 Antidiabetic effect of eugenol: A meta-analysis of animal studies.

CRD42022297556 Comparative evaluation of adverse effect of zinc oxide eugenol and calcium hydro

→ There are various adverse effect of both zinc oxid

CRD42022317055 Alternative root canal filling materials to zinc oxide-eugenol in primary teeth

→ root canal filling materials used in pulpectomy in

CRD42022364218 Molecular mechanisms of action of Eugenol in cancer: Recent trends and advanceme

→ Different types cancers

CRD42023437406 In Vitro Anticancer Effect of Eugenol on Oral Cancer Cell Lines: A Systematic Re

→ Oral cancer has become a global health problem due

📚 PubMed References

6 · cited research

PMID 32089784 Apoptotic Inducement of Neuronal Cells by Aluminium Chloride and the Neuroprotec

Oxid Med Cell Longev

PMID 33245926 Dual role of eugenol on chronic gastric ulcer in rats: Low-dose healing efficacy

Chem Biol Interact

PMID 33443517 Eugenol emerges as an elixir by targeting β-catenin, the central cancer stem cel

Food Funct

PMID 35436473 Eugenol protects against Aspergillus fumigatus keratitis by inhibiting inflammat

Eur J Pharmacol

PMID 36113730 Nephroprotective potential of eugenol in a rat experimental model of chronic kid

Life Sci

PMID 36526244 Eugenol attenuates ischemia-mediated oxidative stress in cardiomyocytes via acet

Free Radic Biol Med

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables