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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Femara

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Femara

Ectopic Pregnancy 4 Nearly 70% of patients with polycystic ovary syndrome (PCOS) 1 Hypogonadism|Hypogonadism, Male|Hypogonadotropic Hypogonadis 1 Clomiphene and letrozole are the first-line efflux-promoting 1 Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Bre 1 Polycystic ovary syndrome is a common reproductive endocrine 1 Polycystic Ovary Syndrome|Infertility 1 Medical termination of pregnancy. 1 Gestational Trophoblastic Disease 1 Clinical effect and safety of endometrial preparation protoc 1 Anatomic Stage I Breast Cancer AJCC v8|Anatomic Stage II Bre 1 Polycystic ovary syndrome is a common gynecological endocrin 1

📋 Sample Trials

NCT05454358

Letrozole as Maintenance Therapy for Post-surgical Endometrial Cancer Patients With NSMP

Recruiting · Phase 2|Phase 3

NCT05487092

Letrozole in Preventing Recurrence of Endometrioma Following Laparoscopic Ovarian Cystectomy

Recruiting

NCT05203562

Letrozole as a Prophylaxis From GTN for Complete Mole Patients

Unknown · Phase 2|Phase 3

📊 Sample Meta-Analyses

CRD42020164027

Effect of Letrozole on Endometrial Preparation in Frozen-thawed Embryo Transfer Cycles: a Systematic Review and Meta-analysis

Clinical effect and safety of endometrial preparation protocols in frozen-thawed

CRD42021250345

Efficacy and safety of letrozole in the management of constitutional delay in growth and puberty: A systematic review and meta-analysis

Constitutional delay in growth and puberty (CDGP) is perhaps the most common cau

CRD42016039663

Comparison of clomiphene citrate and letrozole for infertility treatment in polycystic ovary syndrome: a systematic review and meta-analysis

Polycystic ovary syndrome is a common condition that affects 7-12% of the female

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Femara

⚗️ Identity

Name

Femara

Aliases / Synonyms

letrozole; 112809-51-5; 4,4'-((1h-1,2,4-triazol-1-yl)methylene)dibenzonitrile; Letrozol; CGS 20267; Letoval; CGS-20267; Benzonitrile, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-; 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile

🧪 Chemistry

Molecular Weight

285.3100

LogP

2.6592

Drug-likeness

0.741

Oral Bioavailability

66.0910

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

Isomeric SMILES

C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

InChIKey

HPJKCIUCZWXJDR-UHFFFAOYSA-N

InChI

InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H

🔗 External References

HERB DB

HBIN026423 ↗

PubChem CID

3902 ↗

CAS Number

112809-51-5 ↗

NPASS

NPC52764

SymMap

11126

TCMSP

MOL010055

🔍 Raw view — every non-empty column on this row (31 fields)

name

Femara

common names

herb ingredient id

HBIN026423

canonical smiles

C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

isomeric smiles

C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

inchi

InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H

inchikey

HPJKCIUCZWXJDR-UHFFFAOYSA-N

mol wt

285.3100

num h acceptors

num h donors

mol logp

2.6592

num rotatable bonds

drug likeness

0.741

ob score

66.0910

cas id

112809-51-5

symmap mol id

11126

tcmsp ingredient id

MOL010055

pubchem cid

3902

npass id

NPC52764

🏥 Linked Health Topics

4 · studied for these conditions (text bridge)

Polycystic Ovary Syndrome

syndrome

Ectopic Pregnancy

phenotype

Gestational Trophoblastic Disease

syndrome

Miscarriage

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT05454358 Letrozole as Maintenance Therapy for Post-surgical Endometrial Cancer Patients W

→ Endometrial Cancer

NCT05487092 Letrozole in Preventing Recurrence of Endometrioma Following Laparoscopic Ovaria

→ Endometriotic Cyst of Ovary

NCT05203562 Letrozole as a Prophylaxis From GTN for Complete Mole Patients

→ Gestational Trophoblastic Disease

NCT05198050 Letrozole in Induction of Abortion of Anembryonic Pregnancy

→ Anembryonic Pregnancy

NCT05207644 Letrozole and Misoprostol for Termination of Pregnancy up to 63 Days' Gestation

→ Pregnancy

NCT05198141 Evaluation of Different Doses of Letrozole in Ectopic Pregnancy

→ Ectopic Pregnancy

NCT05464810 Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone

→ Anatomic Stage I Breast Cancer AJCC v8|Anatomic St

NCT05206448 Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Let

→ Polycystic Ovary Syndrome|PCOS|Infertility

NCT05601700 Letrozole for Estrogen/Progesterone Receptor Positive Low-grade Serous Epithelia

→ Carcinoma, Ovarian Epithelial|Low Grade Serous Ade

NCT05304273 Comparison Between Letrozole and Mifepristone in Medical Termination of First Tr

→ Miscarriage

NCT05227391 Live Birth After Letrozole-stimulated Cycles Versus Hormone Replacement Treatmen

→ PCOS

NCT05205837 A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects

→ Hypogonadism|Hypogonadism, Male|Hypogonadotropic H

📊 Meta-Analyses

12 · systematic review

CRD42020164027 Effect of Letrozole on Endometrial Preparation in Frozen-thawed Embryo Transfer

→ Clinical effect and safety of endometrial preparat

CRD42021250345 Efficacy and safety of letrozole in the management of constitutional delay in gr

→ Constitutional delay in growth and puberty (CDGP)

CRD42016039663 Comparison of clomiphene citrate and letrozole for infertility treatment in poly

→ Polycystic ovary syndrome is a common condition th

CRD42016047544 Letrozole prior to medical termination of pregnancy: a systematic review and met

→ Medical termination of pregnancy.

CRD42017053966 Ovarian stimulation in intra uterine insemination with clomiphene citrate, letro

→ Couples with unexplained or mild male subfertility

CRD42017082260 Risk of harm associated with the use of letrozole as a fertility drug: a systema

→ Risk of congenital malformations with the use of L

CRD42018094001 Letrozole versus clomiphene citrate for unexplained infertility: a systematic re

→ Efficacy of clomid versus letrozole for ovulation

CRD42018105820 Intrauterine insemination for unexplained subfertility in a natural cycle, with

→ We studied couples with unexplained subfertility

CRD42019121272 Congenital malformations following fertility treatment with clomiphene citrate,

→ The prevalence and relative risk of congenital mal

CRD42019125166 Effect of letrozole on ovulation induction outcome in subfertile women with poly

→ Infertile women with PCOS receiving ovulation indu

CRD42019129850 Comparative effectiveness of tamoxifene, toremifene, letrozole, anastrozole and

→ Breast cancer (BC) is one of the most common malig

CRD42019144657 Effects of clomiphene and letrozole on progesterone levels after ovulatory induc

→ Clomiphene and letrozole are the first-line efflux

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables