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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Fisetin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Fisetin

Frail Elderly Syndrome 2 Carpal Tunnel Syndrome 1 Aging|Endothelial Dysfunction|Arterial Stiffness 1 Covid19|SARS-CoV Infection 1 Covid19|Coronavirus Infection 1 Covid19 1

📋 Sample Trials

NCT04476953

COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation

Enrolling_By_Invitation · Phase 2

NCT04771611

COVFIS-HOME: COVID-19 Pilot Study of Fisetin to Alleviate Dysfunction and Decrease Complications

Completed · Phase 2

NCT03430037

Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Women

Enrolling_By_Invitation · Phase 2

📊 Sample Meta-Analyses

CRD42021298815

The effects of fisetin on musculoskeletal system: A systematic review.

📚 Sample References

PMID 31540162

Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models

Cells · 2019

PMID 31438640

Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9

Cells · 2019

PMID 31207963

Phytomedicine-Based Potent Antioxidant, Fisetin Protects CNS-Insult LPS-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment

J Clin Med · 2019

⚗️ All Ingredient data fields for Fisetin

⚗️ Identity

Name

Fisetin

Aliases / Synonyms

528-48-3; 5-Desoxyquercetin; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one; 3,3',4',7-Tetrahydroxyflavone; Fustel; Viset; 3,7,3',4'-Tetrahydroxyflavone; Fisetholz; Superfustel

🧪 Chemistry

Molecular Weight

286.2390

LogP

2.2824

Drug-likeness

0.511

Oral Bioavailability

52.5960

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

Isomeric SMILES

C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

InChIKey

XHEFDIBZLJXQHF-UHFFFAOYSA-N

InChI

InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H

🔗 External References

HERB DB

HBIN026506 ↗

PubChem CID

5281614 ↗

CAS Number

528-48-3 ↗

NPASS

NPC51443

HIT

C0074

SymMap

327

TCMID

7801

TCMSP

MOL013179

TCM-ID

4358

🔍 Raw view — every non-empty column on this row (34 fields)

name

Fisetin

common names

528-48-3; 5-Desoxyquercetin; 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one; 3,3',4',7-Tetrahydroxyflavone; Fustel; Viset; 3,7,3',4'-Tetrahydroxyflavone; Fisetholz; Superfustel

herb ingredient id

HBIN026506

canonical smiles

C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

isomeric smiles

C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O

inchi

InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H

inchikey

XHEFDIBZLJXQHF-UHFFFAOYSA-N

mol wt

286.2390

num h acceptors

num h donors

mol logp

2.2824

num rotatable bonds

drug likeness

0.511

ob score

52.5960

cas id

528-48-3

symmap mol id

327

tcmid ingredient id

7801

tcmsp ingredient id

MOL013179

tcm id ingredient id

4358

pubchem cid

5281614

npass id

NPC51443

hit id

C0074

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Carpal Tunnel Syndrome

syndrome

📋 Clinical Trials

7 · subject of clinical study

NCT04476953 COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Infla

→ Covid19

NCT04771611 COVFIS-HOME: COVID-19 Pilot Study of Fisetin to Alleviate Dysfunction and Decrea

→ Covid19|Coronavirus Infection

NCT03430037 Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older W

→ Frail Elderly Syndrome

NCT03675724 Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older A

→ Frail Elderly Syndrome

NCT04537299 COVID-FIS: Pilot in COVID-19 (SARS-CoV-2) of Fisetin in Older Adults in Nursing

→ Covid19|SARS-CoV Infection

NCT05416515 A Study of Fisetin to Treat Carpal Tunnel Syndrome

→ Carpal Tunnel Syndrome

NCT06133634 Fisetin to Improve Vascular Function in Older Adults

→ Aging|Endothelial Dysfunction|Arterial Stiffness

📊 Meta-Analyses

1 · systematic review

CRD42021298815 The effects of fisetin on musculoskeletal system: A systematic review.

📚 PubMed References

12 · cited research

PMID 31540162 Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pat

Cells

PMID 31438640 Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma thro

Cells

PMID 31207963 Phytomedicine-Based Potent Antioxidant, Fisetin Protects CNS-Insult LPS-Induced

J Clin Med

PMID 30760707 Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum s

Cell Death Dis

PMID 31634424 Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG

Biofactors

PMID 31835147 Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induce

J Nutr Biochem

PMID 31906440 GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zeb

Int J Mol Sci

PMID 32184730 Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy

Front Pharmacol

PMID 32661350 Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibit

Acta Pharmacol Sin

PMID 33093461 Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA dama

Cell Death Dis

PMID 33178686 Fisetin Promotes Hair Growth by Augmenting TERT Expression

Front Cell Dev Biol

PMID 33381023 Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveo

Front Pharmacol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables