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trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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⚗️ Ingredient

Folinic acid

Open on HERB 2.0 ↗
28
Clinical Trials
0
Meta-Analyses
0
PubMed References
Top Conditions Studied with Folinic acid
Colorectal Cancer 4 Metastatic Colorectal Cancer 2 Autism Spectrum Disorder 2 Gastric Cancer 2 Down Syndrome 2 Human Immunodeficiency Virus (HIV) Infection 1 Advanced Colorectal Cancer|Adenocarcinoma of the Colon|Adeno 1 HIV Infection|HCV Coinfection 1 Unresectable Metastatic Colorectal Cancer 1 Gastrointestinal Neoplasms|Neoplasm Metastasis 1 Solid Tumors 1 Rectal Cancer 1
📋 Sample Trials
NCT00192075
A Randomized Trial of Avastin + Gemcitabine + 5-Fluorouracil (5FU)/Folinic Acid Versus Avastin + Oxaliplatin + 5FU/Folinic Acid in Metastatic Colorectal Cancer
Completed · Phase 2
NCT00294593
Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome
Completed · Phase 2|Phase 3
NCT00759226
Chemotherapeutic Trial With Gemcitabine, Cisplatin, 5-FU and Folinic Acid in Esophageal Cancer
Completed · Phase 2
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
None linked yet.
⚗️ All Ingredient data fields for Folinic acid
⚗️ Identity
Name
Folinic acid
Aliases / Synonyms
leucovorin; 5-Formyltetrahydrofolic acid; 58-05-9; folinate; Welcovorin; Leucal; Acide folinique; Folinic acid-SF; Wellcovorin
🧪 Chemistry
Molecular Weight
473.4460
LogP
-0.7311
Drug-likeness
0.213
Oral Bioavailability
23.6000
H-Bond Acceptors
9
H-Bond Donors
7
Rotatable Bonds
10
🔬 Structures
Canonical SMILES
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Isomeric SMILES
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChIKey
VVIAGPKUTFNRDU-ABLWVSNPSA-N
InChI
InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
🔗 External References
HERB DB
HBIN026629 ↗
PubChem CID
135403648 ↗
CAS Number
21314 ↗
TCMID
30968; 7852
TCMSP
MOL003845
TCM-ID
24646
🔍 Raw view — every non-empty column on this row (31 fields)
name
Folinic acid
common names
leucovorin; 5-Formyltetrahydrofolic acid; 58-05-9; folinate; Welcovorin; Leucal; Acide folinique; Folinic acid-SF; Wellcovorin
herb ingredient id
HBIN026629
canonical smiles
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
isomeric smiles
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
inchi
InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
inchikey
VVIAGPKUTFNRDU-ABLWVSNPSA-N
mol wt
473.4460
num h acceptors
9
num h donors
7
mol logp
-0.7311
num rotatable bonds
10
drug likeness
0.213
ob score
23.6000
cas id
21314
tcmid ingredient id
30968; 7852
tcmsp ingredient id
MOL003845
tcm id ingredient id
24646
pubchem cid
135403648

🏥 Linked Health Topics

3 · studied for these conditions (text bridge)
Colorectal Neoplasms
group
Down Syndrome
syndrome
Diabetic Foot Ulcer
syndrome

📋 Clinical Trials

12 · subject of clinical study
NCT00192075 A Randomized Trial of Avastin + Gemcitabine + 5-Fluorouracil (5FU)/Folinic Acid
→ Colorectal Cancer
NCT00294593 Efficacy Study of Folinic Acid to Improve Mental Development of Children With Do
→ Down Syndrome
NCT00759226 Chemotherapeutic Trial With Gemcitabine, Cisplatin, 5-FU and Folinic Acid in Eso
→ Esophageal Cancer
NCT01060501 Modulation of Adjuvant 5-FU by Folinic Acid and Interferon-alpha in Colon Cancer
→ Rectal Cancer
NCT01228734 A Trial to Compare Oxaliplatin, Folinic Acid (FA) and 5-Fluorouracil (5FU) Combi
→ Metastatic Colorectal Cancer
NCT01576705 Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormon
→ Down Syndrome
NCT01768182 Folinic Acid and Vascular Reactivity in HIV
→ Human Immunodeficiency Virus (HIV) Infection
NCT02810275 Folinic Acid: Supplementation and Therapy
→ HIV Infection|HCV Coinfection
NCT02928224 Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuxi
→ BRAF V600E-mutant Metastatic Colorectal Cancer
NCT03771560 Folinic Acid in Autism
→ Autism Spectrum Disorder
NCT05013164 Role of Folinic Acid in Improving the Adaptive Skills and Language Impairment in
→ Autism Spectrum Disorder
NCT00145314 FLOX in Combination With Cetuximab in First-line Treatment of Colorectal Cancer
→ Metastatic Colorectal Cancer
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables