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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Genistein

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Genistein

Metabolic Syndrome 2 Menopause|Osteopenia 2 Cancer 2 Breast Cancer 2 Metabolic Syndrome|Obesity 1 Bladder Cancer 1 in this review the effect of genistein supplementation on bo 1 Alzheimer's Disease 1 Hot flash (hot flush) in postmenopausal women. 1 Central features of metabolic syndrome (MetS). 1 Kidney Cancer|Melanoma (Skin) 1 Bone density loss in postmenopausal women. 1

📋 Sample Trials

NCT00001696

A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor

Completed · Phase 1

NCT00016744

Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis)

Completed · Phase 1|Phase 2

NCT00099008

Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women

Completed · Phase 1

📊 Sample Meta-Analyses

CRD42017069513

Systematic review and meta-analysis of effect of genistein on endometrial thickness in postmenopausal women

Postmenopausal estrogen decline increases incidence of vasomotor symptoms, cardi

CRD42017069604

Effect of genistein on bone mineral density in postmenopausal women: a systematic review and meta-analysis

Bone density loss in postmenopausal women.

CRD42017069617

Effect of genistein on hot flash in postmenopausal women :a systematic review and meta-analysis

Hot flash (hot flush) in postmenopausal women.

📚 Sample References

PMID 31747621

Fetal and neonatal genistein exposure aggravates to interfere with ovarian follicle development of obese female mice induced by high-fat diet

Food Chem Toxicol · 2020

PMID 31795012

Genistein protects against amyloid-beta-induced toxicity in SH-SY5Y cells by regulation of Akt and Tau phosphorylation

Phytother Res · 2020

PMID 32078221

Anti-invasive effect and pharmacological mechanism of genistein against colorectal cancer

Biofactors · 2020

⚗️ All Ingredient data fields for Genistein

⚗️ Identity

Name

Genistein

Aliases / Synonyms

446-72-0; Prunetol; 4',5,7-Trihydroxyisoflavone; Genisterin; Genisteol; Sophoricol; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7,4'-Trihydroxyisoflavone; Bonistein

🧪 Chemistry

Molecular Weight

270.2400

LogP

2.5768

Drug-likeness

0.632

Oral Bioavailability

17.9330

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O

Isomeric SMILES

C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O

InChIKey

TZBJGXHYKVUXJN-UHFFFAOYSA-N

InChI

InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

🔗 External References

HERB DB

HBIN027456 ↗

PubChem CID

5280961 ↗

CAS Number

446-72-0 ↗

NPASS

NPC39426

HIT

C0101

SymMap

TCMID

8277

TCMSP

MOL000481

TCM-ID

4137

🔍 Raw view — every non-empty column on this row (34 fields)

name

Genistein

common names

446-72-0; Prunetol; 4',5,7-Trihydroxyisoflavone; Genisterin; Genisteol; Sophoricol; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7,4'-Trihydroxyisoflavone; Bonistein

herb ingredient id

HBIN027456

canonical smiles

C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O

isomeric smiles

C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O

inchi

InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

inchikey

TZBJGXHYKVUXJN-UHFFFAOYSA-N

mol wt

270.2400

num h acceptors

num h donors

mol logp

2.5768

num rotatable bonds

drug likeness

0.632

ob score

17.9330

cas id

446-72-0

symmap mol id

tcmid ingredient id

8277

tcmsp ingredient id

MOL000481

tcm id ingredient id

4137

pubchem cid

5280961

npass id

NPC39426

hit id

C0101

🏥 Linked Health Topics

4 · studied for these conditions (text bridge)

Endometrial Hyperplasia

syndrome

Coronary Artery Disease

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00001696 A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor

→ Cancer

NCT00016744 Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis

→ Cystic Fibrosis

NCT00099008 Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal W

→ Breast Cancer|Endometrial Cancer

NCT00118040 Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer

→ Recurrent Bladder Carcinoma|Stage I Bladder Cancer

NCT00244933 Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast C

→ Breast Cancer

NCT00276835 Genistein and Interleukin-2 in Treating Patients With Metastatic Melanoma or Kid

→ Kidney Cancer|Melanoma (Skin)

NCT00290758 Genistein in Preventing Breast Cancer in Women at High Risk for Breast Cancer

→ Breast Cancer

NCT00355953 Vascular and Skeletal Protective Effects of Genistein in Postmenopausal Women

→ Menopause|Osteopenia

NCT00376948 Genistein, Gemcitabine, and Erlotinib in Treating Patients With Locally Advanced

→ Pancreatic Cancer

NCT00541710 Effect of Genistein in Women With Metabolic Syndrome

→ Metabolic Syndrome

NCT01325311 Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Sta

→ Prostate Adenocarcinoma|Stage I Prostate Cancer|St

NCT01489813 Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer Treatm

→ Bladder Cancer

📊 Meta-Analyses

11 · systematic review

CRD42017069513 Systematic review and meta-analysis of effect of genistein on endometrial thickn

→ Postmenopausal estrogen decline increases incidenc

CRD42017069604 Effect of genistein on bone mineral density in postmenopausal women: a systemati

→ Bone density loss in postmenopausal women.

CRD42017069617 Effect of genistein on hot flash in postmenopausal women :a systematic review an

→ Hot flash (hot flush) in postmenopausal women.

CRD42022310933 Safety and Efficacy of Genistein in Sanfilippo Syndrome - A Systematic Review

→ Sanfilippo Syndrome (MPS III)

CRD42022322440 Therapeutic effects and mechanisms of action of genistein on in Non-alcoholic fa

→ Non-alcoholic fatty liver disease (NAFLD), one of

CRD42022325833 The effect of genistein supplementation on glycemic control and insulin sensitiv

→ In this study, we will review the effect of genist

CRD42022327627 the effect of genistein supplementation on body weight and body composition:a sy

→ in this review the effect of genistein supplementa

CRD42023429624 Genistein and daidzein with the risk of prostate cancer：a meta-analysis

→ According to the International Agency for Research

CRD42023407110 Soy isoflavones as treatment of metabolic syndrome central features: A systemati

→ Central features of metabolic syndrome (MetS).

CRD42023394681 Effects of genistein on intestinal health in murine models: a systematic review

CRD42023480278 Effects of Isoflavonoids and Vitamin D Synergism on Bone Mineral Density – A Sys

→ osteopenia, osteoporosis (bone mineral density)

📚 PubMed References

12 · cited research

PMID 31747621 Fetal and neonatal genistein exposure aggravates to interfere with ovarian folli

Food Chem Toxicol

PMID 31795012 Genistein protects against amyloid-beta-induced toxicity in SH-SY5Y cells by reg

Phytother Res

PMID 32078221 Anti-invasive effect and pharmacological mechanism of genistein against colorect

Biofactors

PMID 32115816 Protective effects of Genistein on the cognitive deficits induced by chronic sle

Phytother Res

PMID 32129363 Genistein inhibits high fat diet-induced obesity through miR-222 by targeting BT

Food Funct

PMID 32278794 Role of the TLR4-androgen receptor axis and genistein in taxol-resistant ovarian

Biochem Pharmacol

PMID 32361609 miR-222 is involved in the regulation of genistein on skeletal muscle fiber type

J Nutr Biochem

PMID 32440504 Genistein inhibits angiogenesis developed during rheumatoid arthritis through th

J Orthop Translat

PMID 32610494 Soy Isoflavone Genistein Impedes Cancer Stemness and Mesenchymal Transition in H

Nutrients

PMID 32824087 Soy Isoflavone Genistein Inhibits an Axillary Osmidrosis Risk Factor ABCC11: In

Nutrients

PMID 32824312 Genistein Induces Adipogenic and Autophagic Effects in Rainbow Trout ( Oncorhync

Int J Mol Sci

PMID 33129924 Genistein inhibits radiation-induced invasion and migration of glioblastoma cell

Radiother Oncol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables