AlternativeMed
Ancient Wisdom Natural Remedies Modern Wellness
Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿
Herb
6,826
→
⚗️
Ingredient
44,598
→
🧬
Gene Target
15,695
→
🏥
Disease
30,467
→
🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases
Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins
⚗️ Ingredient

Genkwanin

Open on HERB 2.0 ↗
0
Clinical Trials
0
Meta-Analyses
1
PubMed References
📋 Sample Trials
None linked yet.
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 35870686
Uncovering the efficacy and mechanisms of Genkwa flos and bioactive ingredient genkwanin against L. monocytogenes infection
J Ethnopharmacol · 2022
⚗️ All Ingredient data fields for Genkwanin
⚗️ Identity
Name
Genkwanin
Aliases / Synonyms
437-64-9; 4',5-Dihydroxy-7-methoxyflavone; Gengkwanin; Puddumetin; 7-O-Methylapigenin; 5,4'-Dihydroxy-7-methoxyflavone; 7-Methoxyapigenin; Apigenin 7-methyl ether; Gonkwanin
🧪 Chemistry
Molecular Weight
284.2670
LogP
2.8798
Drug-likeness
0.756
H-Bond Acceptors
5
H-Bond Donors
2
Rotatable Bonds
2
🔬 Structures
Canonical SMILES
COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O
Isomeric SMILES
COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O
InChIKey
JPMYFOBNRRGFNO-UHFFFAOYSA-N
InChI
InChI=1S/C16H12O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
🔗 External References
HERB DB
HBIN027475 ↗
PubChem CID
5281617 ↗
NPASS
NPC234133
TCMID
8288; 40931
TCMSP
MOL005573
TCM-ID
4132
🔍 Raw view — every non-empty column on this row (32 fields)
name
Genkwanin
common names
437-64-9; 4',5-Dihydroxy-7-methoxyflavone; Gengkwanin; Puddumetin; 7-O-Methylapigenin; 5,4'-Dihydroxy-7-methoxyflavone; 7-Methoxyapigenin; Apigenin 7-methyl ether; Gonkwanin
herb ingredient id
HBIN027475
canonical smiles
COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O
isomeric smiles
COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O
inchi
InChI=1S/C16H12O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
inchikey
JPMYFOBNRRGFNO-UHFFFAOYSA-N
mol wt
284.2670
num h acceptors
5
num h donors
2
mol logp
2.8798
num rotatable bonds
2
drug likeness
0.756
tcmid ingredient id
8288; 40931
tcmsp ingredient id
MOL005573
tcm id ingredient id
4132
pubchem cid
5281617
npass id
NPC234133
tcmsp mol id
MOL005573
tcmsp molecule id
5573

🌿 Related Herbs

1 · contains this compound
Ephedra
Ma Huang

🧬 Gene / Protein Targets

14 · directly binds these targets
AR
Gene AR
NCOA1
Gene NCOA1
NCOA2
Gene NCOA2
Prostaglandin G/H synthase 1
Prostaglandin G/H synthase 2
Heat shock protein HSP 90
Dipeptidyl peptidase IV
Trypsin-1
Nitric oxide synthase, inducible
mRNA of PKA Catalytic Subunit C-alpha
Calmodulin
Retinoic acid receptor RXR-alpha
Estrogen receptor beta
Serine/threonine-protein kinase Chk1

🏥 Linked Health Topics

30 · diseases via target pathways
Hypospadias 1, X-Linked
syndrome
Prostate cancer
disease
Spinal and bulbar muscular atrophy
disease
XY disorders of sex development (Other)
disease
XY disorders of sex development (Disorders in androgen synthesis or action)
disease
Spinal and bulbar muscular atrophy of Kennedy
disease
Androgen insensitivity
disease
Cardiovascular disease, unspecified
disease
Chronic inflammatory diseases
disease
Alzheimer'S Disease
syndrome
Arthritis
syndrome
Renal Cell Carcinoma
disease
Carpal Tunnel Syndrome
syndrome
Endometriosis
syndrome
Inflammation
phenotype
Meningioma
disease
Myocardial Infarction
syndrome
Peutz-Jeghers Syndrome
syndrome
Malignant Mesothelioma
disease
Colorectal cancer
disease
Cancer, unspecific
disease
Lung Cancer
disease
Osteoarthritis
disease
Breast cancer
disease
Rheumatoid arthritis, unspecified
disease
Analgesics
disease
Stroke
disease
Inflammatory diseases
disease
Bladder cancer
disease
Abdominal aortic aneurysm
disease

📚 PubMed References

1 · cited research
PMID 35870686 Uncovering the efficacy and mechanisms of Genkwa flos and bioactive ingredient g
J Ethnopharmacol
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables