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trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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⚗️ Ingredient

Glucosamine

Open on HERB 2.0 ↗
17
Clinical Trials
13
Meta-Analyses
1
PubMed References
Top Conditions Studied with Glucosamine
Osteoarthritis 3 Osteoarthritis of the Knee 2 Knee Osteoarthritis 2 Osteoarthritis|Glucosamine|Diacerein 1 Healthy Subject 1 Risk of cancer. 1 Osteoarthritis, Knee 1 Breast Cancer|Joint Pain 1 Patients with knee osteoarthritis. Pain relief and function 1 Patients with knee osteoarthritis 1 Osteoarthritis of Knee 1 Osteoarthritis (OA), a chronic disease characterized by the 1
📋 Sample Trials
NCT00032890
Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
Completed · Phase 3
NCT00086229
Absorption and Distribution of Glucosamine and Chondroitin
Completed
NCT00377286
Effect of Glucosamine on Joint Structure and Quality of Life (JOG)
Completed
📊 Sample Meta-Analyses
CRD42011001295
Study sponsor, active compound, dosing, and label as explanation of inconsistency in glucosamine for osteoarthritis trials: a systematic review and meta-analysis of randomised placebo-controlled trials
Osteoarthritis (OA) is a chronic disease which can manifest itself in all synovi
CRD42016036998
Effects of glucosamine in patients with osteoarthritis of the knee: protocol for a systematic review and meta-analysis
Patients with knee osteoarthritis
CRD42017063775
Effects of glucosamine and chondroitin supplements on symptomatic temporomandibular joint disorders: a systematic review
Temporomandibular joint disorders are characterized as a group of conditions ass
📚 Sample References
PMID 31204557
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling
Autophagy · 2020
⚗️ All Ingredient data fields for Glucosamine
⚗️ Identity
Name
Glucosamine
Aliases / Synonyms
2-Amino-2-Deoxy-D-Glucopyranose; 2-Amino-2-Deoxy-D-Glucopyranoside; 2-Amino-2-Deoxy-D-Glucose; 2-Amino-2-Deoxy-Glucopyranose; 2-Amino-2-Deoxy-Glucopyranoside; 2-Amino-2-Deoxy-Glucose; 2-Deoxy-2-Amino-D-Glucopyranose; 2-Deoxy-2-Amino-D-Glucopyranoside; 2-Deoxy-2-Amino-D-Glucose; 2-Deoxy-2-Amino-Glucopyranose
🧪 Chemistry
Molecular Weight
179.1720
LogP
-3.2550
Drug-likeness
0.288
H-Bond Acceptors
6
H-Bond Donors
5
Rotatable Bonds
1
🔬 Structures
Canonical SMILES
C(C1C(C(C(C(O1)O)N)O)O)O
Isomeric SMILES
C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)N)O)O)O
InChIKey
MSWZFWKMSRAUBD-IVMDWMLBSA-N
InChI
InChI=1S/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6?/m1/s1
🔗 External References
HERB DB
HBIN028036 ↗
PubChem CID
439213 ↗
NPASS
NPC322801
TCMID
8752
🔍 Raw view — every non-empty column on this row (28 fields)
name
Glucosamine
common names
2-Amino-2-Deoxy-D-Glucopyranose; 2-Amino-2-Deoxy-D-Glucopyranoside; 2-Amino-2-Deoxy-D-Glucose; 2-Amino-2-Deoxy-Glucopyranose; 2-Amino-2-Deoxy-Glucopyranoside; 2-Amino-2-Deoxy-Glucose; 2-Deoxy-2-Amino-D-Glucopyranose; 2-Deoxy-2-Amino-D-Glucopyranoside; 2-Deoxy-2-Amino-D-Glucose; 2-Deoxy-2-Amino-Glucopyranose
herb ingredient id
HBIN028036
canonical smiles
C(C1C(C(C(C(O1)O)N)O)O)O
isomeric smiles
C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)N)O)O)O
inchi
InChI=1S/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/t2-,3-,4-,5-,6?/m1/s1
inchikey
MSWZFWKMSRAUBD-IVMDWMLBSA-N
mol wt
179.1720
num h acceptors
6
num h donors
5
mol logp
-3.2550
num rotatable bonds
1
drug likeness
0.288
tcmid ingredient id
8752
pubchem cid
439213
npass id
NPC322801

🏥 Linked Health Topics

3 · studied for these conditions (text bridge)
Inflammation
phenotype
Low Back Pain
phenotype
Osteoarthritis, Knee
syndrome

📋 Clinical Trials

12 · subject of clinical study
NCT00032890 Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
→ Osteoarthritis
NCT00086229 Absorption and Distribution of Glucosamine and Chondroitin
→ Osteoarthritis
NCT00377286 Effect of Glucosamine on Joint Structure and Quality of Life (JOG)
→ Osteoarthritis
NCT00691678 Glucosamine and Chondroitin for Aromatase Inhibitor Induced Joint Symptoms in Wo
→ Breast Cancer|Joint Pain
NCT01682694 Glucosamine and Chondroitin Effects
→ Inflammation
NCT03717714 Polycan in Combination With Glucosamine for Treatment of Knee Osteoarthritis
→ Osteoarthritis of the Knee
NCT03827161 Glucosamine and Chondroitin in Preventing Inflammation in Overweight Patients
→ Healthy Subject|Overweight
NCT04665804 Effects of Creatine Supplementation as Compared to Glucosamine/Chondroitin Sulfa
→ Knee Osteoarthritis
NCT00805519 Efficacy and Safety of Prednisolone and Chloroquine Add on Therapy in Osteoarthr
→ Osteoarthritis of the Knee
NCT02178137 Effect of Interventions on the Progression of Knee Osteoarthritis
→ Osteo Arthritis of the Knees
NCT02830919 Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee
→ Osteoarthritis of Knee
NCT00110474 Glucosamine Unum In Die [Once A Day] Efficacy (GUIDE) Trial: Glucosamine Sulfate
→ Knee Osteoarthritis

📊 Meta-Analyses

12 · systematic review
CRD42011001295 Study sponsor, active compound, dosing, and label as explanation of inconsistenc
→ Osteoarthritis (OA) is a chronic disease which can
CRD42016036998 Effects of glucosamine in patients with osteoarthritis of the knee: protocol for
→ Patients with knee osteoarthritis
CRD42017063775 Effects of glucosamine and chondroitin supplements on symptomatic temporomandibu
→ Temporomandibular joint disorders are characterize
CRD42018100510 The cancer risks of glucosamine containing nutritional supplements: a systematic
→ Risk of cancer.
CRD42020179570 Glucosamine sulphate: an umbrella review of health outcomes
→ GS is traditionally used for knee osteoarthritis.
CRD42020202093 Identify the effects of the combination of glucosamine and chondroitin in patien
→ Patients with knee osteoarthritis. Pain relief and
CRD42022321739 The use of Glucosamine and colorectal cancer risk: a systematic review and meta-
→ Human colorectal cancer is a common malignant tumo
CRD42022322480 The Efficacy and Safety of Xianling Gubao Capsule Combined With Glucosamine in t
→ Knee osteoarthritis (KOA) is a chronic arthritic d
CRD42022331863 Relative effectiveness of glucosamine combined with pharmacological intervention
→ Knee osteoarthritis (KOA) is a common chronic diso
CRD42022340815 Efcacy and safety of the combination of glucosamine and Nonsteroidal-anti-inflam
→ Osteoarthritis (OA), a chronic disease characteriz
CRD42022367761 Intraocular Pressure Changes Following Glucosamine Use: A Meta-Analysis of Pre-P
→ The use of glucosamine has increased in recent dec
CRD42023472857 Efficacy of glucosamine in temporomandibular joint osteoarthritis- Systematic re
→ Temporomandibular joint osteoarthiritis

📚 PubMed References

1 · cited research
PMID 31204557 Glucosamine promotes hepatitis B virus replication through its dual effects in s
Autophagy
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables