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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Glutathion

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Glutathion

Parkinson's Disease 3 Cystic Fibrosis 3 Healthy 2 Periorbital Hypermelanosis 1 Autism|Severe Behavior Disorder 1 To deliver a meticulous summary of all interventions conduct 1 Parkinson's Disease (PD) 1 Alcohol Drinking 1 Cirrhosis is characterized by fibrosis and nodule formation 1 Autism Spectrum Disorder as defined by the DSM (the Diagnost 1 Obesity|Hyperlipidemia|Insulin Resistance|Hypertension 1 Type 2 Diabetes|Oxidative Stress|Mitochondrial Reactive Oxyg 1

📋 Sample Trials

NCT00127309

Effect of Glutathione on Blood Alcohol and Hangover Symptoms

Completed

NCT00227058

Effects of Orotic Acid Derivatives With or Without Glutathione on Allergic Rhinitis

Completed

NCT00506688

Efficacy and Safety Study of Inhaled Glutathione in Cystic Fibrosis Patients

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42019121629

The effectiveness and safety of glutathione in treating Autism Spectrum Disorder

Autism Spectrum Disorder as defined by the DSM (the Diagnostic and Statistical M

CRD42019122983

The effectiveness and safety of glutathione in treating Autism Spectrum Disorder-relevant behaviors in animals

CRD42020185587

A meta-analysis of the association between glutathione S-transferase gene polymorphisms and the risk of liver cirrhosis

Cirrhosis is characterized by fibrosis and nodule formation of the liver, second

📚 Sample References

PMID 33309544

Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells

Chem Biol Interact · 2021

PMID 33422675

The use of glutathione to reduce oxidative stress status and its potential for modifying the extracellular matrix organization in cleft lip

Free Radic Biol Med · 2021

PMID 34150674

Effects of Oral Liposomal Glutathione in Altering the Immune Responses Against Mycobacterium tuberculosis and the Mycobacterium bovis BCG Strain in Individuals With Type 2 Diabetes

Front Cell Infect Microbiol · 2021

⚗️ All Ingredient data fields for Glutathion

⚗️ Identity

Name

Glutathion

Aliases / Synonyms

glutathione; 70-18-8; L-Glutathione; L-Glutathione reduced; Isethion; Tathion; Glutathione-SH; Glutinal; Tathione

🧪 Chemistry

Molecular Weight

307.3280

LogP

-2.2061

Drug-likeness

0.263

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N

Isomeric SMILES

C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N

InChIKey

RWSXRVCMGQZWBV-WDSKDSINSA-N

InChI

InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

🔗 External References

HERB DB

HBIN028061 ↗

PubChem CID

124886 ↗

HIT

C0106

TCMID

24495

🔍 Raw view — every non-empty column on this row (28 fields)

name

Glutathion

common names

glutathione; 70-18-8; L-Glutathione; L-Glutathione reduced; Isethion; Tathion; Glutathione-SH; Glutinal; Tathione

herb ingredient id

HBIN028061

canonical smiles

C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N

isomeric smiles

C(CC(=O)N[C@@H](CS)C(=O)NCC(=O)O)[C@@H](C(=O)O)N

inchi

InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1

inchikey

RWSXRVCMGQZWBV-WDSKDSINSA-N

mol wt

307.3280

num h acceptors

num h donors

mol logp

-2.2061

num rotatable bonds

drug likeness

0.263

tcmid ingredient id

24495

pubchem cid

124886

hit id

C0106

🏥 Linked Health Topics

2 · studied for these conditions (text bridge)

📋 Clinical Trials

12 · subject of clinical study

NCT00127309 Effect of Glutathione on Blood Alcohol and Hangover Symptoms

→ Alcohol Drinking

NCT00227058 Effects of Orotic Acid Derivatives With or Without Glutathione on Allergic Rhini

→ Seasonal Allergic Rhinitis

NCT00506688 Efficacy and Safety Study of Inhaled Glutathione in Cystic Fibrosis Patients

→ Cystic Fibrosis

NCT00889538 Study of Glutathione, Vitamin C and Cysteine in Children With Autism and Severe

→ Autism|Severe Behavior Disorder

NCT00910442 Glutathione and Its Precursors in HIV-Infected Patients

→ HIV Infection

NCT01016080 Role of Oral Glutathione in Skin Whitening

→ Skin Whitening

NCT01177319 Glutathione (GSH) In The Treatment of Parkinson's Disease

→ Parkinson's Disease

NCT01398748 Intranasal Glutathione in Parkinson's Disease

→ Parkinson's Disease (PD)

NCT01402570 Glutathione and Health With Post-Polio Syndrome

→ Post-polio Syndrome|Physical Activity|Depression|P

NCT01550432 Effects of Glutathione (an Antioxidant) and N-Acetylcysteine on Inflammation

→ Obesity|Hyperlipidemia|Insulin Resistance|Hyperten

NCT01967667 Biological Evaluation of Dietary Supplement Liposomal Glutathione

→ Schizophrenia

NCT02029521 Supplementation of Oral Reduced Glutathione in Pediatric Cystic Fibrosis Patient

→ Cystic Fibrosis

📊 Meta-Analyses

4 · systematic review

CRD42019121629 The effectiveness and safety of glutathione in treating Autism Spectrum Disorder

→ Autism Spectrum Disorder as defined by the DSM (th

CRD42019122983 The effectiveness and safety of glutathione in treating Autism Spectrum Disorder

CRD42020185587 A meta-analysis of the association between glutathione S-transferase gene polymo

→ Cirrhosis is characterized by fibrosis and nodule

CRD42023403839 Acquired Lip Hyperpigmentation Treatments: a systematic review and meta analysis

→ To deliver a meticulous summary of all interventio

📚 PubMed References

4 · cited research

PMID 33309544 Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel a

Chem Biol Interact

PMID 33422675 The use of glutathione to reduce oxidative stress status and its potential for m

Free Radic Biol Med

PMID 34150674 Effects of Oral Liposomal Glutathione in Altering the Immune Responses Against M

Front Cell Infect Microbiol

PMID 34707288 SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

Nature

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables