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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Glycyrrhizic acid

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Glycyrrhizic acid

Chronic hepatitis B is a common infectious disease, with a l 1 Autoimmune Liver Disease 1 Since the first outbreak of Coronavirus disease 2019(COVID-1 1

📋 Sample Trials

NCT04028869

Clinical Observation of Long-term Efficacy and Safety of Glycyrrhizic Acid Preparation in the Therapy of Autoimmune Liver Disease

Completed

📊 Sample Meta-Analyses

CRD42021234647

Clinical efficacy and security of glycyrrhizic acid preparation in the treatment of anti-SARS-CoV-2 drug-induced liver injury: a protocol of systematic review and meta-analysis

Since the first outbreak of Coronavirus disease 2019(COVID-19) in Wuhan, China a

CRD42022351351

Comparative efficacy and safety of different glycyrrhizic acid preparations combined with entecavir on chronic hepatitis B: a network meta-analysis

Chronic hepatitis B is a common infectious disease, with a long course of more t

📚 Sample References

PMID 22589456

Glycyrrhizic acid suppresses Cox-2-mediated anti-inflammatory responses during Leishmania donovani infection

J Antimicrob Chemother · 2012

PMID 33935702

Glycyrrhizic Acid Promotes Osteogenic Differentiation of Human Bone Marrow Stromal Cells by Activating the Wnt/β-Catenin Signaling Pathway

Front Pharmacol · 2021

PMID 34302803

Glycyrrhizic acid suppresses early stage of adipogenesis through repression of MEK/ERK-mediated C/EBPβ and C/EBPδ expression in 3T3-L1 cells

Chem Biol Interact · 2021

⚗️ All Ingredient data fields for Glycyrrhizic acid

⚗️ Identity

Name

Glycyrrhizic acid

Aliases / Synonyms

glycyrrhizin; 1405-86-3; Glycyron; Glycyrrhizinic acid; Glycyrrhetinic acid glycoside; potenlini; Glizigen; glycyrrhizate; glyzyrrhizin

🧪 Chemistry

Molecular Weight

822.9420

LogP

2.2456

Drug-likeness

0.171

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C

Isomeric SMILES

C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O

InChIKey

LPLVUJXQOOQHMX-QWBHMCJMSA-N

InChI

InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1

🔗 External References

HERB DB

HBIN028190 ↗

PubChem CID

14982 ↗

CAS Number

1405-86-3 ↗

TCMID

23251; 8845

TCM-ID

3938

🔍 Raw view — every non-empty column on this row (29 fields)

name

Glycyrrhizic acid

common names

glycyrrhizin; 1405-86-3; Glycyron; Glycyrrhizinic acid; Glycyrrhetinic acid glycoside; potenlini; Glizigen; glycyrrhizate; glyzyrrhizin

herb ingredient id

HBIN028190

canonical smiles

CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C

isomeric smiles

C[C@]12CC[C@](C[C@H]1C3=CC(=O)[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O[C@@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)C(=O)O)O)O)O)C)(C)C(=O)O

inchi

inchikey

LPLVUJXQOOQHMX-QWBHMCJMSA-N

mol wt

822.9420

num h acceptors

num h donors

mol logp

2.2456

num rotatable bonds

drug likeness

0.171

cas id

1405-86-3

tcmid ingredient id

23251; 8845

tcm id ingredient id

3938

pubchem cid

14982

🏥 Linked Health Topics

1 · diseases via target pathways

Autoimmune Liver Disease

syndrome

📋 Clinical Trials

1 · subject of clinical study

NCT04028869 Clinical Observation of Long-term Efficacy and Safety of Glycyrrhizic Acid Prepa

→ Autoimmune Liver Disease

📊 Meta-Analyses

2 · systematic review

CRD42021234647 Clinical efficacy and security of glycyrrhizic acid preparation in the treatment

→ Since the first outbreak of Coronavirus disease 20

CRD42022351351 Comparative efficacy and safety of different glycyrrhizic acid preparations comb

→ Chronic hepatitis B is a common infectious disease

📚 PubMed References

6 · cited research

PMID 22589456 Glycyrrhizic acid suppresses Cox-2-mediated anti-inflammatory responses during L

J Antimicrob Chemother

PMID 33935702 Glycyrrhizic Acid Promotes Osteogenic Differentiation of Human Bone Marrow Strom

Front Pharmacol

PMID 34302803 Glycyrrhizic acid suppresses early stage of adipogenesis through repression of M

Chem Biol Interact

PMID 34747319 Glycyrrhizic acid exhibits strong anticancer activity in colorectal cancer cells

Bioengineered

PMID 35237151 Transcriptome and Lipid Metabolomics-Based Discovery: Glycyrrhizic Acid Alleviat

Front Pharmacol

PMID 36422270 Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver In

Metabolites

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables