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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Hesperidin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Hesperidin

Diabetes results from heterogeneous group of metabolic disor 1 Covid19|Anosmia|Fever|Cough|Shortness of Breath|Sore Throat| 1 Cardiovascular risk biomarkers. 1 Bioequivalence 1 arthritis, Alzheimer’s, cancer, cardiovascular disease, diab 1 Venous Insufficiency 1 Rheumatoid Arthritis 1 PreDiabetes 1 Osteoporosis, Postmenopausal 1 Systemic inflammation plays an important role in development 1 Osteoporosis, Osteopenia 1 insufficiency venous 1

📋 Sample Trials

NCT03737422

The Effects of Hesperidin and Flaxseed in Prediabetes

Completed

NCT03471910

Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency

Completed · Phase 4

NCT05158192

Bioavailability of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to Reference Product

Completed · Phase 1

📊 Sample Meta-Analyses

CRD42017078018

Systematic review and meta-analysis of efficacy of diosmin and hesperidin versus aminftones in inflammatory mediators levels decrease and pain scale in chronic venous insufficiency treatment.

insufficiency venous

CRD42017058859

Effects of hesperidin and orange juice supplementation on glycemic control: a systematic review and meta-analysis of clinical trials

Diabetes results from heterogeneous group of metabolic disorders which is closel

CRD42017059923

Effects of hesperidin and orange juice supplementation on inflammatory markers: a systematic review and meta-analysis of clinical trials

Systemic inflammation plays an important role in development of several chronic

📚 Sample References

PMID 25047426

Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis

Eur J Cancer · 2014

PMID 32522593

Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat

Biochem Pharmacol · 2020

PMID 32655759

Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

Oxid Med Cell Longev · 2020

⚗️ All Ingredient data fields for Hesperidin

⚗️ Identity

Name

Hesperidin

Aliases / Synonyms

520-26-3; Cirantin; Hesperidoside; Hesper bitabs; Hesperetin 7-rhamnoglucoside; Hesperetin-rutinosid; Hesperidine; Hesperetin 7-rutinoside; Ciratin

🧪 Chemistry

Molecular Weight

610.5650

LogP

-1.1566

Drug-likeness

0.185

Oral Bioavailability

13.3350

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

Isomeric SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

InChIKey

QUQPHWDTPGMPEX-QJBIFVCTSA-N

InChI

InChI=1S/C28H34O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-7,10,17,19,21-30,32-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

🔗 External References

HERB DB

HBIN029196 ↗

PubChem CID

10621 ↗

CAS Number

520-26-3 ↗

SymMap

275

TCMID

9457

TCMSP

MOL007930

TCM-ID

3769

🔍 Raw view — every non-empty column on this row (32 fields)

name

Hesperidin

common names

520-26-3; Cirantin; Hesperidoside; Hesper bitabs; Hesperetin 7-rhamnoglucoside; Hesperetin-rutinosid; Hesperidine; Hesperetin 7-rutinoside; Ciratin

herb ingredient id

HBIN029196

canonical smiles

CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

isomeric smiles

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

inchi

inchikey

QUQPHWDTPGMPEX-QJBIFVCTSA-N

mol wt

610.5650

num h acceptors

num h donors

mol logp

-1.1566

num rotatable bonds

drug likeness

0.185

ob score

13.3350

cas id

520-26-3

symmap mol id

275

tcmid ingredient id

9457

tcmsp ingredient id

MOL007930

tcm id ingredient id

3769

pubchem cid

10621

🏥 Linked Health Topics

3 · diseases via target pathways

Rheumatoid Arthritis

syndrome

Osteoporosis, Postmenopausal

syndrome

Venous Insufficiency

syndrome

📋 Clinical Trials

10 · subject of clinical study

NCT03737422 The Effects of Hesperidin and Flaxseed in Prediabetes

→ PreDiabetes

NCT03471910 Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in S

→ Venous Insufficiency

NCT05158192 Bioavailability of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to Ref

→ Bioequivalence

NCT00330096 Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopau

→ Osteoporosis, Osteopenia

NCT00545116 Effects of Hesperidin on Bone Biomarkers in Postmenopausal Women

→ Osteopenia|Osteoporosis

NCT01881204 Hesperidin and Bone Health in Postmenopausal Women

→ Osteoporosis, Postmenopausal

NCT02610491 The Effect of Hesperidin on Glucose / Insulin Metabolism

→ Metabolic Syndrome|Obesity

NCT04715932 Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN)

NCT05243238 Hesperidin and Diosmin Effect on Metabolic Syndrome

→ Metabolic Syndrome and Diabetic Neuropathy

NCT05756179 Effect of Diosmin and Hesperidin in Treatment of Patients with Rheumatoid Arthri

→ Rheumatoid Arthritis

📊 Meta-Analyses

7 · systematic review

CRD42017078018 Systematic review and meta-analysis of efficacy of diosmin and hesperidin versus

→ insufficiency venous

CRD42017058859 Effects of hesperidin and orange juice supplementation on glycemic control: a sy

→ Diabetes results from heterogeneous group of metab

CRD42017059923 Effects of hesperidin and orange juice supplementation on inflammatory markers:

→ Systemic inflammation plays an important role in d

CRD42017058191 The effect of hesperidin supplementation and orange juice on lipid profile and b

→ Dyslipidemia and hypertension are known as a main

CRD42018088942 Effects of hesperidin on cardiovascular risk biomarkers: a systematic review of

→ Cardiovascular risk biomarkers.

CRD42020162376 The impact hesperidin consumption from 100% orange juice has on chronic diseases

→ arthritis, Alzheimer’s, cancer, cardiovascular dis

CRD42022325775 Hesperidin intervention and cardiovascular risk factors: systematic review and m

→ In this review the effect of hesperidin on cardiov

📚 PubMed References

12 · cited research

PMID 25047426 Hesperidin induces apoptosis and triggers autophagic markers through inhibition

Eur J Cancer

PMID 32522593 Neuroprotective effects of hesperidin against methotrexate-induced changes in ne

Biochem Pharmacol

PMID 32655759 Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticul

Oxid Med Cell Longev

PMID 32800830 Hesperidin protects against cadmium-induced pancreatitis by modulating insulin s

Life Sci

PMID 32916895 Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via

Antioxidants (Basel)

PMID 32922291 The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on t

Front Pharmacol

PMID 32982741 The Antidepressant-Like Effects of Hesperidin in Streptozotocin-Induced Diabetic

Front Pharmacol

PMID 33050842 The effect of hesperidin and luteolin isolated from Eriocephalus africanus on ap

J Biomol Struct Dyn

PMID 34422219 Naringin and Hesperidin Counteract Diclofenac-Induced Hepatotoxicity in Male Wis

Oxid Med Cell Longev

PMID 34444960 Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection

Nutrients

PMID 34530017 Protective effects of hesperidin through attenuation of Ki67 expression against

Life Sci

PMID 34721041 Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Triox

Front Pharmacol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables