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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Herb

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🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Fufang Danshen Dripping Pills; Comp Dajian Zhong Decoction; Da Jian Zho Shen Fu Injection Danggui Buxue Decoction; Dang Gui B Xiao Chai Hu Decoction Huangqi Guizhi Wuwu Decoction; Huan Xue Fu Zhu Yu Capsule; Xuefu Zhuyu Tian Wang Bu Xin Dan Ren Shen Yang Rong Decoction An Gong Niu Huang Pill; Angong Niuh

📜 Formula

Kaixin Powder; Kai Xin Powder

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Kaixin Powder; Kai Xin Powder

Depression is a common psychiatric disease with crucial feat 1 Alzheimer's disease. Alzheimer’s disease (AD) is by far the 1

📋 Sample Trials

None linked yet.

📊 Sample Meta-Analyses

CRD42020167155

Effectiveness and safety comparisons of Chinese herbal medicines for Alzheimer’s disease: a Bayesian network meta-analysis

Alzheimer's disease. Alzheimer’s disease (AD) is by far the most common form of

CRD42023403252

A meta-analysis of the efficacy and safety of traditional Chinese medicine formula Kaixinsan decoction for depression

Depression is a common psychiatric disease with crucial features of depressed mo

📚 Sample References

PMID 28553348

Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation

Neural Regen Res · 2017

PMID 30688265

Kai Xin San ameliorates scopolamine-induced cognitive dysfunction

Neural Regen Res · 2019

PMID 31354916

Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway

Oxid Med Cell Longev · 2019

📜 All Formula data fields for Kaixin Powder; Kai Xin Powder

📜 Names

Pinyin Name

KAI XIN SAN

中文名 (Chinese)

开心散

English Name

Kaixin Powder; Kai Xin Powder

💊 Form & Use

🌿 Related Herbs

9 · contains this compound

Root of Divaricate Saposhnikovia; Divaricate Saposhnikovia Root

Fang Feng

Root of Fourstamen Stephania; Fourstamen Stephania Root

Fang Ji

Liquorice Root; Root of Ural Licorice

Gan Cao

Baical Skullcap Root; Root of Baikal Skullcap

Common Peony (Wild) Equivalent Plant: Paeonia Obovata, Paeonia Veitchii

Shao Yao

Fresh Ginger

Sheng Jiang

Apricot Seed Equivalent Plant: Prunus Armeniaca Var Ansu

Xing Ren

⚗️ Related Ingredients

29 · compounds in this herb

4-(2-docosyloxycarbonyl-vinyl)-benzoic,acid

PubChem CID 101237996

4-(2-eicosyloxycarbonyl-vinyl)-benzoic,acid

PubChem CID 101237995

Beta-sitosterol

PubChem CID 222284

Campest-5-en-3beta-ol

PubChem CID 171336773

Mahuannin j

PubChem CID 171336776

24-Ethylcholest-4-en-3-one

poriferast-5-en-3beta-ol

🧬 Gene / Protein Targets

30 · gene targets via constituent compounds

KCNH2

Gene KCNH2

PGR

Gene PGR

NCOA2

Gene NCOA2

Prostaglandin G/H synthase 1

Prostaglandin G/H synthase 2

Heat shock protein HSP 90

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform

Gamma-aminobutyric-acid receptor alpha-2 subunit

Muscarinic acetylcholine receptor M2

Gamma-aminobutyric acid receptor subunit alpha-1

mRNA of PKA Catalytic Subunit C-alpha

Muscarinic acetylcholine receptor M1

Alpha-1B adrenergic receptor

Apoptosis regulator Bcl-2

Apoptosis regulator BAX

Transcription factor AP-1

Caspase-3

Sodium channel protein type 5 subunit alpha

Beta-2 adrenergic receptor

Caspase-9

Caspase-8

Protein kinase C alpha type

Transforming growth factor beta-1

Serum paraoxonase/arylesterase 1

Dopamine D1 receptor

Muscarinic acetylcholine receptor M3

Muscarinic acetylcholine receptor M4

CGMP-inhibited 3',5'-cyclic phosphodiesterase A

5-hydroxytryptamine 2A receptor

Gamma-aminobutyric-acid receptor alpha-5 subunit

🏥 Linked Health Topics

30 · diseases via target pathways

Squamous Cell Carcinoma

disease

Carpal Tunnel Syndrome

Coronary Heart Disease

Disseminated Intravascular Coagulation

Endometrial Neoplasms

📊 Meta-Analyses

2 · systematic review

CRD42020167155 Effectiveness and safety comparisons of Chinese herbal medicines for Alzheimer’s

→ Alzheimer's disease. Alzheimer’s disease (AD) is b

CRD42023403252 A meta-analysis of the efficacy and safety of traditional Chinese medicine formu

→ Depression is a common psychiatric disease with cr

📚 PubMed References

8 · cited research

PMID 28553348 Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-de

Neural Regen Res

PMID 30688265 Kai Xin San ameliorates scopolamine-induced cognitive dysfunction

Neural Regen Res

PMID 31354916 Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effecti

Oxid Med Cell Longev

PMID 32317964 Systems Pharmacology Approach to Investigate the Mechanism of Kai-Xin-San in Alz

Front Pharmacol

PMID 32973539 Behavioral and Biochemical Effects of KXS on Postmyocardial Infarction Depressio

Front Pharmacol

PMID 33790789 Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-I

Front Pharmacol

PMID 34306310 Mitochondrial Protection and Against Glutamate Neurotoxicity via Shh/Ptch1 Signa

Oxid Med Cell Longev

PMID 34735906 Novel insights into antidepressant mechanism of Kai Xin San formula: Inhibiting

Phytomedicine

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables