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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Histamine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Histamine

Pruritus 2 Scombroid syndrome/histamine poisoning occurs worldwide and 1 Acute Myeloid Leukemia 1 Prevention of stress ulcers in pediatric intensive care unit 1 Over the last two decades antipsychotics are increasingly pr 1 Histamine-2 receptor antagonists (H2RA) are frequently presc 1 Functional dyspepsia (FD) is a common gastrointestinal disor 1 Cough, no matter the etiology. 1 Asthma 1 As the use of gastric acid suppressants such as proton pump 1 Antihistamine-refractory CSU. 1 Allergic rhinitis is a common disease characterised by nasal 1

📋 Sample Trials

NCT04399213

Dermal Blood Flow Response to Escalating Doses of Histamine, Administered by a Skin Prick

Completed

NCT04396977

Inter-arm and Inter-period Reproducability of the Dermal Blood Flow Response After a Histamine Skin Prick.

Completed

NCT01347996

Maintenance Therapy With Ceplene® (Histamine) and IL-2 on Immune Response and MRD in Acute Myeloid Leukemia

Completed · Phase 4

📊 Sample Meta-Analyses

CRD42020196592

Comparative Effectiveness and Acceptability of Treatments for Antihistamine-Refractory Chronic Spontaneous Urticaria: A Network Meta-Analysis of Randomized Controlled Trials and Observational Studies

Antihistamine-refractory CSU.

CRD42012002566

Histamine food poisonings: a systematic review and meta-analysis

Scombroid syndrome/histamine poisoning occurs worldwide and it is considered one

CRD42014007115

Comparative effectiveness of intranasal steroids, leukotriene antagonists, decongestant, and second generation Histamine H1 Antagonists in allergic rhinitis of adults: systematic review and network meta-analysis

Allergic rhinitis is a common disease characterised by nasal itch, sneezing, rhi

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Histamine

⚗️ Identity

Name

Histamine

Aliases / Synonyms

51-45-6; 2-(1H-imidazol-5-yl)ethanamine; 1H-Imidazole-4-ethanamine; Ergamine; Ergotidine; 2-(4-Imidazolyl)ethylamine; 5-Imidazoleethylamine; Eramin; Theramine

🧪 Chemistry

Molecular Weight

111.1480

LogP

-0.0891

Drug-likeness

0.56

Oral Bioavailability

44.1040

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=C(NC=N1)CCN

Isomeric SMILES

C1=C(NC=N1)CCN

InChIKey

NTYJJOPFIAHURM-UHFFFAOYSA-N

InChI

InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)

🔗 External References

HERB DB

HBIN029438 ↗

PubChem CID

774 ↗

CAS Number

51-45-6 ↗

NPASS

NPC111132

HIT

C0125

SymMap

108

TCMID

9567

TCMSP

MOL001464

TCM-ID

3708

🔍 Raw view — every non-empty column on this row (34 fields)

name

Histamine

common names

51-45-6; 2-(1H-imidazol-5-yl)ethanamine; 1H-Imidazole-4-ethanamine; Ergamine; Ergotidine; 2-(4-Imidazolyl)ethylamine; 5-Imidazoleethylamine; Eramin; Theramine

herb ingredient id

HBIN029438

canonical smiles

C1=C(NC=N1)CCN

isomeric smiles

C1=C(NC=N1)CCN

inchi

InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)

inchikey

NTYJJOPFIAHURM-UHFFFAOYSA-N

mol wt

111.1480

num h acceptors

num h donors

mol logp

-0.0891

num rotatable bonds

drug likeness

0.56

ob score

44.1040

cas id

51-45-6

symmap mol id

108

tcmid ingredient id

9567

tcmsp ingredient id

MOL001464

tcm id ingredient id

3708

pubchem cid

774

npass id

NPC111132

hit id

C0125

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Pruritus

phenotype

📋 Clinical Trials

3 · subject of clinical study

NCT04399213 Dermal Blood Flow Response to Escalating Doses of Histamine, Administered by a S

→ Pruritus

NCT04396977 Inter-arm and Inter-period Reproducability of the Dermal Blood Flow Response Aft

→ Pruritus

NCT01347996 Maintenance Therapy With Ceplene® (Histamine) and IL-2 on Immune Response and MR

→ Acute Myeloid Leukemia

📊 Meta-Analyses

10 · systematic review

CRD42020196592 Comparative Effectiveness and Acceptability of Treatments for Antihistamine-Refr

→ Antihistamine-refractory CSU.

CRD42012002566 Histamine food poisonings: a systematic review and meta-analysis

→ Scombroid syndrome/histamine poisoning occurs worl

CRD42014007115 Comparative effectiveness of intranasal steroids, leukotriene antagonists, decon

→ Allergic rhinitis is a common disease characterise

CRD42017060887 Is histamine-2 receptor antagonists use a risk factor for infection, necrotizing

→ Histamine-2 receptor antagonists (H2RA) are freque

CRD42018093606 The risk of community-acquired pneumonia in children using proton pump inhibitor

→ As the use of gastric acid suppressants such as pr

CRD42019124528 Efficacy of histamine antagonist antitussive agents versus placebo in symptomati

→ Cough, no matter the etiology.

CRD42019127924 Histamine H2 antagonists for functional dyspepsia: a systematic review and meta-

→ Functional dyspepsia (FD) is a common gastrointest

CRD42019130934 Reassessing the use of proton pump inhibitors and histamine-2 antagonists in cri

→ Prevention of stress ulcers in pediatric intensive

CRD42020150055 The efficacy and safety of histamine H3 antagonists in controlling antipsychotic

→ Over the last two decades antipsychotics are incre

CRD42023438302 Accuracy of bronchial challenge testing with histamine and methacholine in the d

→ Asthma

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables