Relationship Graph Explorer

Follow the connections

Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

🌿

Herb

→

→

→

→

🧪

Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

H-met-h

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with H-met-h

Patients with glioma that have undergone a MET PET study. 1 Brain Tumors and/or Solid Tumors Including|Brain Stem Glioma 1 Multiple myeloma, accounting for approximately 10% of hemato 1 Brain Cancer|CNS Cancer 1 Lung cancer is the most common cancer and a leading cause of 1 Breast cancer risk 1 Urinary Tract Infection|Pelvic Organ Prolapse|Urinary Incont 1 Unipolar Depression 1 Pulmonary Alveolar Proteinosis|Mutation Ala393Thr of the MAR 1 Pregnancy Related 1 Myelopathy|AIDS-Myelopathy|AIDS Vacuolar Myelopathy 1 Metabolic Syndrome 1

📋 Sample Trials

NCT00032695

Treatment of AIDS Vacuolar Myelopathy With Methionine

Completed · Phase 3

NCT00597246

Imaging Brain Tumors With FACBC and Methionine

Completed

NCT00840047

Methionine PET/CT Studies In Patients With Cancer

Active_Not_Recruiting · Phase 2

📊 Sample Meta-Analyses

CRD42019123111

The association between dietary intakes of methionine, choline and betaine and breast cancer risk: a systematic review and meta-analysis

Breast cancer risk

CRD42015019955

S-adenosyl methionine (SAM-e) for depression in adults [Cochrane Protocol]

The Cochrane Depression, Anxiety and Neurosis Group

CRD42020195977

Performance of 11C-methionine PET imaging for detecting multiple myeloma

Multiple myeloma, accounting for approximately 10% of hematological malignancies

📚 Sample References

PMID 31961063

Methionine Commits Cells to Differentiate Into Plasmablasts Through Epigenetic Regulation of BTB and CNC Homolog 2 by the Methyltransferase EZH2

Arthritis Rheumatol · 2020

PMID 32160926

Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study

J Transl Med · 2020

PMID 32533465

Withdrawal Effects Following Methionine Exposure in Adult Zebrafish

Mol Neurobiol · 2020

⚗️ All Ingredient data fields for H-met-h

⚗️ Identity

Name

H-met-h

Aliases / Synonyms

L-methionine; 63-68-3; methionine; h-Met-oh; (S)-2-Amino-4-(methylthio)butanoic acid; Cymethion; L-(-)-Methionine; S-Methionine; Liquimeth; Neo-methidin

🧪 Chemistry

Molecular Weight

149.2150

LogP

0.1514

Drug-likeness

0.597

Oral Bioavailability

70.8660

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CSCCC(C(=O)O)N

Isomeric SMILES

CSCC[C@@H](C(=O)O)N

InChIKey

FFEARJCKVFRZRR-BYPYZUCNSA-N

InChI

InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

🔗 External References

HERB DB

HBIN029443 ↗

PubChem CID

6137 ↗

CAS Number

26062-47-5 ↗

SymMap

7204

TCMSP

MOL005449

🔍 Raw view — every non-empty column on this row (30 fields)

name

H-met-h

common names

L-methionine; 63-68-3; methionine; h-Met-oh; (S)-2-Amino-4-(methylthio)butanoic acid; Cymethion; L-(-)-Methionine; S-Methionine; Liquimeth; Neo-methidin

herb ingredient id

HBIN029443

canonical smiles

CSCCC(C(=O)O)N

isomeric smiles

CSCC[C@@H](C(=O)O)N

inchi

InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

inchikey

FFEARJCKVFRZRR-BYPYZUCNSA-N

mol wt

149.2150

num h acceptors

num h donors

mol logp

0.1514

num rotatable bonds

drug likeness

0.597

ob score

70.8660

cas id

26062-47-5

symmap mol id

7204

tcmsp ingredient id

MOL005449

pubchem cid

6137

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Unipolar Depression

disease

📋 Clinical Trials

9 · subject of clinical study

NCT00032695 Treatment of AIDS Vacuolar Myelopathy With Methionine

→ Myelopathy|AIDS-Myelopathy|AIDS Vacuolar Myelopath

NCT00597246 Imaging Brain Tumors With FACBC and Methionine

→ Brain Cancer|CNS Cancer

NCT00840047 Methionine PET/CT Studies In Patients With Cancer

→ Brain Tumors and/or Solid Tumors Including|Brain S

NCT02216253 L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract to Prevent Postoper

→ Urinary Tract Infection|Pelvic Organ Prolapse|Urin

NCT02566434 Methionine Tolerance in Healthy Human Adults

→ Healthy

NCT03887169 Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by

→ Pulmonary Alveolar Proteinosis|Mutation Ala393Thr

NCT04326322 Methionine Requirements During Healthy Human Pregnancy

→ Pregnancy Related

NCT00226356 Natural Supplements for Unipolar Depression

→ Unipolar Depression

NCT00640757 Methionine-Restriction Diet (MRD) in Obese Adults With Metabolic Syndrome

→ Metabolic Syndrome

📊 Meta-Analyses

5 · systematic review

CRD42019123111 The association between dietary intakes of methionine, choline and betaine and b

→ Breast cancer risk

CRD42015019955 S-adenosyl methionine (SAM-e) for depression in adults [Cochrane Protocol]

→ The Cochrane Depression, Anxiety and Neurosis Grou

CRD42020195977 Performance of 11C-methionine PET imaging for detecting multiple myeloma

→ Multiple myeloma, accounting for approximately 10%

CRD42018086654 Serum B vitamins (B6, B9, B12), homocysteine and methionine—involved in one-carb

→ Lung cancer is the most common cancer and a leadin

CRD42016050747 11C-methionine PET in the discrimination between low-grade glioma and high-grade

→ Patients with glioma that have undergone a MET PET

📚 PubMed References

7 · cited research

PMID 31961063 Methionine Commits Cells to Differentiate Into Plasmablasts Through Epigenetic R

Arthritis Rheumatol

PMID 32160926 Effects of dietary methionine and cysteine restriction on plasma biomarkers, ser

J Transl Med

PMID 32533465 Withdrawal Effects Following Methionine Exposure in Adult Zebrafish

Mol Neurobiol

PMID 32790060 Dietary methionine restriction attenuates renal ischaemia/reperfusion-induced my

J Cell Mol Med

PMID 32879489 Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

Nature

PMID 33207837 Methionine Supplementation Affects Metabolism and Reduces Tumor Aggressiveness i

Cells

PMID 33475949 Methionine Supplementation Abolishes Nicotine-Induced Place Preference in Zebraf

Mol Neurobiol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables