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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Hypericin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Hypericin

HIV Infections 2 Cutaneous T-Cell Lymphoma 1 Cutaneous T Cell Lymphoma|Mycosis Fungoides 1 Psoriasis|Plaque Psoriasis|Psoriasis Vulgaris 1 Cutaneous T-Cell Lymphoma/Mycosis Fungoides 1

📋 Sample Trials

NCT00000645

A Phase I Dose Escalation Study of Synthetic Hypericin in HIV-Infected Patients With Less Than 300 CD4 Lymphocytes

Completed · Phase 1

NCT00000792

A Pharmacologically Guided Phase I/II Study of Daily Orally Administered Synthetic Hypericin in HIV-Infected Subjects

Completed · Phase 1

NCT02448381

FLASH [Fluorescent Light Activated Synthetic Hypericin] Clinical Study: Topical SGX301 (Synthetic Hypericin) for the Treatment of Cutaneous T-Cell Lymphoma (Mycosis Fungoides)

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42022363626

Antimicrobial effects of hypericin and pseudohypericin: a systematic review.

📚 Sample References

PMID 34710555

Anti-fatigue effect of hypericin in a chronic forced exercise mouse model

J Ethnopharmacol · 2021

PMID 35101848

The protective effect of hypericin on postpartum depression rat model by inhibiting the NLRP3 inflammasome activation and regulating glucocorticoid metabolism

Int Immunopharmacol · 2022

PMID 35811028

Hypericin blocks the function of HSV-1 alkaline nuclease and suppresses viral replication

J Ethnopharmacol · 2022

⚗️ All Ingredient data fields for Hypericin

⚗️ Identity

Name

Hypericin

Aliases / Synonyms

548-04-9; Hypericum red; Cyclosan; hipericin; hipericina; hypericine; Mycoporphyrin; Hyperizin; Cyclo-Werol

🧪 Chemistry

Molecular Weight

504.4500

LogP

5.0810

Drug-likeness

0.123

Oral Bioavailability

14.6650

H-Bond Acceptors

H-Bond Donors

🔬 Structures

Canonical SMILES

CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O

Isomeric SMILES

CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O

InChIKey

YDOIFHVUBCIUHF-UHFFFAOYSA-N

InChI

InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,33-38H,1-2H3

🔗 External References

HERB DB

HBIN029828 ↗

PubChem CID

3663 ↗

CAS Number

548-04-9 ↗

SymMap

4377

TCMID

10885

TCMSP

MOL002067

TCM-ID

3624

🔍 Raw view — every non-empty column on this row (32 fields)

name

Hypericin

common names

548-04-9; Hypericum red; Cyclosan; hipericin; hipericina; hypericine; Mycoporphyrin; Hyperizin; Cyclo-Werol

herb ingredient id

HBIN029828

canonical smiles

CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O

isomeric smiles

CC1=CC(=O)C2=C(C3=C(C=C(C4=C3C5=C2C1=C6C(=CC(=O)C7=C(C8=C(C=C(C4=C8C5=C67)O)O)O)C)O)O)O

inchi

InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,33-38H,1-2H3

inchikey

YDOIFHVUBCIUHF-UHFFFAOYSA-N

mol wt

504.4500

num h acceptors

num h donors

mol logp

5.0810

num rotatable bonds

drug likeness

0.123

ob score

14.6650

cas id

548-04-9

symmap mol id

4377

tcmid ingredient id

10885

tcmsp ingredient id

MOL002067

tcm id ingredient id

3624

pubchem cid

3663

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Hiv Infections

group

📋 Clinical Trials

6 · subject of clinical study

NCT00000645 A Phase I Dose Escalation Study of Synthetic Hypericin in HIV-Infected Patients

→ HIV Infections

NCT00000792 A Pharmacologically Guided Phase I/II Study of Daily Orally Administered Synthet

→ HIV Infections

NCT02448381 FLASH [Fluorescent Light Activated Synthetic Hypericin] Clinical Study: Topical

→ Cutaneous T-Cell Lymphoma

NCT05442190 Topical SGX302 for Mild-to-Moderate Psoriasis

→ Psoriasis|Plaque Psoriasis|Psoriasis Vulgaris

NCT05872854 Treatment of Mycosis Fungoides With Hypericin Ointment and Visible Light

→ Cutaneous T Cell Lymphoma|Mycosis Fungoides

NCT06149247 HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment

→ Cutaneous T-Cell Lymphoma/Mycosis Fungoides

📊 Meta-Analyses

1 · systematic review

CRD42022363626 Antimicrobial effects of hypericin and pseudohypericin: a systematic review.

📚 PubMed References

3 · cited research

PMID 34710555 Anti-fatigue effect of hypericin in a chronic forced exercise mouse model

J Ethnopharmacol

PMID 35101848 The protective effect of hypericin on postpartum depression rat model by inhibit

Int Immunopharmacol

PMID 35811028 Hypericin blocks the function of HSV-1 alkaline nuclease and suppresses viral re

J Ethnopharmacol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables