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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Icariin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Icariin

the Pharmacokinetic Profile of Icariin in Humans 1 Bipolar Disorder|Substance Use Disorder 1 Thin endometrium is defined as <7 mm on the day of ovulat 1

📋 Sample Trials

NCT01979133

Study of Icariin for Bipolar Disorder and Co-Occurring Substance Use Disorders

Completed · Phase 3

NCT02112123

Icariin to Prevent Corticosteroid-related Memory Changes

Completed · Phase 1

📊 Sample Meta-Analyses

CRD42019148977

The effect of icariin for infertile women with thin endometrium: a systematic review and meta-analysis

Thin endometrium is defined as <7 mm on the day of ovulation, or on the day o

CRD42023412608

Protective effects of Icariin in nephropathy and possible mechanisms of action: a meta-analysis and systematic review of animal studies

CRD42023400169

Preclinical evidence for Icariin against Alzheimer's disease: a meta-analysis and systematic review

📚 Sample References

PMID 31943455

Icariin prevents oestrogen deficiency-induced alveolar bone loss through promoting osteogenesis via STAT3

Cell Prolif · 2020

PMID 31914584

Icariin and its phosphorylated derivatives alleviate intestinal epithelial barrier disruption caused by enterotoxigenic Escherichia coli through modulate p38 MAPK in vivo and in vitro

FASEB J · 2020

PMID 30051466

Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuating sirtuin 1-dependent mitochondrial oxidative damage

Br J Pharmacol · 2018

⚗️ All Ingredient data fields for Icariin

⚗️ Identity

Name

Icariin

Aliases / Synonyms

489-32-7; Ieariline; CHEBI:78420; UNII-VNM47R2QSQ; VNM47R2QSQ; 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; Icariine; Epimedii herba icariin; MFCD00210516

🧪 Chemistry

Molecular Weight

676.6680

LogP

0.0679

Drug-likeness

0.14

Oral Bioavailability

41.5830

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O

Isomeric SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O

InChIKey

TZJALUIVHRYQQB-XLRXWWTNSA-N

InChI

InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1

🔗 External References

HERB DB

HBIN029922 ↗

PubChem CID

5318997 ↗

CAS Number

489-32-7 ↗

NPASS

NPC5319

HIT

C0135

TCMID

23160

TCMSP

MOL004425

TCM-ID

3598

🔍 Raw view — every non-empty column on this row (33 fields)

name

Icariin

common names

herb ingredient id

HBIN029922

canonical smiles

CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O

isomeric smiles

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O

inchi

inchikey

TZJALUIVHRYQQB-XLRXWWTNSA-N

mol wt

676.6680

num h acceptors

num h donors

mol logp

0.0679

num rotatable bonds

drug likeness

0.14

ob score

41.5830

cas id

489-32-7

tcmid ingredient id

23160

tcmsp ingredient id

MOL004425

tcm id ingredient id

3598

pubchem cid

5318997

npass id

NPC5319

hit id

C0135

📋 Clinical Trials

2 · subject of clinical study

NCT01979133 Study of Icariin for Bipolar Disorder and Co-Occurring Substance Use Disorders

→ Bipolar Disorder|Substance Use Disorder

NCT02112123 Icariin to Prevent Corticosteroid-related Memory Changes

→ the Pharmacokinetic Profile of Icariin in Humans

📊 Meta-Analyses

4 · systematic review

CRD42019148977 The effect of icariin for infertile women with thin endometrium: a systematic re

→ Thin endometrium is defined as <7 mm on the day

CRD42023412608 Protective effects of Icariin in nephropathy and possible mechanisms of action:

CRD42023400169 Preclinical evidence for Icariin against Alzheimer's disease: a meta-analysi

CRD42023451564 The shared KEGG pathways between Icariin-targeted genes and Alzheimer's dise

📚 PubMed References

12 · cited research

PMID 31943455 Icariin prevents oestrogen deficiency-induced alveolar bone loss through promoti

Cell Prolif

PMID 31914584 Icariin and its phosphorylated derivatives alleviate intestinal epithelial barri

FASEB J

PMID 30051466 Icariin protects cardiomyocytes against ischaemia/reperfusion injury by attenuat

Br J Pharmacol

PMID 25787271 Icariin promotes angiogenic differentiation and prevents oxidative stress-induce

Stem Cells

PMID 25355404 Icariin attenuates hypoxia-induced oxidative stress and apoptosis in osteoblasts

Cell Prolif

PMID 32011040 Icariin inhibits proliferation, migration, and invasion of medulloblastoma DAOY

Phytother Res

PMID 32082160 Icariin Protects Hippocampal Neurons From Endoplasmic Reticulum Stress and NF-κB

Front Pharmacol

PMID 32124960 Icariin sensitizes human colon cancer cells to TRAIL‑induced apoptosis via ERK‑m

Int J Oncol

PMID 32265695 Icariin Ameliorates Diabetic Cardiomyopathy Through Apelin/Sirt3 Signalling to I

Front Pharmacol

PMID 32348838 Icariin protects rabbit BMSCs against OGD-induced apoptosis by inhibiting ERs-me

Life Sci

PMID 32470450 Icariin protects neurons from endoplasmic reticulum stress-induced apoptosis aft

Life Sci

PMID 32554031 Intranasal delivery of icariin via a nanogel-thermoresponsive hydrogel compound

Int J Pharm

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables