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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Indomethacin

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Indomethacin

Post-ERCP Acute Pancreatitis 3 The Cochrane Injuries Group 1 Studies have shown that indometachin is effective in the pre 1 Pancreatitis|Cholangiopancreatography, Endoscopic Retrograde 1 Spontaneous intestinal perforation (SIP) in preterm newborns 1 Prevention in patients undergoing ERCP 1 Post-ERCp pancreatitis 1 Pericarditis. Pericarditis is the condition where the perica 1 PDA in preterm infants 1 Patency of ductus arteriosus is essential during pregnancy f 1 obstetrics 1 With the development of endoscopic technology, ERCP is widel 1

📋 Sample Trials

NCT05664074

Rectal Indomethacin vs Intravenous Ketorolac

Recruiting · Phase 4

NCT05252754

Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis

Recruiting · Phase 3

NCT06031363

The Optimal Dose of Indomethacin Suppository for Preventing Post-ERCP Pancreatitis

Completed

📊 Sample Meta-Analyses

CRD42015015797

Systematic review and network meta-analysis of IV indomethacin versus IV Ibuprofen versus oral Ibuprofen versus oral acetaminophen versus placebo for treatment of symptomatic patent ductus arteriosus in preterm infants

Management of patent ductus arteriosus (PDA) in preterm infants is one of the mo

CRD42015027139

Indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury [Cochrane Protocol]

The Cochrane Injuries Group

CRD42016038397

Rectal Indomethacin Prevents Moderate to Severe Post- ERCP Pancreatitis and Death and Should Be Used Before the Procedure: A Meta-Analysis of Aggregate Subgroup Data

Post-ERCp pancreatitis

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Indomethacin

⚗️ Identity

Name

Indomethacin

Aliases / Synonyms

53-86-1; indometacin; Indocin; Indomethacine; Indometacine; Indocid; Reumacide; Indomethazine; Metindol

🧪 Chemistry

Molecular Weight

357.7930

LogP

3.9273

Drug-likeness

0.768

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Isomeric SMILES

CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

InChIKey

CGIGDMFJXJATDK-UHFFFAOYSA-N

InChI

InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

🔗 External References

HERB DB

HBIN030127 ↗

PubChem CID

3715 ↗

NPASS

NPC331672

TCM-ID

14037

🔍 Raw view — every non-empty column on this row (28 fields)

name

Indomethacin

common names

53-86-1; indometacin; Indocin; Indomethacine; Indometacine; Indocid; Reumacide; Indomethazine; Metindol

herb ingredient id

HBIN030127

canonical smiles

CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

isomeric smiles

CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

inchi

InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

inchikey

CGIGDMFJXJATDK-UHFFFAOYSA-N

mol wt

357.7930

num h acceptors

num h donors

mol logp

3.9273

num rotatable bonds

drug likeness

0.768

tcm id ingredient id

14037

pubchem cid

3715

npass id

NPC331672

📋 Clinical Trials

5 · subject of clinical study

NCT05664074 Rectal Indomethacin vs Intravenous Ketorolac

→ Post-ERCP Acute Pancreatitis

NCT05252754 Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP

→ Post-ERCP Acute Pancreatitis

NCT06031363 The Optimal Dose of Indomethacin Suppository for Preventing Post-ERCP Pancreatit

→ Pancreatitis|Cholangiopancreatography, Endoscopic

NCT05947461 Prevention of Post-ERCP Pancreatitis by Indomethacin vs Diclofenac

→ Post-ERCP Acute Pancreatitis|NSAIDs|Indomethacin|D

NCT05857514 Randomized Controlled Trial of Rectal Indomethacin Versus Combined Pancreatic St

→ Post-ERCP Acute Pancreatitis

📊 Meta-Analyses

12 · systematic review

CRD42015015797 Systematic review and network meta-analysis of IV indomethacin versus IV Ibuprof

→ Management of patent ductus arteriosus (PDA) in pr

CRD42015027139 Indomethacin in controlling intracranial hypertension secondary to severe trauma

→ The Cochrane Injuries Group

CRD42016038397 Rectal Indomethacin Prevents Moderate to Severe Post- ERCP Pancreatitis and Deat

→ Post-ERCp pancreatitis

CRD42016045415 When should indomethacin be used for preventing post-ERCP pancreatitis?

→ Prevention in patients undergoing ERCP

CRD42017058603 Association between use of indomethacin, ibuprofen and acetaminophen with sponta

→ Spontaneous intestinal perforation (SIP) in preter

CRD42018112698 Lactated Ringer's in combination with indomethacin for the prevention of pos

→ Studies have shown that indometachin is effective

CRD42019146012 Indomethacin for symptomatic patent ductus arteriosus in preterm infants [Cochra

→ The Cochrane Neonatal Group

CRD42020165457 A systematic literature review of meta-analyses for the treatment of patent duct

→ Patency of ductus arteriosus is essential during p

CRD42023456080 Colchicine for the Treatment of Pericarditis: A Meta-Analysis of Randomized Cont

→ Pericarditis. Pericarditis is the condition where

CRD42023400977 Expectant management of patent ductus arteriosus for preterm infants: a meta-ana

→ PDA in preterm infants

CRD42023401099 Role of cervical cerclage, indomethacin and antibiotics in twin pregnancies

→ obstetrics

CRD42023432192 The efficacy of Somatostatin versus its combination with Indomethacin in the pre

→ With the development of endoscopic technology, ERC

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables