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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Inosine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Inosine

Amyotrophic Lateral Sclerosis 1 Advanced Solid Tumor 1 The Cochrane Multiple Sclerosis and Rare Diseases of the CNS 1 Literature data concerning studies related to clinical appli 1 Parkinson's Disease 1 Parkinson Disease 1 Multiple Sclerosis, Relapsing-Remitting 1 Healthy Volunteers 1 Healthy 1

📋 Sample Trials

NCT02288091

A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS)

Completed · Phase 1

NCT00067327

Treatment of Multiple Sclerosis Using Over the Counter Inosine

Completed · Phase 2

NCT00833690

Safety of Urate Elevation in Parkinson's Disease

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42016033054

The efficacy of inosine pranobex in non-HIV and non-cancer clinical conditions

Literature data concerning studies related to clinical applications of Inosine p

CRD42017083037

Inosine for multiple sclerosis [Cochrane protocol]

The Cochrane Multiple Sclerosis and Rare Diseases of the CNS Group

📚 Sample References

PMID 33820558

Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

Microbiome · 2021

PMID 34792730

Investigating the Effect of Inosine on Brain Purinergic Receptors and Neurotrophic and Neuroinflammatory Parameters in an Experimental Model of Alzheimer's Disease

Mol Neurobiol · 2022

⚗️ All Ingredient data fields for Inosine

⚗️ Identity

Name

Inosine

Aliases / Synonyms

58-63-9; Hypoxanthosine; Ribonosine; Atorel; Oxiamin; Hypoxanthine riboside; Trophicardyl; Selfer; Pantholic-L

🧪 Chemistry

Molecular Weight

268.2290

LogP

-2.2689

Drug-likeness

0.482

Oral Bioavailability

11.1710

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)O

Isomeric SMILES

C1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

InChIKey

UGQMRVRMYYASKQ-KQYNXXCUSA-N

InChI

InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1

🔗 External References

HERB DB

HBIN030187 ↗

PubChem CID

135398641 ↗

CAS Number

58-63-9 ↗

NPASS

NPC79321

SymMap

667

TCMID

11079

TCMSP

MOL006948

🔍 Raw view — every non-empty column on this row (32 fields)

name

Inosine

common names

58-63-9; Hypoxanthosine; Ribonosine; Atorel; Oxiamin; Hypoxanthine riboside; Trophicardyl; Selfer; Pantholic-L

herb ingredient id

HBIN030187

canonical smiles

C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)O

isomeric smiles

C1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

inchi

InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1

inchikey

UGQMRVRMYYASKQ-KQYNXXCUSA-N

mol wt

268.2290

num h acceptors

num h donors

mol logp

-2.2689

num rotatable bonds

drug likeness

0.482

ob score

11.1710

cas id

58-63-9

symmap mol id

667

tcmid ingredient id

11079

tcmsp ingredient id

MOL006948

pubchem cid

135398641

npass id

NPC79321

🏥 Linked Health Topics

3 · studied for these conditions (text bridge)

Amyotrophic Lateral Sclerosis

syndrome

Parkinson Disease

syndrome

Multiple Sclerosis, Relapsing-Remitting

syndrome

📋 Clinical Trials

7 · subject of clinical study

NCT02288091 A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS)

→ Amyotrophic Lateral Sclerosis

NCT00067327 Treatment of Multiple Sclerosis Using Over the Counter Inosine

→ Multiple Sclerosis, Relapsing-Remitting

NCT00833690 Safety of Urate Elevation in Parkinson's Disease

→ Parkinson Disease

NCT02614469 A Food-Drug Interaction Study of Serum Urate After Oral Inosine

→ Healthy

NCT02642393 Study of Urate Elevation in Parkinson's Disease, Phase 3

→ Parkinson's Disease

NCT04476238 Inosine Energy Expenditure Study

→ Healthy Volunteers

NCT05809336 Gut Microbial Metabolites Inosine Combined With PD-1/PD-L1 Inhibitor for Patient

→ Advanced Solid Tumor

📊 Meta-Analyses

2 · systematic review

CRD42016033054 The efficacy of inosine pranobex in non-HIV and non-cancer clinical conditions

→ Literature data concerning studies related to clin

CRD42017083037 Inosine for multiple sclerosis [Cochrane protocol]

→ The Cochrane Multiple Sclerosis and Rare Diseases

📚 PubMed References

2 · cited research

PMID 33820558 Gut microbiota-derived inosine from dietary barley leaf supplementation attenuat

Microbiome

PMID 34792730 Investigating the Effect of Inosine on Brain Purinergic Receptors and Neurotroph

Mol Neurobiol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables