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trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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🌿 Herb

Cocoa

Open on HERB 2.0 ↗
38
Clinical Trials
15
Meta-Analyses
1
PubMed References
Top Conditions Studied with Cocoa
Healthy 3 Healthy Subjects 2 Cocoa supplementation associated to physical exercise on hea 2 Insulin Resistance 2 The review is investigating the link between chocolate (incl 1 Diabetes 1 Striae Gravidarum|Pregnancy 1 Aging|Inflammation|Cardiovascular Diseases 1 Hypertension 1 Participants with a mean age ≥18 y. Healthy or high-risk car 1 Collagen Synthesis 1 Aging|Cognitive Change 1
📋 Sample Trials
NCT03815162
Cocoa Flavanol Supplementation in Raynaud's Phenomenon
Completed
NCT00825695
Flavanol-Rich Cocoa and Cerebral Blood Flow
Completed
NCT04444388
Effect of Cocoa Supplementation in Training Athletes Microbiota and Metabolome
Completed
📊 Sample Meta-Analyses
CRD42021268620
Comparative effects of nutraceuticals on body weight and waist circumference: a protocol for a network meta-analysis of randomised clinical trials
Effect of nutraceuticals on body weight and waist circumference in adults.
CRD42018086808
The health effects of chocolate consumption: a systematic review of randomized controlled trial
Chocolate and cocoa products are being consumed globally, mainly for pleasure. C
CRD42020166426
Chronic and acute effects of cocoa products intake on arterial stiffness and platelet count and function: A systematic review and dose-response meta-analysis of randomized clinical trials.
Cardiovascular disease, Arterial stiffness, Platelet function, Cardiovascular pr
📚 Sample References
PMID 30207204
Cocoa beans improve mitochondrial biogenesis via PPARγ/PGC1α dependent signalling pathway in MPP+ intoxicated human neuroblastoma cells (SH-SY5Y)
Nutr Neurosci · 2020
🌿 All Herb data fields for Cocoa
🌿 Names
Pinyin Name
Ke Ke
中文名 (Chinese)
可可
Latin Name
Theobroma Cacao
English Name
Cocoa
☯ TCM Properties
Part Used
Seed
🩺 Clinical Profile
Function (功能)
To warm yang, disinhibit urine, raise spirit.
🔗 External References
HERB DB
HERB003106 ↗
TCMID
7698
🔍 Raw view — every non-empty column on this row (21 fields)
name
Cocoa
chinese name
可可
pinyin name
Ke Ke
latin name
Theobroma Cacao
english name
Cocoa
use part
Seed
tcmid id
7698
herb id str
HERB003106
function text
To warm yang, disinhibit urine, raise spirit.

🏥 Linked Health Topics

5 · studied for these conditions (text bridge)
Cardiovascular Diseases
group
Diabetes
syndrome
Diabetic Neuropathies
group
Insulin Resistance
phenotype
Primary Raynaud Phenomenon
syndrome

📋 Clinical Trials

12 · subject of clinical study
NCT03815162 Cocoa Flavanol Supplementation in Raynaud's Phenomenon
→ Primary Raynaud Phenomenon
NCT00825695 Flavanol-Rich Cocoa and Cerebral Blood Flow
→ Hypertension|Diabetes
NCT04444388 Effect of Cocoa Supplementation in Training Athletes Microbiota and Metabolome
→ Healthy Athletes
NCT04301583 Procyanidin B2 Enriched Cocoa Effects on Mitochondrial Biogenesis
→ Athletes
NCT01064583 Cocoa Flavanols and Painfree Walking Distance
→ Peripheral Artery Disease|Diabetes Mellitus
NCT01130727 The Effect of Green Tea or Cocoa Extracts in Endothelial Dysfunction in Patients
→ Diabetes Mellitus|Diabetic Nephropathy|Arterial Hy
NCT01651793 Effect of Phytochemicals From Theobroma Cacao on Mental Energy
→ Mental Fatigue
NCT01507259 Chocolate's Effect on the Cerebral Vasculature
→ Cerebral Vasculature
NCT02876887 Cocoa to Improve Walking Performance in Peripheral Artery Disease
→ Peripheral Artery Disease
NCT04554901 The Effect of Cocoa on Platelet Function Profiles in Patients
→ Platelet Dysfunction
NCT03897114 Cocoa Intake for Health Promotion in Athletes
→ Healthy Subjects
NCT04028128 High Flavonols Cocoa Intake for the Improvement of Body Fat Composition in Athle
→ Healthy Subjects

📊 Meta-Analyses

12 · systematic review
CRD42021268620 Comparative effects of nutraceuticals on body weight and waist circumference: a
→ Effect of nutraceuticals on body weight and waist
CRD42018086808 The health effects of chocolate consumption: a systematic review of randomized c
→ Chocolate and cocoa products are being consumed gl
CRD42020166426 Chronic and acute effects of cocoa products intake on arterial stiffness and pla
→ Cardiovascular disease, Arterial stiffness, Platel
CRD42020183193 Effectiveness of Cocoa on Dental Caries: A Systematic Review
→ Dental caries are the most worldwide prevalent ora
CRD42021224931 Potential effects of chocolates or cocoa consumption on serum lipids in ‎patient
→ Changes in blood lipid will be assessed in respons
CRD42021236478 The effects of cocoa products on cardiovascular health in patients with diabetes
→ Type 2 diabetes mellitus (T2DM) is a metabolic dis
CRD42021259878 Effects of long-term cocoa consumption on cardiovascular health outcomes in olde
→ Cocoa/chocolate consumption in older adults aged 6
CRD42021274661 Cocoa supplementation associated to exercise and its effects on oxidative stress
→ Cocoa supplementation associated to physical exerc
CRD42021274865 Cocoa supplementation associated to exercise and its effects on cardiovascular s
→ Cocoa supplementation associated to physical exerc
CRD42022287715 Effect of Cocoa Supplementation on Endurance Performance Outcomes: A Systematic
→ This systematic review will look into the existing
CRD42022323404 Effects of cocoa-based interventions on cerebral blood flow and cognitive functi
→ The review is investigating the link between choco
CRD42022355708 Comparative effects of different types of cocoa and chocolate products on interm
→ Participants with a mean age ≥18 y. Healthy or hig

📚 PubMed References

1 · cited research
PMID 30207204 Cocoa beans improve mitochondrial biogenesis via PPARγ/PGC1α dependent signallin
Nutr Neurosci
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables