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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Lactose

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Lactose

Lactose Intolerance 2 Lactose intolerance in adults and children aged 10 years or 1 Bacterial Vaginoses 1 Diarrhea is defined by WHO as having three or more loose or 1 Acute Diarrhea 1 Coronavirus disease 2019 (COVID-19) is a human infectious di 1 Celiac disease is a autoimmune disorder in which peaple have 1 45 million children younger than five years suffered from wa 1 Non-celiac Wheat Sensitivity 1 Neonatal Abstinence Syndrome 1 Populations of interest include healthy individuals and peop 1 Lactose Intolerance|Ulcerative Colitis 1

📋 Sample Trials

NCT01269892

Early Administration of Lactose-free Milk in Children Presenting With Acute Diarrhea

Completed · Phase 2

NCT00403923

Amount of Lactose Causing Symptoms in People With Lactose Intolerance and Ulcerative Colitis

Completed

NCT00599859

Effects of Lactose on Fecal Microflora

Completed

📊 Sample Meta-Analyses

CRD42017064802

Country, regional and global estimates for lactose malabsorption in adults: a systematic review and meta-analysis

Lactose malabsorption in adults

CRD42022373626

Systematic review and meta-analysis of lactose intolerance; the global, regional, and national prevalence in adults and children aged 10 years or older.

Lactose intolerance in adults and children aged 10 years or older.

CRD42013003896

Effects of lactose-free formula on the treatment of acute diarrhea in children:a meta-analysis

Diarrhea is defined by WHO as having three or more loose or liquid stools per da

📚 Sample References

PMID 31711923

Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa

Gastroenterology · 2020

PMID 32253406

The impact of oligosaccharide content, glycosidic linkages and lactose content of galacto-oligosaccharides (GOS) on the expression of mucus-related genes in goblet cells

Food Funct · 2020

⚗️ All Ingredient data fields for Lactose

⚗️ Identity

Name

Lactose

Aliases / Synonyms

(+)-Lactose; .beta.-Lactose; 4-(beta-D-Galactosido)-D-glucose; 4-O-beta-D-Galactopyranosyl-beta-D-glucopyranose; 4-O-beta-D-Galactopyranosyl-D-glucose; beta-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-; beta-D-Lactose; beta-Lactose; D-(+)-Lactose; D-Glucose, 4-O-beta-D-galactopyranosyl

🧪 Chemistry

Molecular Weight

342.2970

LogP

-5.3972

Drug-likeness

0.243

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)O)CO)O)O)O)O

Isomeric SMILES

C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O)CO)O)O)O)O

InChIKey

GUBGYTABKSRVRQ-DCSYEGIMSA-N

InChI

InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11-,12+/m1/s1

🔗 External References

HERB DB

HBIN032538 ↗

PubChem CID

6134 ↗

NPASS

NPC58629

SymMap

16236

TCMID

12435

🔍 Raw view — every non-empty column on this row (29 fields)

name

Lactose

common names

herb ingredient id

HBIN032538

canonical smiles

C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)O)CO)O)O)O)O

isomeric smiles

C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O)CO)O)O)O)O

inchi

InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11-,12+/m1/s1

inchikey

GUBGYTABKSRVRQ-DCSYEGIMSA-N

mol wt

342.2970

num h acceptors

num h donors

mol logp

-5.3972

num rotatable bonds

drug likeness

0.243

symmap mol id

16236

tcmid ingredient id

12435

pubchem cid

6134

npass id

NPC58629

🏥 Linked Health Topics

4 · diseases via target pathways

Irritable Bowel Syndrome

syndrome

Lactose Intolerance

syndrome

Neonatal Abstinence Syndrome

syndrome

Acute Diarrhea

syndrome

📋 Clinical Trials

9 · subject of clinical study

NCT01269892 Early Administration of Lactose-free Milk in Children Presenting With Acute Diar

→ Acute Diarrhea

NCT00403923 Amount of Lactose Causing Symptoms in People With Lactose Intolerance and Ulcera

→ Lactose Intolerance|Ulcerative Colitis

NCT00599859 Effects of Lactose on Fecal Microflora

→ Lactose Intolerance

NCT03008252 Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivi

→ Non-celiac Wheat Sensitivity

NCT03878511 Therapeutic Lactose to Support Vaginal Microbiota

→ Bacterial Vaginoses

NCT04924530 Effect of Lactose on Blood Lipids

→ Cardiovascular Risk Factor|Lipaemia|Metabolic Dise

NCT02636413 Evaluation of LacTEST for the Diagnosis of Hypolactasia in Adults and Elderly Pa

→ Lactose Intolerance

NCT03549936 Role of Low Lactose Infant Formula In The Management of Neonatal Abstinence Synd

→ Neonatal Abstinence Syndrome

NCT05001997 Effects of Lactose-free Dairy Products on Athletes With Irritable Bowel Syndrome

→ Irritable Bowel Syndrome

📊 Meta-Analyses

10 · systematic review

CRD42017064802 Country, regional and global estimates for lactose malabsorption in adults: a sy

→ Lactose malabsorption in adults

CRD42022373626 Systematic review and meta-analysis of lactose intolerance; the global, regional

→ Lactose intolerance in adults and children aged 10

CRD42013003896 Effects of lactose-free formula on the treatment of acute diarrhea in children:

→ Diarrhea is defined by WHO as having three or more

CRD42015027202 Prevalence, cause and diagnosis of lactose intolerance in children aged 1-5 year

CRD42017069928 The influence of celiac disease and lactose intolerance on oral conditions: a sy

→ Celiac disease is a autoimmune disorder in which p

CRD42019135388 Health effects of lactose-free milk and dairy products – a systematic review of

→ Populations of interest include healthy individual

CRD42020178960 Lactose dehydrogenase in patients with severe COVID-19: a meta-analysis of retro

→ Coronavirus disease 2019 (COVID-19) is a human inf

CRD42021289220 Hydrolysed- and lactose-free feeds compared to standard F75 and F100 for the tre

→ 45 million children younger than five years suffer

CRD42022295691 Probiotics and prebiotics in the symptomatic treatment of lactose intolerance in

→ Lactose intolerance is a condition when occurred a

CRD42023459005 Role of dietary supplements in type 2 diabetes mellitus with coronary heart dise

→ Outcomes associated with populations in type 2 dia

📚 PubMed References

2 · cited research

PMID 31711923 Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Gl

Gastroenterology

PMID 32253406 The impact of oligosaccharide content, glycosidic linkages and lactose content o

Food Funct

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables